An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway

Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-γ in primary macrophages requires endogenous 25-hydroxycholesterol synthesis

(2015) Hongjin Lu et al.   STEROIDS

Long-term safety and efficacy of microRNA-targeted therapy in chronic hepatitis C patients

(2014) Meike H. van der Ree et al.   ANTIVIRAL RESEARCH

MicroRNA miR-21 Attenuates Human Cytomegalovirus Replication in Neural Cells by Targeting Cdc25a

(2014) Ya-Ru Fu et al.   JOURNAL OF VIROLOGY

Noncoding RNA and its associated proteins as regulatory elements of the immune system

(2014) Martin Turner et al.   NATURE IMMUNOLOGY

25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon

(2014) A. Reboldi et al.   SCIENCE

Interferon-stimulated genes: roles in viral pathogenesis

(2014) John W Schoggins   Current Opinion in Virology

A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway

(2013) Alexander Mazein et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of mevalonate metabolism in cancer and immune cells

(2013) Martin Thurnher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipids in Innate Antiviral Defense

(2013) John W. Schoggins et al.   Cell Host & Microbe

The microRNA-342-5p Fosters Inflammatory Macrophage Activation Through an Akt1- and microRNA-155 –Dependent Pathway During Atherosclerosis

(2013) Yuanyuan Wei et al.   CIRCULATION

Control of Cholesterol Metabolism and Plasma High-Density Lipoprotein Levels by microRNA-144

(2013) Cristina M. Ramírez et al.   CIRCULATION RESEARCH

RNAi and antiviral defense in Drosophila: Setting up a systemic immune response

(2013) Margot Karlikow et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

25-Hydroxycholesterol Activates the Integrated Stress Response to Reprogram Transcription and Translation in Macrophages

(2013) Norihito Shibata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake

(2013) Muhua Yang et al.   JOURNAL OF LIPID RESEARCH

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

(2013) Yoko Kidani et al.   NATURE IMMUNOLOGY

Sterols and oxysterols in immune cell function

(2013) Nathanael J Spann et al.   NATURE IMMUNOLOGY

MicroRNA-185 and 342 Inhibit Tumorigenicity and Induce Apoptosis through Blockade of the SREBP Metabolic Pathway in Prostate Cancer Cells

(2013) Xiangyan Li et al.   PLoS One

MiR-155 Has a Protective Role in the Development of Non-Alcoholic Hepatosteatosis in Mice

(2013) Ashley M. Miller et al.   PLoS One

RNA Interference Functions as an Antiviral Immunity Mechanism in Mammals

(2013) Y. Li et al.   SCIENCE

Antiviral RNA Interference in Mammalian Cells

(2013) P. V. Maillard et al.   SCIENCE

Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier

(2013) Kim A Lennox et al.   Molecular Therapy-Nucleic Acids

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

(2012) Nathanael J. Spann et al.   CELL

Analytical strategies for characterization of oxysterol lipidomes: Liver X receptor ligands in plasma

(2012) William J. Griffiths et al.   FREE RADICAL BIOLOGY AND MEDICINE

Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol

(2012) Su-Yang Liu et al.   IMMUNITY

The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response

(2012) Mathieu Blanc et al.   IMMUNITY

Lipid Metabolite Profiling Identifies Desmosterol Metabolism as a New Antiviral Target for Hepatitis C Virus

(2012) Mary A. Rodgers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MicroRNA Targeting of Neurotropic Flavivirus: Effective Control of Virus Escape and Reversion to Neurovirulent Phenotype

(2012) B. L. Heiss et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Infection Induces Adipocyte-Like Lipogenesis through Activation of Sterol Regulatory Element Binding Protein 1

(2012) Y. Yu et al.   JOURNAL OF VIROLOGY

MicroRNAs 125a and 455 Repress Lipoprotein-Supported Steroidogenesis by Targeting Scavenger Receptor Class B Type I in Steroidogenic Cells

(2012) Z. Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

BioGPS and MyGene.info: organizing online, gene-centric information

(2012) Chunlei Wu et al.   NUCLEIC ACIDS RESEARCH

Dynamic regulation of microRNA expression following Interferon-γ-induced gene transcription

(2012) Susanne Reinsbach et al.   RNA Biology

MiR-342-5p suppresses coxsackievirus B3 biosynthesis by targeting the 2C-coding region

(2011) Linlin Wang et al.   ANTIVIRAL RESEARCH

Genome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Role in Autophagy

(2011) Young-Kyo Seo et al.   Cell Metabolism

Linking Lipid Metabolism to the Innate Immune Response in Macrophages through Sterol Regulatory Element Binding Protein-1a

(2011) Seung-Soon Im et al.   Cell Metabolism

miRWalk – Database: Prediction of possible miRNA binding sites by “walking” the genes of three genomes

(2011) Harsh Dweep et al.   JOURNAL OF BIOMEDICAL INFORMATICS

The perplexing case of the geranylgeranyl transferase–deficient mouse

(2011) Mark R. Philips   JOURNAL OF CLINICAL INVESTIGATION

Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice

(2011) Omar M. Khan et al.   JOURNAL OF CLINICAL INVESTIGATION

Protection against TNFα-dependent liver toxicity by intraperitoneal liposome delivered DsiRNA targeting TNFα in vivo

(2011) Patric Lundberg et al.   JOURNAL OF CONTROLLED RELEASE

Reversible Inhibition of Murine Cytomegalovirus Replication by Gamma Interferon (IFN- ) in Primary Macrophages Involves a Primed Type I IFN-Signaling Subnetwork for Full Establishment of an Immediate-Early Antiviral State

(2011) K. A. Kropp et al.   JOURNAL OF VIROLOGY

Expression and Localization of microRNAs in Perinatal Rat Pancreas: Role of miR-21 in Regulation of Cholesterol Metabolism

(2011) Louise Larsen et al.   PLoS One

Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis

(2011) Mathieu Blanc et al.   PLOS BIOLOGY

Inducible microRNA-155 Feedback Promotes Type I IFN Signaling in Antiviral Innate Immunity by Targeting Suppressor of Cytokine Signaling 1

(2010) P. Wang et al.   JOURNAL OF IMMUNOLOGY

The Rab11 Pathway Is Required for Influenza A Virus Budding and Filament Formation

(2010) E. A. Bruce et al.   JOURNAL OF VIROLOGY

Combined agonist-antagonist genome-wide functional screening identifies broadly active antiviral microRNAs

(2010) D. Santhakumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Down-Regulation of a Host MicroRNA by a Herpesvirus saimiri Noncoding RNA

(2010) D. Cazalla et al.   SCIENCE

MiR-33 Contributes to the Regulation of Cholesterol Homeostasis

(2010) K. J. Rayner et al.   SCIENCE

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

A new molecular network comprising PU.1, interferon regulatory factor proteins and miR-342 stimulates ATRA-mediated granulocytic differentiation of acute promyelocytic leukemia cells

(2009) M L De Marchis et al.   LEUKEMIA

High-resolution gene expression profiling for simultaneous kinetic parameter analysis of RNA synthesis and decay

(2008) L. Dolken et al.   RNA