The transcription factor HIF2α partakes in the differentiation block of acute myeloid leukemia

Dual intron-targeted CRISPR-Cas9-mediated disruption of the AML RUNX1-RUNX1T1 fusion gene effectively inhibits proliferation and decreases tumor volume in vitro and in vivo

(2023) Signe Neldeborg et al.   LEUKEMIA

Integrated Multiomic Profiling Identifies the Epigenetic Regulator PRC2 as a Therapeutic Target to Counteract Leukemia Immune Escape and Relapse

(2022) Valentina Gambacorta et al.   Cancer Discovery

Retinoids in haematology : a timely revival?

(2021) Hugues de The et al.   BLOOD

MK-6482 as a potential treatment for von Hippel-Lindau disease-associated clear cell renal cell carcinoma

(2021) Elshad Hasanov et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance

(2021) Xiaopeng Li et al.   Cell Reports

BCL11A promotes myeloid leukemogenesis by repressing PU.1 target genes

(2021) Yoshitaka Sunami et al.   Blood Advances

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation

(2019) Cristina Toffalori et al.   NATURE MEDICINE

Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy

(2019) Vera Mugoni et al.   CELL RESEARCH

Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis

(2019) Cates Mallaney et al.   LEUKEMIA

Rational targeting of cooperating layers of the epigenome yields enhanced therapeutic efficacy against AML

(2019) Cihangir Duy et al.   Cancer Discovery

The ENCODE Blacklist: Identification of Problematic Regions of the Genome

(2019) Haley M. Amemiya et al.   Scientific Reports

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia

(2019) Mark D. McKenzie et al.   Cell Stem Cell

Role of GFI1 in Epigenetic Regulation of MDS and AML Pathogenesis: Mechanisms and Therapeutic Implications

(2019) Tarik Möröy et al.   Frontiers in Oncology

HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor in Clear Cell Renal Cell Carcinoma Patients

(2019) Kevin D Courtney et al.   CLINICAL CANCER RESEARCH

Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma

(2018) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a

(2018) Kun-Yong Kim et al.   Nature Communications

Hypoxia-inducible factor 2α: a novel target in gliomas

(2018) Jaclyn J Renfrow et al.   Future Medicinal Chemistry

HIF-α factors as potential therapeutic targets in leukemia

(2018) Daniela Magliulo et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Functional genomic landscape of acute myeloid leukaemia

(2018) Jeffrey W. Tyner et al.   NATURE

Hif-1α Deletion May Lead to Adverse Treatment Effect in a Mouse Model of MLL-AF9-Driven AML

(2018) Talia Velasco-Hernandez et al.   Stem Cell Reports

Reprogramming acute myeloid leukemia into sensitivity for retinoic-acid-driven differentiation

(2017) Noortje van Gils et al.   EXPERIMENTAL HEMATOLOGY

TRIM28 and Interacting KRAB-ZNFs Control Self-Renewal of Human Pluripotent Stem Cells through Epigenetic Repression of Pro-differentiation Genes

(2017) Urszula Oleksiewicz et al.   Stem Cell Reports

All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD+ leukemia stem cells in vitro and in vivo

(2016) H. S. Ma et al.   BLOOD

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

(2016) Hartmut Döhner et al.   BLOOD

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

(2016) Eli M. Wallace et al.   CANCER RESEARCH

Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution

(2016) M Ryan Corces et al.   NATURE GENETICS

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes

(2016) Jingyao Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia inducible factor-1α regulates a pro-invasive phenotype in acute monocytic leukemia

(2016) Jessica Migliavacca et al.   Oncotarget

Primary acute myeloid leukemia cells with overexpression of EVI-1 are sensitive to all-trans retinoic acid

(2015) H. J. M. P. Verhagen et al.   BLOOD

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells

(2015) H. El Hajj et al.   BLOOD

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance

(2015) Milica Vukovic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML

(2015) C E Forristal et al.   LEUKEMIA

AML1/ETO cooperates with HIF1α to promote leukemogenesis through DNMT3a transactivation

(2015) X N Gao et al.   LEUKEMIA

Orchestrating high-throughput genomic analysis with Bioconductor

(2015) Wolfgang Huber et al.   NATURE METHODS

BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis

(2015) Frederik Otzen Bagger et al.   NUCLEIC ACIDS RESEARCH

CDK6 as a key regulator of hematopoietic and leukemic stem cell activation

(2014) Ruth Scheicher et al.   BLOOD

HIF-1  can act as a tumor suppressor gene in murine acute myeloid leukemia

(2014) T. Velasco-Hernandez et al.   BLOOD

HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse

(2014) Nadia Coltella et al.   EMBO Molecular Medicine

deepTools: a flexible platform for exploring deep-sequencing data

(2014) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

Convergence of Hypoxia and TGFβ Pathways on Cell Cycle Regulation in Human Hematopoietic Stem/Progenitor Cells

(2014) Albertus T. J. Wierenga et al.   PLoS One

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress

(2013) Kevin Rouault-Pierre et al.   Cell Stem Cell

Transcriptional regulation by hypoxia inducible factors

(2013) Veronica L. Dengler et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia

(2013) Francesco Lo-Coco et al.   NEW ENGLAND JOURNAL OF MEDICINE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells

(2012) F. Kocabas et al.   BLOOD

A Long ncRNA Links Copy Number Variation to a Polycomb/Trithorax Epigenetic Switch in FSHD Muscular Dystrophy

(2012) Daphne S. Cabianca et al.   CELL

HIF-1α protein is upregulated in HIF-2α depleted cells via enhanced translation

(2012) Kathrin Schulz et al.   FEBS LETTERS

GENCODE: The reference human genome annotation for The ENCODE Project

(2012) J. Harrow et al.   GENOME RESEARCH

ATRA and the specific RARα agonist, NRX195183, have opposing effects on the clonogenicity of pre-leukemic murine AML1-ETO bone marrow cells

(2012) L C Y Chee et al.   LEUKEMIA

Elevated HIF-1α expression of acute myelogenous leukemia stem cells in the endosteal hypoxic zone may be a cause of minimal residual disease in bone marrow after chemotherapy

(2012) T. Matsunaga et al.   LEUKEMIA RESEARCH

HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5

(2012) Ainara Elorza et al.   MOLECULAR CELL

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies

(2011) Yin Wang et al.   Cell Stem Cell

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Tumor Regression and Curability of Preclinical Neuroblastoma Models by PEGylated SN38 (EZN-2208), a Novel Topoisomerase I Inhibitor

(2010) F. Pastorino et al.   CLINICAL CANCER RESEARCH

Runx2 induces acute myeloid leukemia in cooperation with Cbf -SMMHC in mice

(2009) Y.-H. Kuo et al.   BLOOD

Regulated and Multiple miRNA and siRNA Delivery Into Primary Cells by a Lentiviral Platform

(2009) Mario Amendola et al.   MOLECULAR THERAPY

PML targeting eradicates quiescent leukaemia-initiating cells

(2008) Keisuke Ito et al.   NATURE