Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance

Effective targeting of primitive AML CD34+cells by the second-generation proteasome inhibitor carfilzomib

(2015) Lieke H. van der Helm et al.   BRITISH JOURNAL OF HAEMATOLOGY

The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential

(2015) Stephen H.K. Wong et al.   CANCER CELL

Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia

(2015) Hyog Young Kwon et al.   Cell Stem Cell

The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

(2015) Anna K Andersson et al.   NATURE GENETICS

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias

(2015) Vincent-Philippe Lavallée et al.   NATURE GENETICS

Targeting HIF function: the debate continues

(2014) P. Vyas   BLOOD

HIF-1  can act as a tumor suppressor gene in murine acute myeloid leukemia

(2014) T. Velasco-Hernandez et al.   BLOOD

18F-FAZA PET Imaging Response Tracks the Reoxygenation of Tumors in Mice upon Treatment with the Mitochondrial Complex I Inhibitor BAY 87-2243

(2014) E. Chang et al.   CLINICAL CANCER RESEARCH

The methyltransferase G9a regulates HoxA9-dependent transcription in AML

(2014) B. Lehnertz et al.   GENES & DEVELOPMENT

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

BAY 87–2243, a novel inhibitor of hypoxia-induced gene activation, improves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts

(2014) Linda Helbig et al.   Radiation Oncology

Concise Review: Genetic Dissection of Hypoxia Signaling Pathways in Normal and Leukemic Stem Cells

(2014) Deniz Gezer et al.   STEM CELLS

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Eradicating acute myeloid leukemia in a MllPTD/wt:Flt3ITD/wt murine model: a path to novel therapeutic approaches for human disease

(2013) K. M. Bernot et al.   BLOOD

Hif-2  is not essential for cell-autonomous hematopoietic stem cell maintenance

(2013) A. V. Guitart et al.   BLOOD

HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress

(2013) Kevin Rouault-Pierre et al.   Cell Stem Cell

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I

(2013) Peter Ellinghaus et al.   Cancer Medicine

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies

(2011) Yin Wang et al.   Cell Stem Cell

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells

(2009) Tim C.P. Somervaille et al.   Cell Stem Cell

Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells

(2009) Kamil R. Kranc et al.   Cell Stem Cell

Proteasome Enzymatic Activities in Plasma as Risk Stratification of Patients with Acute Myeloid Leukemia and Advanced-Stage Myelodysplastic Syndrome

(2009) W. Ma et al.   CLINICAL CANCER RESEARCH

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

(2009) David R. Mole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

A role for MEIS1 in MLL-fusion gene leukemia

(2008) A. R. Kumar et al.   BLOOD

Malignant Transformation Initiated by Mll-AF9: Gene Dosage and Critical Target Cells

(2008) Weili Chen et al.   CANCER CELL

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

(2008) Timothy J. Ley et al.   NATURE