- Home
- Publications
- Publication Search
- Publication Details
Title
HIF-α factors as potential therapeutic targets in leukemia
Authors
Keywords
-
Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 22, Issue 11, Pages 917-928
Publisher
Informa UK Limited
Online
2018-10-20
DOI
10.1080/14728222.2018.1538357
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Chronic myeloid leukemia: 2018 update on diagnosis, therapy and monitoring
- (2018) Elias Jabbour et al. AMERICAN JOURNAL OF HEMATOLOGY
- HIF2 Inhibitor Joins the Kidney Cancer Armamentarium
- (2018) William G. Kaelin JOURNAL OF CLINICAL ONCOLOGY
- Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma
- (2018) Kevin D. Courtney et al. JOURNAL OF CLINICAL ONCOLOGY
- New horizons in hypoxia signaling pathways
- (2017) Christopher W. Pugh et al. EXPERIMENTAL CELL RESEARCH
- mRNA overexpression of the hypoxia inducible factor 1 alpha subunit gene (HIF1A): An independent predictor of poor overall survival in chronic lymphocytic leukemia
- (2017) Christos K. Kontos et al. LEUKEMIA RESEARCH
- Integration of hypoxic HIF-α signaling in blood cancers
- (2017) L Schito et al. ONCOGENE
- Acute lymphoblastic leukemia: a comprehensive review and 2017 update
- (2017) T Terwilliger et al. Blood Cancer Journal
- Chronic lymphocytic leukaemia
- (2017) Thomas J. Kipps et al. Nature Reviews Disease Primers
- Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer
- (2017) Luisa Iommarini et al. Frontiers in Oncology
- Hypoxia-inducible factor 3 biology: complexities and emerging themes
- (2016) Cunming Duan AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Adult hematopoietic stem cells lacking Hif-1 self-renew normally
- (2016) M. Vukovic et al. BLOOD
- HIF-1 regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment
- (2016) R. Valsecchi et al. BLOOD
- Pioglitazone together with imatinib in chronic myeloid leukemia: A proof of concept study
- (2016) Philippe Rousselot et al. CANCER
- A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma
- (2016) Eli M. Wallace et al. CANCER RESEARCH
- Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact
- (2016) Kevin Rouault-Pierre et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Targeting renal cell carcinoma with a HIF-2 antagonist
- (2016) Wenfang Chen et al. NATURE
- On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
- (2016) Hyejin Cho et al. NATURE
- Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
- (2016) Caroline Wigerup et al. PHARMACOLOGY & THERAPEUTICS
- ‘Acute myeloid leukemia: a comprehensive review and 2016 update’
- (2016) I De Kouchkovsky et al. Blood Cancer Journal
- Hypoxia inducible factor-1α regulates a pro-invasive phenotype in acute monocytic leukemia
- (2016) Jessica Migliavacca et al. Oncotarget
- Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases
- (2016) Salminen Antero et al. Aging and Disease
- Hypoxia and Hypoxia-Inducible Factors in Leukemias
- (2016) Margaux Deynoux et al. Frontiers in Oncology
- Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling
- (2015) Vincenzo Giambra et al. BLOOD
- Synergistic Leukemia Eradication by Combined Treatment with Retinoic Acid and HIF Inhibition by EZN-2208 (PEG-SN38) in Preclinical Models of PML-RAR and PLZF-RAR -Driven Leukemia
- (2015) N. Coltella et al. CLINICAL CANCER RESEARCH
- Concise Review: The Role of Oxygen in Hematopoietic Stem Cell Physiology
- (2015) Mojca Jež et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance
- (2015) Milica Vukovic et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML
- (2015) C E Forristal et al. LEUKEMIA
- AML1/ETO cooperates with HIF1α to promote leukemogenesis through DNMT3a transactivation
- (2015) X N Gao et al. LEUKEMIA
- Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists
- (2015) Stéphane Prost et al. NATURE
- Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells
- (2015) Micol Rigoni et al. Oncotarget
- HIF-1 can act as a tumor suppressor gene in murine acute myeloid leukemia
- (2014) T. Velasco-Hernandez et al. BLOOD
- Direct measurement of local oxygen concentration in the bone marrow of live animals
- (2014) Joel A. Spencer et al. NATURE
- Phase 1 evaluation of EZN-2208, a polyethylene glycol conjugate of SN38, in children adolescents and young adults with relapsed or refractory solid tumors
- (2014) Robin E. Norris et al. PEDIATRIC BLOOD & CANCER
- Bone Marrow Endosteal Mesenchymal Progenitors Depend on HIF Factors for Maintenance and Regulation of Hematopoiesis
- (2014) Jlenia Guarnerio et al. Stem Cell Reports
- Hif-2 is not essential for cell-autonomous hematopoietic stem cell maintenance
- (2013) A. V. Guitart et al. BLOOD
- Multimodal imaging reveals structural and functional heterogeneity in different bone marrow compartments: functional implications on hematopoietic stem cells
- (2013) F. Lassailly et al. BLOOD
- HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress
- (2013) R. P. Singh et al. BLOOD
- HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress
- (2013) Kevin Rouault-Pierre et al. Cell Stem Cell
- Transcriptional regulation by hypoxia inducible factors
- (2013) Veronica L. Dengler et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
- (2013) Gregg L. Semenza JOURNAL OF CLINICAL INVESTIGATION
- Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells
- (2013) Jie Zou et al. Journal of Hematology & Oncology
- Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor
- (2013) Jamie L. Rogers et al. JOURNAL OF MEDICINAL CHEMISTRY
- Allosteric inhibition of hypoxia inducible factor-2 with small molecules
- (2013) Thomas H Scheuermann et al. Nature Chemical Biology
- Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells
- (2012) F. Kocabas et al. BLOOD
- HIF1 is required for survival maintenance of chronic myeloid leukemia stem cells
- (2012) H. Zhang et al. BLOOD
- Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment
- (2012) Olga Frolova et al. CANCER BIOLOGY & THERAPY
- HIF-1α protein is upregulated in HIF-2α depleted cells via enhanced translation
- (2012) Kathrin Schulz et al. FEBS LETTERS
- Elevated HIF-1α expression of acute myelogenous leukemia stem cells in the endosteal hypoxic zone may be a cause of minimal residual disease in bone marrow after chemotherapy
- (2012) T. Matsunaga et al. LEUKEMIA RESEARCH
- IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
- (2012) Masato Sasaki et al. NATURE
- The VHL/HIF axis in clear cell renal carcinoma
- (2012) Chuan Shen et al. SEMINARS IN CANCER BIOLOGY
- Passing the baton: the HIF switch
- (2012) Mei Yee Koh et al. TRENDS IN BIOCHEMICAL SCIENCES
- High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
- (2011) J. Schodel et al. BLOOD
- Identification of HIF2 as an important STAT5 target gene in human hematopoietic stem cells
- (2011) S. Fatrai et al. BLOOD
- Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies
- (2011) Yin Wang et al. Cell Stem Cell
- The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche
- (2010) Tugba Simsek et al. Cell Stem Cell
- Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells
- (2010) Keiyo Takubo et al. Cell Stem Cell
- Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming
- (2010) F Zhao et al. ONCOGENE
- Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in Metazoans
- (2010) Cormac T. Taylor et al. PHYSIOLOGY
- Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells
- (2009) A. K. Ghosh et al. BLOOD
- Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
- (2009) David R. Mole et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Oxygen homeostasis
- (2009) Gregg L. Semenza Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
- (2008) William G. Kaelin et al. MOLECULAR CELL
- Digoxin and other cardiac glycosides inhibit HIF-1 synthesis and block tumor growth
- (2008) H. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started