MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression

Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway

(2022) Jiaqi Jin et al.   NUCLEIC ACIDS RESEARCH

O-GlcNAcylation: An Emerging Protein Modification Regulating the Hippo Pathway

(2022) Eunah Kim et al.   Cancers

Regulation of MST complexes and activity via SARAH domain modifications

(2021) Sofiia Karchugina et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis

(2021) Shasha Yin et al.   Nature Communications

Biological Significance of YAP/TAZ in Pancreatic Ductal Adenocarcinoma

(2021) Hiromitsu Hayashi et al.   Frontiers in Oncology

Cellular pathways influenced by protein arginine methylation: Implications for cancer

(2021) Jian Xu et al.   MOLECULAR CELL

PRMT5: An Emerging Target for Pancreatic Adenocarcinoma

(2021) Michael K. C. Lee et al.   Cancers

YAP/TAZ: Drivers of Tumor Growth, Metastasis, and Resistance to Therapy

(2020) Barry J. Thompson   BIOESSAYS

Biophysical characterization of SARAH domain–mediated multimerization of Hippo pathway complexes in Drosophila

(2020) Leah Cairns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

537MO First-in-human study of JNJ-64619178, a protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced cancers

(2020) M. Vieito Villar et al.   ANNALS OF ONCOLOGY

Increasing kinase domain proximity promotes MST2 autophosphorylation during Hippo signaling

(2020) Thao Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells

(2020) Xiaolong Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo Signaling Pathway in Pancreatic Cancer

(2019) DANIEL ANSARI et al.   ANTICANCER RESEARCH

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss

(2019) Andrew Fedoriw et al.   CANCER CELL

The Hippo Signaling Pathway in Development and Disease

(2019) Yonggang Zheng et al.   DEVELOPMENTAL CELL

Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

(2019) Shatha AbuHammad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

438OMETEOR-1: A phase I study of GSK3326595, a first-in-class protein arginine methyltransferase 5 (PRMT5) inhibitor, in advanced solid tumours

(2019) L L Siu et al.   ANNALS OF ONCOLOGY

A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas

(2019) Shigekazu Murakami et al.   DEVELOPMENTAL CELL

PRMT5 promotes epithelial‐mesenchymal transition via EGFR‐β‐catenin axis in pancreatic cancer cells

(2019) Lu Ge et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis

(2018) Lan Fang et al.   CANCER CELL

Therapeutic developments in pancreatic cancer: current and future perspectives

(2018) John P. Neoptolemos et al.   Nature Reviews Gastroenterology & Hepatology

Activation mechanisms of the Hippo kinase signaling cascade

(2018) Sung Jun Bae et al.   BIOSCIENCE REPORTS

Protein Language: Post-Translational Modifications Talking to Each Other

(2018) Lam Dai Vu et al.   TRENDS IN PLANT SCIENCE

Arginine Methylation: The Coming of Age

(2017) Roméo S. Blanc et al.   MOLECULAR CELL

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK

(2017) Sung Jun Bae et al.   eLife

Arginine Methylation of SREBP1a via PRMT5 Promotes De Novo Lipogenesis and Tumor Growth

(2016) L. Liu et al.   CANCER RESEARCH

H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization

(2016) Sonali J. Rawat et al.   CURRENT BIOLOGY

Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer

(2016) Yi-Ping Wang et al.   MOLECULAR CELL

Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma

(2016) S Murakami et al.   ONCOGENE

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

(2016) Fuqin Fan et al.   Science Translational Medicine

SARAH Domain-Mediated MST2-RASSF Dimeric Interactions

(2016) Goar Sánchez-Sanz et al.   PLoS Computational Biology

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

(2015) Nicole Stopa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

(2013) Feng Yin et al.   CELL

Hippo activation through homodimerization and membrane association for growth inhibition and organ size control

(2013) Yaoting Deng et al.   DEVELOPMENTAL BIOLOGY

Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5

(2013) Lisheng Ni et al.   STRUCTURE

A Novel Acetylation Cycle of Transcription Co-activator Yes-associated Protein That Is Downstream of Hippo Pathway Is Triggered in Response toSN2 Alkylating Agents

(2012) Shoji Hata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dimerization and Cytoplasmic Localization Regulate Hippo Kinase Signaling Activity in Organ Size Control

(2012) Yunyun Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

MOBKL1A/MOBKL1B Phosphorylation by MST1 and MST2 Inhibits Cell Proliferation

(2008) Maria Praskova et al.   CURRENT BIOLOGY

A Genecentric Human Protein Atlas for Expression Profiles Based on Antibodies

(2008) Lisa Berglund et al.   MOLECULAR & CELLULAR PROTEOMICS