The Molecular Mechanisms Involved in Axonal Degeneration and Retrograde Retinal Ganglion Cell Death

NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve

(2023) James R. Tribble et al.   Acta Neuropathologica Communications

FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury

(2022) Bohm Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMNAT2 is downregulated in glaucomatous RGCs, and RGC-specific gene therapy rescues neurodegeneration and visual function

(2022) Fang Fang et al.   MOLECULAR THERAPY

SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites

(2022) Carlo Angeletti et al.   iScience

Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules

(2022) Yun Shi et al.   MOLECULAR CELL

Protective effects of NAMPT or MAPK inhibitors and NaR on Wallerian degeneration of mammalian axons

(2022) Athanasios S. Alexandris et al.   NEUROBIOLOGY OF DISEASE

Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease

(2022) Matthew Bratkowski et al.   NEURON

Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain

(2022) Hannah C. Feldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

(2021) Matthew D. Figley et al.   NEURON

Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy

(2021) Todd Bosanac et al.   BRAIN

An NAD+/NMN balancing act by SARM1 and NMNAT2 controls axonal degeneration

(2021) Thomas J. Waller et al.   NEURON

Inhibition of dual leucine zipper kinase prevents chemotherapy-induced peripheral neuropathy and cognitive impairments

(2021) Jiacheng Ma et al.   PAIN

Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed

(2021) Azadeh Izadifar et al.   NEURON

Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets

(2021) Gülgün Tezel   PROGRESS IN RETINAL AND EYE RESEARCH

The calcium-dependent protease calpain in neuronal remodeling and neurodegeneration

(2021) Elsayed Metwally et al.   TRENDS IN NEUROSCIENCES

A Novel NAD Signaling Mechanism in Axon Degeneration and its Relationship to Innate Immunity

(2021) Eleanor L. Hopkins et al.   Frontiers in Molecular Biosciences

Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection

(2021) Yo Sasaki et al.   EXPERIMENTAL NEUROLOGY

cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons

(2020) Yo Sasaki et al.   EXPERIMENTAL NEUROLOGY

The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease

(2020) Matthew D Figley et al.   CURRENT OPINION IN NEUROBIOLOGY

The role of TLR4/NF-κB signaling pathway in activated microglia of rats with chronic high intraocular pressure and vitro scratch injury-induced microglia

(2020) Hongjun Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration

(2020) Kwang Woo Ko et al.   JOURNAL OF CELL BIOLOGY

Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1

(2020) Matthew Bratkowski et al.   Cell Reports

JNK/c-Jun-driven NLRP3 inflammasome activation in microglia contributed to retinal ganglion cells degeneration induced by indirect traumatic optic neuropathy

(2020) Xiaoqi Chu et al.   EXPERIMENTAL EYE RESEARCH

Retinal ischemia triggers early microglia activation in the optic nerve followed by neurofilament degeneration

(2020) Marina Palmhof et al.   EXPERIMENTAL EYE RESEARCH

Axonal Protection by Nicotinamide Riboside via SIRT1-Autophagy Pathway in TNF-Induced Optic Nerve Degeneration

(2020) Yasushi Kitaoka et al.   MOLECULAR NEUROBIOLOGY

Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma

(2019) Pete A. Williams et al.   Molecular Neurodegeneration

Application of CNTF or FGF-2 increases the number of M2-like macrophages after optic nerve injury in adult Rana pipiens

(2019) Rosa E. Blanco et al.   PLoS One

Potential role of P2X7 receptor in neurodegenerative processes in a murine model of glaucoma

(2019) María J. Pérez de Lara et al.   BRAIN RESEARCH BULLETIN

Mechanisms of injury-induced axon degeneration

(2019) Chen Ding et al.   CURRENT OPINION IN NEUROBIOLOGY

Effect of ocular hypertension on the pattern of retinal ganglion cell subtype loss in a mouse model of early-onset glaucoma

(2019) S. Daniel et al.   EXPERIMENTAL EYE RESEARCH

Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes

(2019) Nicholas M. Tran et al.   NEURON

Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury

(2018) Kimberly A. Fernandes et al.   EXPERIMENTAL EYE RESEARCH

PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2

(2018) Muriel Desbois et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma

(2018) Alejandra Bosco et al.   MOLECULAR THERAPY

Palmitoylation enables MAPK-dependent proteostasis of axon survival factors

(2018) Daniel W. Summers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis

(2018) Diego E. Hernández et al.   JOURNAL OF CELL SCIENCE

Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury

(2017) Stephanie B. Syc-Mazurek et al.   Molecular Neurodegeneration

Axon Death Pathways Converge on Axundead to Promote Functional and Structural Axon Disassembly

(2017) Lukas J. Neukomm et al.   NEURON

Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons

(2017) Derek S. Welsbie et al.   NEURON

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

In-vivo effects of intraocular and intracranial pressures on the lamina cribrosa microstructure

(2017) Bo Wang et al.   PLoS One

Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective

(2017) Jeffrey M. Harder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

(2017) Pete A. Williams et al.   SCIENCE

Optic Nerve Degeneration after Retinal Ischemia/Reperfusion in a Rodent Model

(2017) Marina Renner et al.   Frontiers in Cellular Neuroscience

JUN is important for ocular hypertension-induced retinal ganglion cell degeneration

(2017) Stephanie B Syc-Mazurek et al.   Cell Death & Disease

MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2

(2017) Lauren J Walker et al.   eLife

Nicotinamide and WLDS Act Together to Prevent Neurodegeneration in Glaucoma

(2017) Pete A. Williams et al.   Frontiers in Neuroscience

Complement Protein C3 Suppresses Axon Growth and Promotes Neuron Loss

(2017) Sheri L. Peterson et al.   Scientific Reports

Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies

(2016) David E. Clark et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling

(2016) David J. Simon et al.   CELL

The interaction between intracranial pressure, intraocular pressure and lamina cribrosal compression in glaucoma

(2016) Charles W McMonnies   Clinical and Experimental Optometry

Protective effect of P7C3 on retinal ganglion cells from optic nerve injury

(2016) Hidehiro Oku et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

Attenuation of Axonal Degeneration by Calcium Channel Inhibitors Improves Retinal Ganglion Cell Survival and Regeneration After Optic Nerve Crush

(2016) Vinicius T. Ribas et al.   MOLECULAR NEUROBIOLOGY

C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury

(2016) Sean M. Silverman et al.   Molecular Neurodegeneration

Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

(2016) Pete A. Williams et al.   Molecular Neurodegeneration

In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells

(2016) Byung-Jin Kim et al.   Molecular Neurodegeneration

Axon injury induced endoplasmic reticulum stress and neurodegeneration

(2016) Yang Hu   Neural Regeneration Research

An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2

(2016) Yuya Yamagishi et al.   Cell Reports

C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy

(2016) Rhona McGonigal et al.   Acta Neuropathologica Communications

Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit

(2015) Jing Yang et al.   CELL

Live Imaging of Calcium Dynamics during Axon Degeneration Reveals Two Functionally Distinct Phases of Calcium Influx

(2015) M. E. Vargas et al.   JOURNAL OF NEUROSCIENCE

Characteristic Patterns of Dendritic Remodeling in Early-Stage Glaucoma: Evidence from Genetically Identified Retinal Ganglion Cell Types

(2015) R. N. El-Danaf et al.   JOURNAL OF NEUROSCIENCE

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

(2014) Gelin Wang et al.   CELL

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

(2014) M Di Stefano et al.   CELL DEATH AND DIFFERENTIATION

Role of C/EBP Homologous Protein in Retinal Ganglion Cell Death After Ischemia/Reperfusion Injury

(2014) S. Nashine et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models

(2014) Snahel Patel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Calcium Release from Intra-Axonal Endoplasmic Reticulum Leads to Axon Degeneration through Mitochondrial Dysfunction

(2014) R. Villegas et al.   JOURNAL OF NEUROSCIENCE

SkpA Restrains Synaptic Terminal Growth during Development and Promotes Axonal Degeneration following Injury

(2014) E. J. Brace et al.   JOURNAL OF NEUROSCIENCE

DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury

(2014) Kimberly A. Fernandes et al.   NEUROBIOLOGY OF DISEASE

Diverse cellular and molecular modes of axon degeneration

(2014) Lukas J. Neukomm et al.   TRENDS IN CELL BIOLOGY

Neuronal endoplasmic reticulum stress in axon injury and neurodegeneration

(2013) Shaohua Li et al.   ANNALS OF NEUROLOGY

From Mechanosensitivity to Inflammatory Responses: New Players in the Pathology of Glaucoma

(2013) David Križaj et al.   CURRENT EYE RESEARCH

JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells

(2013) Kimberly A. Fernandes et al.   EXPERIMENTAL EYE RESEARCH

Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model

(2013) Lioba Horstmann et al.   Journal of Neuroinflammation

Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice

(2013) Gareth R Howell et al.   Journal of Neuroinflammation

Calcium Influx and Calpain Activation Mediate Preclinical Retinal Neurodegeneration in Autoimmune Optic Neuritis

(2013) Dorit B. Hoffmann et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Ciliary neurotrophic factor and fibroblast growth factor increase the speed and number of regenerating axons after optic nerve injury in adultRana pipiens

(2013) Giam S. Vega-Meléndez et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy

(2013) Jason D. Dapper et al.   NEUROBIOLOGY OF DISEASE

Role of calpains in the injury-induced dysfunction and degeneration of the mammalian axon

(2013) Marek Ma   NEUROBIOLOGY OF DISEASE

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury

(2013) T. A. Watkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

(2013) D. S. Welsbie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration

(2013) Y Kitaoka et al.   Cell Death & Disease

Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning

(2013) Corey L. Cusack et al.   Nature Communications

The Phr1 Ubiquitin Ligase Promotes Injury-Induced Axon Self-Destruction

(2013) Elisabetta Babetto et al.   Cell Reports

A Caspase Cascade Regulating Developmental Axon Degeneration

(2012) D. J. Simon et al.   JOURNAL OF NEUROSCIENCE

JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death

(2012) Kimberly A. Fernandes et al.   NEUROBIOLOGY OF DISEASE

CHOP Potentially Co-Operates with FOXO3a in Neuronal Cells to Regulate PUMA and BIM Expression in Response to ER Stress

(2012) Arindam P. Ghosh et al.   PLoS One

The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

(2012) Xin Xiong et al.   PLOS BIOLOGY

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma

(2011) Gareth R. Howell et al.   JOURNAL OF CLINICAL INVESTIGATION

The Polymodal Ion Channel Transient Receptor Potential Vanilloid 4 Modulates Calcium Flux, Spiking Rate, and Apoptosis of Mouse Retinal Ganglion Cells

(2011) D. A. Ryskamp et al.   JOURNAL OF NEUROSCIENCE

Involvement of Caspase-6 and Caspase-8 in Neuronal Apoptosis and the Regenerative Failure of Injured Retinal Ganglion Cells

(2011) P. P. Monnier et al.   JOURNAL OF NEUROSCIENCE

Axonal degeneration, regeneration and ganglion cell death in a rodent model of anterior ischemic optic neuropathy (rAION)

(2010) Cheng Zhang et al.   EXPERIMENTAL EYE RESEARCH

Early microglia activation in a mouse model of chronic glaucoma

(2010) Alejandra Bosco et al.   JOURNAL OF COMPARATIVE NEUROLOGY

LRRK2 and the Stress Response: Interaction with MKKs and JNK-Interacting Proteins

(2010) C.H. Hsu et al.   Neurodegenerative Diseases

Mechanisms of acute axonal degeneration in the optic nerve in vivo

(2010) J. Knoferle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

(2010) Jonathan Gilley et al.   PLOS BIOLOGY

The NMN/NaMN adenylyltransferase (NMNAT) protein family

(2009) Corinna Lau   Frontiers in Bioscience-Landmark

Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis

(2008) Kenneth S. Shindler et al.   EXPERIMENTAL EYE RESEARCH

Retinal p75 and bax overexpression is associated with retinal ganglion cells apoptosis in a rat model of glaucoma

(2008) Marco Coassin et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Up-regulation of brain-derived neurotrophic factor by application of fibroblast growth factor-2 to the cut optic nerve is important for long-term survival of retinal ganglion cells

(2008) Rosa E. Blanco et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Elevated pressure triggers a physiological release of ATP from the retina: Possible role for pannexin hemichannels

(2008) D. Reigada et al.   NEUROSCIENCE