Future directions of glaucoma treatment: emerging gene, neuroprotection, nanomedicine, stem cell, and vascular therapies

Targeted Microglial Attenuation through Dendrimer–Drug Conjugates Improves Glaucoma Neuroprotection

(2023) Ian Pitha et al.   Biomacromolecules

Neuroserpin gene therapy inhibits retinal ganglion cell apoptosis and promotes functional preservation in glaucoma

(2023) Nitin Chitranshi et al.   MOLECULAR THERAPY

Cell-Specific Expression of Human SIRT1 by Gene Therapy Reduces Retinal Ganglion Cell Loss Induced by Elevated Intraocular Pressure

(2023) Jipeng Yue et al.   Neurotherapeutics

Matrix metalloproteinase-3 (MMP-3)–mediated gene therapy for glaucoma

(2023) Jeffrey O’Callaghan et al.   Science Advances

Exploring a Novel Fasudil-Phospholipid Complex Formulated as Liposomal Thermosensitive in situ Gel for Glaucoma

(2022) Aya M Khallaf et al.   International Journal of Nanomedicine

Animal models and drug candidates for use in glaucoma filtration surgery: A systematic review

(2022) Ralph J.S. van Mechelen et al.   EXPERIMENTAL EYE RESEARCH

Evaluation of neuroprotective and immunomodulatory properties of mesenchymal stem cells in an ex vivo retinal explant model

(2022) Élodie Reboussin et al.   Journal of Neuroinflammation

A novel glaucoma approach: Stem cell regeneration of the trabecular meshwork

(2022) Sara J. Coulon et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma

(2022) Milica A. Margeta et al.   IMMUNITY

Prostaglandin-based rAAV-mediated glaucoma gene therapy in Brown Norway rats

(2022) Kristina J. Chern et al.   Communications Biology

Vision protection and robust axon regeneration in glaucoma models by membrane-associated Trk receptors

(2022) Euido Nishijima et al.   MOLECULAR THERAPY

Retinal function after intravitreal injection of autologous bone marrow-derived mesenchymal stromal cells in advanced glaucoma

(2021) Carolina Assis P. Vilela et al.   DOCUMENTA OPHTHALMOLOGICA

Neuroprotective factors of the retina and their role in promoting survival of retinal ganglion cells: a review

(2021) Ewa Fudalej et al.   OPHTHALMIC RESEARCH

Looking into the future: Gene and cell therapies for glaucoma

(2021) András M. Komáromy et al.   VETERINARY OPHTHALMOLOGY

Protective effects of human umbilical cord mesenchymal stem cells on retinal ganglion cells in mice with acute ocular hypertension

(2021) Rui Liu et al.   International Journal of Ophthalmology

Stem cell transplantation rescued a primary open-angle glaucoma mouse model

(2021) Siqi Xiong et al.   eLife

The Role of Neuroinflammation in Glaucoma: An Update on Molecular Mechanisms and New Therapeutic Options

(2021) Teresa Rolle et al.   Frontiers in Neurology

Transplantation of miPSC/mESC-derived Retinal Ganglion Cells into healthy and glaucomatous retinas

(2021) Julia Oswald et al.   Molecular Therapy-Methods & Clinical Development

Vascular Aspects in Glaucoma: From Pathogenesis to Therapeutic Approaches

(2021) Anna-Sophie Mursch-Edlmayr et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Effect of Orally Administered Low-Dose Dronabinol on Retinal Blood Flow and Oxygen Metabolism in Healthy Subjects

(2021) Nikolaus Hommer et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Mesenchymal stem and non-stem cell surgery, rescue, and regeneration in glaucomatous optic neuropathy

(2021) Paolo Giuseppe Limoli et al.   Stem Cell Research & Therapy

Uptake and Distribution of Administered Bone Marrow Mesenchymal Stem Cell Extracellular Vesicles in Retina

(2021) Biji Mathew et al.   Cells

Novel Thiol Containing Hybrid Antioxidant-Nitric Oxide Donor Small Molecules for Treatment of Glaucoma

(2021) Charles E. Amankwa et al.   Antioxidants

XIAP gene therapy effects on retinal ganglion cell structure and function in a mouse model of glaucoma

(2021) Shagana Visuvanathan et al.   GENE THERAPY

Transplantation of reprogrammed peripheral blood cells differentiates into retinal ganglion cells in the mouse eye with NMDA‐induced injury

(2021) Xuezhi Zhou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

BCLXL gene therapy moderates neuropathology in the DBA/2J mouse model of inherited glaucoma

(2021) Ryan J. Donahue et al.   Cell Death & Disease

Stem Cell-Based Regeneration and Restoration for Retinal Ganglion Cell: Recent Advancements and Current Challenges

(2021) Jingxue Zhang et al.   Biomolecules

Cell-Based Therapies for Trabecular Meshwork Regeneration to Treat Glaucoma

(2021) Shayshadri Mallick et al.   Biomolecules

Glaucoma Clinical Research: Trends in Treatment Strategies and Drug Development

(2021) Line Storgaard et al.   Frontiers in Medicine

Phase 1b Randomized Controlled Study of Short Course Topical Recombinant Human Nerve Growth Factor (rhNGF) for Neuroenhancement in Glaucoma: Safety, Tolerability, and Efficacy Measure Outcomes

(2021) Gala Beykin et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

The Future of Stem Cells and Their Derivates in the Treatment of Glaucoma. A Critical Point of View

(2021) Simona Delia Nicoară et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma

(2021) Carlos Gustavo De Moraes et al.   JAMA Ophthalmology

Human Umbilical Cord-Mesenchymal Stem Cells Survive and Migrate within the Vitreous Cavity and Ameliorate Retinal Damage in a Novel Rat Model of Chronic Glaucoma

(2021) Yao Wang et al.   Stem Cells International

The Effect of Orally Administered Dronabinol on Optic Nerve Head Blood Flow in Healthy Subjects—A Randomized Clinical Trial

(2020) Nikolaus Hommer et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Gene Therapy for Glaucoma by Ciliary Body Aquaporin 1 Disruption Using CRISPR-Cas9

(2020) Jiahui Wu et al.   MOLECULAR THERAPY

Adipose‐derived stem cells integrate into trabecular meshwork with glaucoma treatment potential

(2020) Yi Zhou et al.   FASEB JOURNAL

Two-step induction of trabecular meshwork cells from induced pluripotent stem cells for glaucoma

(2020) Ajay Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3 ) supplementation: A crossover randomized clinical trial

(2020) Flora Hui et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Effect of connective tissue growth factor gene editing using adeno-associated virus–mediated CRISPR–Cas9 on rabbit glaucoma filtering surgery outcomes

(2020) Eun Jung Lee et al.   GENE THERAPY

Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1)

(2020) Felipe A. Medeiros et al.   OPHTHALMOLOGY

Ocular Perfusion Pressure and the Risk of Open-Angle Glaucoma: Systematic Review and Meta-analysis

(2020) Ko Eun Kim et al.   Scientific Reports

Time-course Changes in Optic Nerve Head Blood Flow and Retinal Nerve Fiber Layer Thickness in Eyes with Open-angle Glaucoma

(2020) Naoki Kiyota et al.   OPHTHALMOLOGY

Neuroprotection in Glaucoma: Towards Clinical Trials and Precision Medicine

(2019) Tasneem Z. Khatib et al.   CURRENT EYE RESEARCH

A review of systemic medications that may modulate the risk of glaucoma

(2019) Annie Wu et al.   EYE

A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma

(2019) Anitha Krishnan et al.   Journal of Neuroinflammation

Nanotechnology for Medical and Surgical Glaucoma Therapy—A Review

(2019) Marcelo Luís Occhiutto et al.   ADVANCES IN THERAPY

Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of Glaucoma

(2019) C. Randall Harrell et al.   Stem Cells International

Nerve Growth Factor: Early Studies And Recent Clinical Trials

(2018) Maria Luisa Rocco et al.   Current Neuropharmacology

Rho Kinase Inhibitors as a Novel Treatment for Glaucoma and Ocular Hypertension

(2018) Angelo P. Tanna et al.   OPHTHALMOLOGY

Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a Pilot study

(2018) Anna Sophie Mursch-Edlmayr et al.   Scientific Reports

Topical Curcumin Nanocarriers are Neuroprotective in Eye Disease

(2018) Benjamin M. Davis et al.   Scientific Reports

Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma

(2018) Alejandra Bosco et al.   MOLECULAR THERAPY

Improving Stem Cell Delivery to the Trabecular Meshwork Using Magnetic Nanoparticles

(2018) E. J. Snider et al.   Scientific Reports

Effects of ripasudil, a rho kinase inhibitor, on blood flow in the optic nerve head of normal rats

(2018) Yasushi Wada et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Effect of Ciliary Neurotrophic Factor on Retinal Neurodegeneration in Patients with Macular Telangiectasia Type 2

(2018) Emily Y. Chew et al.   OPHTHALMOLOGY

Intracameral Delivery of Layer‐by‐Layer Coated siRNA Nanoparticles for Glaucoma Therapy

(2018) Andrea E. Dillinger et al.   Small

Transplantation of retinal progenitor cells from optic cup-like structures differentiated from human embryonic stem cells in vitro and in vivo generation of retinal ganglion-like cells

(2018) Songtao Wang et al.   STEM CELLS AND DEVELOPMENT

Six month delivery of GDNF from PLGA/vitamin E biodegradable microspheres after intravitreal injection in rabbits

(2017) Cristina García-Caballero et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

RES-loaded pegylated CS NPs: for efficient ocular delivery

(2017) Saravanakumar Pandian et al.   IET Nanobiotechnology

Co-encapsulated resveratrol and quercetin in chitosan and peg modified chitosan nanoparticles: For efficient intra ocular pressure reduction

(2017) Subramanian Natesan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Effects of ripasudil hydrochloride hydrate (K-115), a Rho-kinase inhibitor, on ocular blood flow and ciliary artery smooth muscle contraction in rabbits

(2017) Yusuke Ohta et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

Glaucoma as a Metabolic Optic Neuropathy

(2017) Pete A. Williams et al.   JOURNAL OF GLAUCOMA

CRISPR-Cas9–based treatment of myocilin-associated glaucoma

(2017) Ankur Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

(2017) Pete A. Williams et al.   SCIENCE

Bone Marrow-Derived Mesenchymal Stem Cells-Derived Exosomes Promote Survival of Retinal Ganglion Cells Through miRNA-Dependent Mechanisms

(2017) Ben Mead et al.   Stem Cells Translational Medicine

Nicotinamide and WLDS Act Together to Prevent Neurodegeneration in Glaucoma

(2017) Pete A. Williams et al.   Frontiers in Neuroscience

First-in-human phase I study of ISTH0036, an antisense oligonucleotide selectively targeting transforming growth factor beta 2 (TGF-β2), in subjects with open-angle glaucoma undergoing glaucoma filtration surgery

(2017) Norbert Pfeiffer et al.   PLoS One

Ocular blood flow in glaucoma - the Leuven Eye Study

(2016) Luís Abegão Pinto et al.   ACTA OPHTHALMOLOGICA

Mesenchymal stromal cell–mediated neuroprotection and functional preservation of retinal ganglion cells in a rodent model of glaucoma

(2016) Ben Mead et al.   CYTOTHERAPY

Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma

(2016) Anitha Krishnan et al.   JOURNAL OF IMMUNOLOGY

Virus-mediated EpoR76E gene therapy preserves vision in a glaucoma model by modulating neuroinflammation and decreasing oxidative stress

(2016) Jessica Hines-Beard et al.   Journal of Neuroinflammation

Stem Cells in the Trabecular Meshwork for Regulating Intraocular Pressure

(2016) Hongmin Yun et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Virus-mediated EpoR76E Therapy Slows Optic Nerve Axonopathy in Experimental Glaucoma

(2016) Wesley S Bond et al.   MOLECULAR THERAPY

Transplantation of iPSC-derived TM cells rescues glaucoma phenotypes in vivo

(2016) Wei Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroprotective effects of intravitreally transplanted adipose tissue and bone marrow–derived mesenchymal stem cells in an experimental ocular hypertension model

(2015) Esra Emre et al.   CYTOTHERAPY

The Most Common Barriers to Glaucoma Medication Adherence

(2015) Paula Anne Newman-Casey et al.   OPHTHALMOLOGY

Continuous Non-Cell Autonomous Reprogramming to Generate Retinal Ganglion Cells for Glaucomatous Neuropathy

(2015) Sowmya Parameswaran et al.   STEM CELLS

Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma

(2015) Christophe Roubeix et al.   Stem Cell Research & Therapy

Prospects for Lentiviral Vector Mediated Prostaglandin F Synthase Gene Delivery in Monkey EyesIn vivo

(2014) Eun Suk Lee et al.   CURRENT EYE RESEARCH

AAV-mediated and pharmacological induction of Hsp70 expression stimulates survival of retinal ganglion cells following axonal injury

(2014) J M K Kwong et al.   GENE THERAPY

Inhibitor of Apoptosis-Stimulating Protein of p53 (iASPP) Is Required for Neuronal Survival after Axonal Injury

(2014) Ariel M. Wilson et al.   PLoS One

Toxicological and Pharmacokinetic Properties of QPI-1007, a Chemically Modified Synthetic siRNA Targeting Caspase 2 mRNA, Following Intravitreal Injection

(2014) Elisabeth C.R. Solano et al.   Nucleic Acid Therapeutics

Phase I Clinical Trial of SYL040012, a Small Interfering RNA Targeting β-Adrenergic Receptor 2, for Lowering Intraocular Pressure

(2013) Javier Moreno-Montañés et al.   MOLECULAR THERAPY

Transplantation of Mesenchymal Stem Cells Promotes Tissue Regeneration in a Glaucoma Model Through Laser-Induced Paracrine Factor Secretion and Progenitor Cell Recruitment

(2013) Renaud Manuguerra-GagnÉ et al.   STEM CELLS

siRNA Silencing of Gene Expression in Trabecular Meshwork: RhoA siRNA Reduces IOP in Mice

(2012) Q. Liu et al.   CURRENT MOLECULAR MEDICINE

Challenges in neuroprotective nanomedicine development: progress towards noninvasive gene therapy of glaucoma

(2012) Samih Alqawlaq et al.   Nanomedicine

Glaucoma 2.0: Neuroprotection, Neuroregeneration, Neuroenhancement

(2012) Elma E. Chang et al.   OPHTHALMOLOGY

Silencing of P2Y2receptors reduces intraocular pressure in New Zealand rabbits

(2011) Alba Martin-Gil et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protective effects of catalase on retinal ischemia/reperfusion injury in rats

(2011) Baihua Chen et al.   EXPERIMENTAL EYE RESEARCH

Gene therapy for retinal ganglion cell neuroprotection in glaucoma

(2011) A M Wilson et al.   GENE THERAPY

Systemic Adeno-Associated Virus-Mediated Gene Therapy Preserves Retinal Ganglion Cells and Visual Function in DBA/2J Glaucomatous Mice

(2011) Timothy A. Sullivan et al.   HUMAN GENE THERAPY

Retinal ganglion cells survival in a glaucoma model by GDNF/Vit E PLGA microspheres prepared according to a novel microencapsulation procedure

(2011) Patricia Checa-Casalengua et al.   JOURNAL OF CONTROLLED RELEASE

Determinants of Medication Adherence to Topical Glaucoma Therapy

(2011) Laura E. Dreer et al.   JOURNAL OF GLAUCOMA

Opposing Roles for Membrane Bound and Soluble Fas Ligand in Glaucoma-Associated Retinal Ganglion Cell Death

(2011) Meredith S. Gregory et al.   PLoS One

Ocular Application of Nerve Growth Factor Protects Degenerating Retinal Ganglion Cells in a Rat Model of Glaucoma

(2010) Valeria Colafrancesco et al.   JOURNAL OF GLAUCOMA

Use of calcium channel blockers for glaucoma

(2010) Makoto Araie et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Ocular perfusion pressure and glaucoma: clinical trial and epidemiologic findings

(2009) M Cristina Leske   CURRENT OPINION IN OPHTHALMOLOGY

Prostaglandin Pathway Gene Therapy for Sustained Reduction of Intraocular Pressure

(2009) Román A Barraza et al.   MOLECULAR THERAPY

Experimental and clinical evidence of neuroprotection by nerve growth factor eye drops: Implications for glaucoma

(2009) A. Lambiase et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(lactic-co-glycolic acid) nanospheres and microspheres for short- and long-term delivery of bioactive ciliary neurotrophic factor

(2008) Michael K. Nkansah et al.   BIOTECHNOLOGY AND BIOENGINEERING

A Placebo-Controlled 3-Year Study of a Calcium Blocker on Visual Field and Ocular Circulation in Glaucoma with Low-Normal Pressure

(2008) Nobuyuki Koseki et al.   OPHTHALMOLOGY