Glaucoma Clinical Research: Trends in Treatment Strategies and Drug Development

Trabodenoson on trabecular meshwork rejuvenation: a comprehensive review of clinical data

(2021) Tina Guanting Qiu   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Adenosine receptors as promising targets for the management of ocular diseases

(2021) Eleonora Spinozzi et al.   MEDICINAL CHEMISTRY RESEARCH

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

(2021) James R. Tribble et al.   Redox Biology

Clinical outcomes of micropulse transscleral cyclophotocoagulation in refractory glaucoma—18 months follow-up

(2020) Maria Alexandra Preda et al.   LASERS IN MEDICAL SCIENCE

Keep an eye on adenosine: Its role in retinal inflammation

(2020) Ana Raquel Santiago et al.   PHARMACOLOGY & THERAPEUTICS

Cytidine 5′-Diphosphocholine (Citicoline): Evidence for a Neuroprotective Role in Glaucoma

(2020) Stefano Gandolfi et al.   Nutrients

Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3 ) supplementation: A crossover randomized clinical trial

(2020) Flora Hui et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Current Medical Therapy and Future Trends in the Management of Glaucoma Treatment

(2020) Barbara Cvenkel et al.   Journal of Ophthalmology

Inflammation in Glaucoma: From the back to the front of the eye, and beyond

(2020) Christophe Baudouin et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Effects of Citicoline, Homotaurine, and Vitamin E on Contrast Sensitivity and Visual-Related Quality of Life in Patients with Primary Open-Angle Glaucoma: A Preliminary Study

(2020) Pier Marino et al.   MOLECULES

Primary Open-Angle Glaucoma Suspect Preferred Practice Pattern®

(2020) Steven J. Gedde et al.   OPHTHALMOLOGY

Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development

(2019) Kenneth A. Jacobson et al.   Frontiers in Cellular Neuroscience

Nitric oxide: a drug target for glaucoma revisited

(2019) Gerhard Garhöfer et al.   DRUG DISCOVERY TODAY

Cholinergic nervous system and glaucoma: From basic science to clinical applications

(2019) Muneeb A. Faiq et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Neuroprotection in Glaucoma: Towards Clinical Trials and Precision Medicine

(2019) Tasneem Z. Khatib et al.   CURRENT EYE RESEARCH

Rho-kinase inhibitors in the management of glaucoma

(2019) Emanuela Berrino et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Effects of TAK-639, a novel topical C-type natriuretic peptide analog, on intraocular pressure and aqueous humor dynamics in mice

(2019) J. Cameron Millar et al.   EXPERIMENTAL EYE RESEARCH

Pharmacokinetics and intraocular pressure–lowering activity of TAK-639, a novel C-type natriuretic peptide analog, in rabbit, dog, and monkey

(2019) Anneli Savinainen et al.   EXPERIMENTAL EYE RESEARCH

Estimation of clinical trial success rates and related parameters

(2018) Chi Heem Wong et al.   BIOSTATISTICS

Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury

(2018) Jessica Agostinone et al.   BRAIN

Preservatives in glaucoma medication

(2018) David W Steven et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Prostaglandin analogues and nitric oxide contribution in the treatment of ocular hypertension and glaucoma

(2018) Francesco Impagnatiello et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Current Status of Drug Discovery and Development as Originated in US Academia: The Influence of Industrial and Academic Collaboration on Drug Discovery and Development

(2018) Tohru Takebe et al.   CTS-Clinical and Translational Science

Citicoline and Retinal Ganglion Cells: Effects on Morphology and Function

(2018) Vincenzo Parisi et al.   Current Neuropharmacology

Impact of the clinical use of ROCK inhibitor on the pathogenesis and treatment of glaucoma

(2018) Megumi Honjo et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl

(2018) RYO IWAMURA et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma

(2018) Anthony P. Khawaja et al.   NATURE GENETICS

Oral Memantine for the Treatment of Glaucoma

(2018) Robert N. Weinreb et al.   OPHTHALMOLOGY

Omidenepag Isopropyl Ophthalmic Solution 0.002%: First Global Approval

(2018) Sean Duggan   DRUGS

Clinical trials

(2018) Peter C. Minneci et al.   Seminars in Pediatric Surgery

Neuroinflammation in glaucoma: A new opportunity

(2017) Pete A. Williams et al.   EXPERIMENTAL EYE RESEARCH

Ocular Hypotensive Effect of ONO-9054, an EP3/FP Receptor Agonist

(2016) Alon Harris et al.   JOURNAL OF GLAUCOMA

Drug discovery in ophthalmology: past success, present challenges, and future opportunities

(2016) Nicholas J. D. Gower et al.   BMC Ophthalmology

EP3/FP dual receptor agonist ONO-9054 administered morning or evening to patients with open-angle glaucoma or ocular hypertension: results of a randomised crossover study

(2015) Michael S Berlin et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Treatment with citicoline eye drops enhances retinal function and neural conduction along the visual pathways in open angle glaucoma

(2015) Vincenzo Parisi et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Neuroprotective therapies for glaucoma

(2015) Wei Song et al.   Drug Design Development and Therapy

The Prevalence and Incidence of Glaucoma in Denmark in a Fifteen Year Period: A Nationwide Study

(2015) Miriam Kolko et al.   PLoS One

Ripasudil: First Global Approval

(2014) Karly P. Garnock-Jones   DRUGS

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Challenges in the development of glaucoma neuroprotection therapy

(2013) Yang Liu et al.   CELL AND TISSUE RESEARCH

Effects of Prostaglandin Analogues on Aqueous Humor Outflow Pathways

(2013) Nelson S. Winkler et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

The Role of Inflammation in the Pathogenesis of Glaucoma

(2013) Rupali Vohra et al.   SURVEY OF OPHTHALMOLOGY

Glaucoma management: relative value and place in therapy of available drug treatments

(2013) Deepak Sambhara et al.   Therapeutic Advances in Chronic Disease

Quantitative OCT angiography of optic nerve head blood flow

(2012) Yali Jia et al.   Biomedical Optics Express

Regulation of research: Is it a drug trial or a supplement trial?

(2010) Shaw T. Chen   FITOTERAPIA

A History of Glaucoma Pharmacology

(2010) Tony Realini   OPTOMETRY AND VISION SCIENCE

Preservatives in eyedrops: The good, the bad and the ugly

(2010) Christophe Baudouin et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Pharmacotherapy of intraocular pressure – part II. Carbonic anhydrase inhibitors, prostaglandin analogues and prostamides

(2009) Ciro Costagliola et al.   EXPERT OPINION ON PHARMACOTHERAPY

Current concepts in the pathophysiology of glaucoma

(2009) SureshK Gupta et al.   INDIAN JOURNAL OF OPHTHALMOLOGY

Brain-derived neurotrophic factor in neurodegenerative diseases

(2009) Chiara Zuccato et al.   Nature Reviews Neurology

Update on the Mechanism of Action of Topical Prostaglandins for Intraocular Pressure Reduction

(2008) Carol B. Toris et al.   SURVEY OF OPHTHALMOLOGY