Elemene Antitumor Drugs Development Based on “Molecular Compatibility Theory” and Clinical Application: A Retrospective and Prospective Outlook

Combination of chemotherapy and gaseous signaling molecular therapy: Novel β‐elemene nitric oxide donor derivatives against leukemia

(2023) Junlong Zhu et al.   DRUG DEVELOPMENT RESEARCH

Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis

(2023) Xiaoying Jiang et al.   MEDICINAL RESEARCH REVIEWS

Second generation β-elemene nitric oxide derivatives with reasonable linkers: potential hybrids against malignant brain glioma

(2022) Renren Bai et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

β‐Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts

(2022) Qin Guo et al.   IUBMB LIFE

Small Molecule‐Induced Differentiation As a Potential Therapy for Liver Cancer

(2022) Xu Zhang et al.   Advanced Science

β-Elemene alleviates cisplatin resistance in oral squamous cell carcinoma cell via inhibiting JAK2/STAT3 pathway in vitro and in vivo

(2022) Haiye Wang et al.   Cancer Cell International

β-elemene Isopropanolamine Derivative LXX-8250 Induces Apoptosis Through Impairing Autophagic Flux via PFKFB4 Repression in Melanoma Cells

(2022) Sajid Jalal et al.   Frontiers in Pharmacology

Design, synthesis and antitumor efficacy evaluation of a series of novel β-elemene-based macrocycles

(2022) Xiang Qi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel hydroxyl carboximates derived from β-elemene: design, synthesis and anti-tumour activities evaluation

(2022) Yuan Gao et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Nanoheterojunction‐Mediated Thermoelectric Strategy for Cancer Surgical Adjuvant Treatment and β‐elemene Combination Therapy

(2022) Xiaoyuan Ji et al.   ADVANCED MATERIALS

β-elemene induced apoptosis and senescence of triple-negative breast cancer cells through IGF1/IGF1R pathway

(2022) Lufan Xie et al.   TISSUE & CELL

FBP1 induced by β‐elemene enhances the sensitivity of gefitinib in lung cancer

(2022) Jian Li et al.   Thoracic Cancer

Stanene‐Based Nanosheets for β‐Elemene Delivery and Ultrasound‐Mediated Combination Cancer Therapy

(2021) Wei Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anti-Tumor Drug Discovery Based on Natural Product β-Elemene: Anti-Tumor Mechanisms and Structural Modification

(2021) Ziqiang Bai et al.   MOLECULES

β-elemene affects angiogenesis of infantile hemangioma by regulating angiotensin-converting enzyme 2 and hypoxia-inducible factor-1 alpha

(2021) Zhenyu Wang et al.   Journal of Natural Medicines

Arsenene Nanodots with Selective Killing Effects and their Low‐Dose Combination with ß‐Elemene for Cancer Therapy

(2021) Chuang Liu et al.   ADVANCED MATERIALS

Terpenoids from Curcumae Rhizoma: Their anticancer effects and clinical uses on combination and versus drug therapies

(2021) Yi Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

β‑elemene inhibits non‑small cell lung cancer cell migration and invasion by inactivating the FAK‑Src pathway

(2021) Hongbo Zhang et al.   Experimental and Therapeutic Medicine

Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review

(2021) Tiantian Tan et al.   MOLECULES

Active targeting of orthotopic glioma using biomimetic liposomes co-loaded elemene and cabazitaxel modified by transferritin

(2021) Jie Li et al.   JOURNAL OF NANOBIOTECHNOLOGY

β-Elemene Inhibits the Metastasis of Multidrug-Resistant Gastric Cancer Cells Through miR-1323/Cbl-b/EGFR Pathway

(2020) Mingming Deng et al.   PHYTOMEDICINE

The Antitumor Efficacy of β-Elemene by Changing Tumor Inflammatory Environment and Tumor Microenvironment

(2020) Qiang Xie et al.   Biomed Research International

β-Elemene Reverses the Resistance of p53-Deficient Colorectal Cancer Cells to 5-Fluorouracil by Inducing Pro-death Autophagy and Cyclin D3-Dependent Cycle Arrest

(2020) Ruonan Zhang et al.   Frontiers in Bioengineering and Biotechnology

β-Elemene Enhances the Chemotherapeutic Effect of 5-Fluorouracil in Triple-Negative Breast Cancer via PI3K/AKT, RAF-MEK-ErK, and NF-κB Signaling Pathways

(2020) Pengyu Su et al.   OncoTargets and Therapy

Beta-elemene inhibits differentiated thyroid carcinoma metastasis by reducing cellular proliferation, metabolism and invasion ability

(2020) Lei Zhao et al.   Annals of Translational Medicine

Regulation of signaling pathways by β‐elemene in cancer progression and metastasis

(2019) Muhammad Z. Qureshi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science

(2019) Yuening Xiang et al.   Cancer Medicine

Beta‐elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation

(2019) Yanhong Pan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cytotoxic effects of a sesquiterpene β-elemene on THP-1 leukemia cells is mediated via crosstalk between beclin-1 mediated autophagy and caspase-dependent apoptosis

(2019) Ziyu Jiang et al.   PROCESS BIOCHEMISTRY

β-elemene attenuates macrophage activation and proinflammatory factor production via crosstalk with Wnt/β-catenin signaling pathway

(2018) Yangyi Fang et al.   FITOTERAPIA

β-elemene against Burkitt’s lymphoma via activation of PUMA mediated apoptotic pathway

(2018) Tonglin Hu et al.   BIOMEDICINE & PHARMACOTHERAPY

The protective effects of a novel synthetic β-elemene derivative on human umbilical vein endothelial cells against oxidative stress-induced injury: Involvement of antioxidation and PI3k/Akt/eNOS/NO signaling pathways

(2018) Khalil Ali Ahmad et al.   BIOMEDICINE & PHARMACOTHERAPY

Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy

(2018) Bingtao Zhai et al.   International Journal of Nanomedicine

Discovery of novel antitumor nitric oxide-donating β -elemene hybrids through inhibiting the PI3K/Akt pathway

(2017) Jichao Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel hybrids of natural β -elemene bearing isopropanolamine moieties: Synthesis, enhanced anticancer profile, and improved aqueous solubility

(2017) Jichao Chen et al.   FITOTERAPIA

Antioxidant Properties of Novel Dimers Derived from Natural β-Elemene through Inhibiting H2O2-Induced Apoptosis

(2017) Jichao Chen et al.   ACS Medicinal Chemistry Letters

Interplay of DNA methyltransferase 1 and EZH2 through inactivation of Stat3 contributes to β-elemene-inhibited growth of nasopharyngeal carcinoma cells

(2017) JingJing Wu et al.   Scientific Reports

β-Elemene Inhibits Cell Proliferation by Regulating the Expression and Activity of Topoisomerases I and IIαin Human Hepatocarcinoma HepG-2 Cells

(2015) Min Gong et al.   Biomed Research International

Design, synthesis and antioxidant activity evaluation of novel β-elemene derivatives

(2014) Jichao Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

β-elemene inhibits stemness, promotes differentiation and impairs chemoresistance to temozolomide in glioblastoma stem-like cells

(2014) TING-ZHUN ZHU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

ETME, a novel β-elemene derivative, synergizes with arsenic trioxide in inducing apoptosis and cell cycle arrest in hepatocarcinoma cells via a p53-dependent pathway

(2014) Zhiying Yu et al.   Acta Pharmaceutica Sinica B

Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells

(2013) Zhi-Jun Dai et al.   Cancer Cell International

β-Elemene-Attenuated Tumor Angiogenesis by Targeting Notch-1 in Gastric Cancer Stem-Like Cells

(2013) Bing Yan et al.   Evidence-based Complementary and Alternative Medicine

13,14-bis(cis-3,5-dimethyl-1-piperazinyl)-β-elemene, a novel β-elemene derivative, shows potent antitumor activities via inhibition of mTOR in human breast cancer cells

(2013) XIAO-FEI DING et al.   Oncology Letters

β-Elemene induces apoptosis as well as protective autophagy in human non-small-cell lung cancer A549 cells

(2011) Jing Liu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

β-Elemene Piperazine Derivatives Induce Apoptosis in Human Leukemia Cells through Downregulation of c-FLIP and Generation of ROS

(2011) Zhiying Yu et al.   PLoS One

Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis

(2010) Wenxing Chen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

N-(β-Elemene-13-yl)tryptophan methyl ester induces apoptosis in human leukemia cells and synergizes with arsenic trioxide through a hydrogen peroxide dependent pathway

(2008) Zhiying Yu et al.   CANCER LETTERS