β-Elemene Enhances the Chemotherapeutic Effect of 5-Fluorouracil in Triple-Negative Breast Cancer via PI3K/AKT, RAF-MEK-ErK, and NF-κB Signaling Pathways

Mechanism of bioactive polysaccharide from Lachnum sp. acts synergistically with 5-fluorouracil against human hepatocellular carcinoma

(2019) Shuai Zong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ficus virens proanthocyanidins induced apoptosis in breast cancer cells concomitantly ameliorated 5-fluorouracil induced intestinal mucositis in rats

(2017) Xiao-Xin Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

Elemene inhibits the migration and invasion of 4T1 murine breast cancer cells via heparanase

(2017) Yi Zhang et al.   Molecular Medicine Reports

Elemene Induces Apoptosis of Human Gastric Cancer Cell Line BGC-823 via Extracellular Signal-Regulated Kinase (ERK) 1/2 Signaling Pathway

(2017) Pihong Li et al.   MEDICAL SCIENCE MONITOR

Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress

(2017) Amara Maryam et al.   Scientific Reports

Targeting Inflammation in Cancer Prevention and Therapy

(2016) J. Todoric et al.   Cancer Prevention Research

Ghrelin induces colon cancer cell proliferation through the GHS-R, Ras, PI3K, Akt, and mTOR signaling pathways

(2016) Gi-Shih Lien et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-inflammatory effects of royal poinciana through inhibition of toll-like receptor 4 signaling pathway

(2016) Satyajit Patra et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Upregulation of Akt/NF-κB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle

(2016) Bo Tang et al.   International Journal of Nanomedicine

Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-κB/iNOS signaling pathways

(2016) Yue Gao et al.   JOURNAL OF PINEAL RESEARCH

Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?

(2016) S Baig et al.   Cell Death & Disease

Apoptotic pathways as a therapeutic target for colorectal cancer treatment

(2016) Aman M Abraha et al.   World Journal of Gastrointestinal Oncology

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

(2016) Linda S. Steelman et al.   Aging-US

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Metabolic therapy: A new paradigm for managing malignant brain cancer

(2015) Thomas N. Seyfried et al.   CANCER LETTERS

β-Elemene Reverses Chemoresistance of Breast Cancer Cells by Reducing Resistance Transmission via Exosomes

(2015) Jun Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Current mechanistic insights into the roles of matrix metalloproteinases in tumour invasion and metastasis

(2015) Gordon T Brown et al.   JOURNAL OF PATHOLOGY

Apoptosis, Necrosis, and Necroptosis in the Gut and Intestinal Homeostasis

(2015) Anna Negroni et al.   MEDIATORS OF INFLAMMATION

Functional mechanism of the enhancement of 5-fluorouracil sensitivity by TUSC4 in colon cancer cells

(2015) MING-NA LIU et al.   Oncology Letters

Autophagy Protects Monocytes from Wolbachia Heat Shock Protein 60–Induced Apoptosis and Senescence

(2015) Vijayan Kamalakannan et al.   PLoS Neglected Tropical Diseases

Cancer metastases: challenges and opportunities

(2015) Xiangming Guan   Acta Pharmaceutica Sinica B

Mortality Characteristics and Prediction of Female Breast Cancer in China from 1991 to 2011

(2014) Xiao-Jun Shi et al.   Asian Pacific Journal of Cancer Prevention

Synergism of PI3K/Akt inhibition and Fas activation on colon cancer cell death

(2014) Liang Zhu et al.   CANCER LETTERS

COX-2 Signaling and Cancer: New Players in Old Arena

(2014) Shashank Misra et al.   CURRENT DRUG TARGETS

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Synergistic effects of puerarin combined with 5-fluorouracil on esophageal cancer

(2014) JUN WANG et al.   Molecular Medicine Reports

The Role of E3 Ubiquitin Ligase Cbl Proteins in β-Elemene Reversing Multi-Drug Resistance of Human Gastric Adenocarcinoma Cells

(2013) Ye Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sensitization of lung cancer cells to cisplatin by β-elemene is mediated through blockade of cell cycle progression: antitumor efficacies of β-elemene and its synthetic analogs

(2013) Q. Quentin Li et al.   MEDICAL ONCOLOGY

13,14-bis(cis-3,5-dimethyl-1-piperazinyl)-β-elemene, a novel β-elemene derivative, shows potent antitumor activities via inhibition of mTOR in human breast cancer cells

(2013) XIAO-FEI DING et al.   Oncology Letters

β-Elemene Induces Apoptosis in Human Renal-cell Carcinoma 786-0 Cells through Inhibition of MAPK/ERK and PI3K/Akt/mTOR Signalling Pathways

(2012) Yun-Hong Zhan et al.   Asian Pacific Journal of Cancer Prevention

Synergism between carnosic acid and arsenic trioxide on induction of acute myeloid leukemia cell apoptosis is associated with modulation of PTEN/Akt signaling pathway

(2012) Ran Wang et al.   Chinese Journal of Integrative Medicine

Targeting the MAPK–RAS–RAF signaling pathway in cancer therapy

(2012) Libero Santarpia et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Isoalantolactone Induces Reactive Oxygen Species Mediated Apoptosis in Pancreatic Carcinoma PANC-1 Cells

(2012) Muhammad Khan et al.   International Journal of Biological Sciences

Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae – A review

(2012) Jin-Jian Lu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

Reversion of Multidrug Resistance in a Chemoresistant Human Breast Cancer Cell Line by ß-Elemene

(2012) Hong-Bin Xu et al.   PHARMACOLOGY

The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation

(2012) Laura Tornatore et al.   TRENDS IN CELL BIOLOGY

β-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis

(2011) Jing Liu et al.   BMC CANCER

β-Elemene induces apoptosis as well as protective autophagy in human non-small-cell lung cancer A549 cells

(2011) Jing Liu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Activated PI3K/Akt/COX-2 Pathway Induces Resistance to Radiation in Human Cervical Cancer HeLa Cells

(2010) Shu Xia et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

The PI3K Pathway As Drug Target in Human Cancer

(2010) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

Structure of a Heterotetrameric Geranyl Pyrophosphate Synthase from Mint (Mentha piperita) Reveals Intersubunit Regulation

(2010) T.-H. Chang et al.   PLANT CELL

Roles of the NF- B Pathway in Lymphocyte Development and Function

(2009) S. Gerondakis et al.   Cold Spring Harbor Perspectives in Biology

The postoperative brain tumour stem cell (BTSC) niche and cancer recurrence

(2008) Jian-Min Liu et al.   ADVANCES IN THERAPY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE