β-Elemene Reverses the Resistance of p53-Deficient Colorectal Cancer Cells to 5-Fluorouracil by Inducing Pro-death Autophagy and Cyclin D3-Dependent Cycle Arrest

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Clarithromycin inhibits autophagy in colorectal cancer by regulating the hERG1 potassium channel interaction with PI3K

(2020) Giulia Petroni et al.   Cell Death & Disease

The Role of p53-Mediated Signaling in the Therapeutic Response of Colorectal Cancer to 9F, a Spermine-Modified Naphthalene Diimide Derivative

(2020) Lei Gao et al.   Cancers

Safety and Effectiveness of Aflibercept + Fluorouracil, Leucovorin, and Irinotecan (FOLFIRI) for the Treatment of Patients with Metastatic Colorectal Cancer (mCRC) in Current Clinical Practice: OZONE Study

(2020) Ian Chau et al.   Cancers

Expression and biological function of rhotekin in gastric cancer through regulating p53 pathway

(2019) Meng-Yao Sun et al.   Cancer Management and Research

Apoptotic Effect of Saccharomyces cerevisiae on Human Colon Cancer SW480 Cells by Regulation of Akt/NF-ĸB Signaling Pathway

(2019) Sara Shamekhi et al.   Probiotics and Antimicrobial Proteins

The multiple mechanisms that regulate p53 activity and cell fate

(2019) Antonina Hafner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism of bioactive polysaccharide from Lachnum sp. acts synergistically with 5-fluorouracil against human hepatocellular carcinoma

(2019) Shuai Zong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PD-016Health-related quality of life in RAS wild-type metastatic colorectal cancer patients treated with panitumumab plus FOLFOX followed by panitumumab or panitumumab plus 5-FU/LV maintenance: the secondary endpoint of the Valentino study

(2019) A Raimondi et al.   ANNALS OF ONCOLOGY

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

The atypical protein kinase RIOK3 contributes to glioma cell proliferation/survival, migration/invasion and the AKT/mTOR signaling pathway

(2018) Tong Zhang et al.   CANCER LETTERS

A cancer associated somatic mutation in LC3B attenuates its binding to E1-like ATG7 protein and subsequent lipidation

(2018) Gal Chaim Nuta et al.   Autophagy

Autophagy-independent induction of LC3B through oxidative stress reveals its non-canonical role in anoikis of ovarian cancer cells

(2018) Eswara Murali Satyavarapu et al.   Cell Death & Disease

Augmented antitumor activity of 5-fluorouracil by double knockdown of MDM4 and MDM2 in colon and gastric cancer cells

(2018) Mamiko Imanishi et al.   CANCER SCIENCE

Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy

(2018) Bingtao Zhai et al.   International Journal of Nanomedicine

Discovery of novel antitumor nitric oxide-donating β -elemene hybrids through inhibiting the PI3K/Akt pathway

(2017) Jichao Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cell Cycle-independent Role of Cyclin D3 in Host Restriction of Influenza Virus Infection

(2017) Ying Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of autophagy in regulating the radiosensitivity of tumor cells

(2017) Yong Xin et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival

(2017) Haizhen Wang et al.   NATURE

P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting

(2017) Prashanth Gokare et al.   Scientific Reports

Cancer statistics in China, 2015

(2016) Wanqing Chen et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Benefit of uridine triacetate (Vistogard) in rescuing severe 5-fluorouracil toxicity in patients with dihydropyrimidine dehydrogenase (DPYD) deficiency

(2016) Muhammad Wasif Saif et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Comparative efficacy of whole-brain radiotherapy with and without elemene liposomes in patients with multiple brain metastases from non-small-cell lung carcinoma

(2016) Y.N. Sun et al.   Current Oncology

β-Elemene enhances the efficacy of gefitinib on glioblastoma multiforme cells through the inhibition of the EGFR signaling pathway

(2016) Lin Mu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

An Autophagic Flux Probe that Releases an Internal Control

(2016) Takeshi Kaizuka et al.   MOLECULAR CELL

β-Elemene Selectively Inhibits the Proliferation of Glioma Stem-Like Cells Through the Downregulation of Notch1

(2016) Hai-bin Feng et al.   Stem Cells Translational Medicine

Crucial roles of thymidine kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2′-deoxy-5-fluorouridine into DNA

(2015) KAZUKI SAKAMOTO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Targeting cyclin D3/CDK6 activity for treatment of Parkinson's disease

(2015) Carolina Alquézar et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of tumor growth by β-elemene through downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9 in a murine intraocular melanoma model

(2015) Hong Shi et al.   MELANOMA RESEARCH

JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy

(2014) Xinbing Sui et al.   Scientific Reports

β-Elemene enhances susceptibility to cisplatin in resistant ovarian carcinoma cells via downregulation of ERCC-1 and XIAP and inactivation of JNK

(2013) QUENTIN Q. LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Sensitization of lung cancer cells to cisplatin by β-elemene is mediated through blockade of cell cycle progression: antitumor efficacies of β-elemene and its synthetic analogs

(2013) Q. Quentin Li et al.   MEDICAL ONCOLOGY

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells

(2012) Zhengzhi Zou et al.   Autophagy

Tumor Cell Autophagy as an Adaptive Response Mediating Resistance to Treatments Such as Antiangiogenic Therapy

(2012) Y.-L. Hu et al.   CANCER RESEARCH

p53 signaling and autophagy in cancer: A revolutionary strategy could be developed for cancer treatment

(2011) Xinbing Sui et al.   Autophagy

Cbl-regulated Akt and ERK signals are involved in β-elemene-induced cell apoptosis in lung cancer cells

(2011) Xuejun Hu   Molecular Medicine Reports

Autophagy as a target for anticancer therapy

(2011) Filip Janku et al.   Nature Reviews Clinical Oncology

Antineoplastic effect ofβ-elemene on prostate cancer cells and other types of solid tumour cells

(2010) Qingdi Quentin Li et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

An investigation of the ability of elemene to pass through the blood-brain barrier and its effect on brain carcinomas

(2009) Xue Shen Wu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Anti-tumor effect of β-elemene in glioblastoma cells depends on p38 MAPK activation

(2008) Yi-Qun Yao et al.   CANCER LETTERS