Design, synthesis and antitumor efficacy evaluation of a series of novel β-elemene-based macrocycles

Second generation β-elemene nitric oxide derivatives with reasonable linkers: potential hybrids against malignant brain glioma

(2022) Renren Bai et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Anti-Tumor Drug Discovery Based on Natural Product β-Elemene: Anti-Tumor Mechanisms and Structural Modification

(2021) Ziqiang Bai et al.   MOLECULES

Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review

(2021) Tiantian Tan et al.   MOLECULES

Active targeting of orthotopic glioma using biomimetic liposomes co-loaded elemene and cabazitaxel modified by transferritin

(2021) Jie Li et al.   JOURNAL OF NANOBIOTECHNOLOGY

β-elemene suppresses Warburg effect in NCI-H1650 non-small-cell lung cancer cells by regulating the miR-301a-3p/AMPKα axis

(2020) Lin Li et al.   BIOSCIENCE REPORTS

A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation

(2020) Lu Chen et al.   Nature Communications

β-Elemene derivatives produced from SeO 2 -mediated oxidation reaction

(2020) Xingrui He et al.   Royal Society Open Science

Structure-Based Macrocycle Design in Small-Molecule Drug Discovery and Simple Metrics To Identify Opportunities for Macrocyclization of Small-Molecule Ligands

(2019) Maxwell D. Cummings et al.   JOURNAL OF MEDICINAL CHEMISTRY

Strategies for the Diversity-Oriented Synthesis of Macrocycles

(2019) Kim T. Mortensen et al.   CHEMICAL REVIEWS

β-elemene against Burkitt’s lymphoma via activation of PUMA mediated apoptotic pathway

(2018) Tonglin Hu et al.   BIOMEDICINE & PHARMACOTHERAPY

Synthesis and antitumor activity of epothilone B

(2018) Hao Cheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy

(2018) Bingtao Zhai et al.   International Journal of Nanomedicine

Discovery of novel antitumor nitric oxide-donating β -elemene hybrids through inhibiting the PI3K/Akt pathway

(2017) Jichao Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antioxidant Properties of Novel Dimers Derived from Natural β-Elemene through Inhibiting H2O2-Induced Apoptosis

(2017) Jichao Chen et al.   ACS Medicinal Chemistry Letters

Chinese herbal medicine Xiaoji decoction inhibited growth of lung cancer cells through AMPKα-mediated inhibition of Sp1 and DNA methyltransferase 1

(2016) ShunYu Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

�-Elemene Reverses Chemoresistance of Breast Cancer via Regulating MDR-Related MicroRNA Expression

(2014) Jun Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?

(2013) Fabrizio Giordanetto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sensitization of lung cancer cells to cisplatin by β-elemene is mediated through blockade of cell cycle progression: antitumor efficacies of β-elemene and its synthetic analogs

(2013) Q. Quentin Li et al.   MEDICAL ONCOLOGY

Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

(2012) Maxwell D. Cummings et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Macrocycles in new drug discovery

(2012) Jamie Mallinson et al.   Future Medicinal Chemistry

Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry

(2011) Minoru Ishikawa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery

(2011) Eric Marsault et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comparison of diffusion coefficients for matched pairs of macrocyclic and linear molecules over a drug-like molecular weight range

(2011) Andrew R. Bogdan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

β-Elemene Piperazine Derivatives Induce Apoptosis in Human Leukemia Cells through Downregulation of c-FLIP and Generation of ROS

(2011) Zhiying Yu et al.   PLoS One

Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space

(2011) Alexander Alex et al.   MedChemComm

FDA Approval Summary: Temsirolimus as Treatment for Advanced Renal Cell Carcinoma

(2010) V. E. Kwitkowski et al.   ONCOLOGIST

Ixabepilone: A novel microtubule-stabilizing agent for the treatment of metastatic breast cancer

(2008) S. Goodin   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY