Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads

Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel KV1.3: Role of Conformational Dynamics

(2023) Karoline Sanches et al.   Journal of Chemical Information and Modeling

Peripheral Administration of the Kv1.3-Blocking Peptide HsTX1[R14A] Improves Cognitive Performance in Senescence Accelerated SAMP8 Mice

(2023) Yijun Pan et al.   Neurotherapeutics

Kv1.3 blockade by ShK186 modulates CD4+ effector memory T-cell activity of patients with granulomatosis with polyangiitis

(2023) Lucas L Lintermans et al.   RHEUMATOLOGY

Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug

(2022) Anu Tyagi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function

(2022) Serap Erdogmus et al.   Nature Communications

Structural basis for C-type inactivation in a Shaker family voltage-gated K + channel

(2022) Ravikumar Reddi et al.   Science Advances

Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma

(2022) Stephanie Kadow et al.   Cancers

Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators

(2022) Purushotham Selvakumar et al.   Nature Communications

Mechanisms Underlying C-type Inactivation in Kv Channels: Lessons From Structures of Human Kv1.3 and Fly Shaker-IR Channels

(2022) Seow Theng Ong et al.   Frontiers in Pharmacology

Mutations within the selectivity filter reveal that Kv1 channels have distinct propensities to slow inactivate

(2022) Xiaosa Wu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Blockade of Kv1.3 Potassium Channel Inhibits Microglia-Mediated Neuroinflammation in Epilepsy

(2022) Xinyi Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

UniProt: the Universal Protein Knowledgebase in 2023

(2022) et al.   NUCLEIC ACIDS RESEARCH

Unique molecular characteristics and microglial origin of Kv1.3 channel–positive brain myeloid cells in Alzheimer’s disease

(2021) Supriya Ramesha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of K+ Conductance by a Hydrogen Bond in Kv2.1, Kv2.2, and Kv1.2 Channels

(2021) Yuchen Zhang et al.   Membranes

The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation

(2021) Roland Immler et al.   CARDIOVASCULAR RESEARCH

Suppressing Kv1.3 Ion Channel Activity with a Novel Small Molecule Inhibitor Ameliorates Inflammation in a Humanized Mouse Model of Ulcerative Colitis

(2021) Anna-Lena Unterweger et al.   Journal of Crohns & Colitis

Structures of wild-type and H451N mutant human lymphocyte potassium channel KV1.3

(2021) Sanling Liu et al.   Cell Discovery

Blockade of Microglial Kv1.3 Potassium Channels by the Peptide HsTX1[R14A] Attenuates Lipopolysaccharide-mediated Neuroinflammation

(2021) Joseph A. Nicolazzo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Conformational dynamics in peptide toxins: Implications for receptor interactions and molecular design

(2021) Karoline Sanches et al.   TOXICON

The potassium channel Kv1.3 as a therapeutic target for immunocytoprotection after reperfusion

(2021) Yi‐Je Chen et al.   Annals of Clinical and Translational Neurology

Tethered peptide neurotoxins display two blocking mechanisms in the K+ channel pore as do their untethered analogs

(2020) Ruiming Zhao et al.   Science Advances

The voltage-gated potassium channel KV1.3 as a therapeutic target for venom-derived peptides

(2020) Gabor Tajti et al.   BIOCHEMICAL PHARMACOLOGY

Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease

(2020) Souvarish Sarkar et al.   JOURNAL OF CLINICAL INVESTIGATION

Antibodies and venom peptides: new modalities for ion channels

(2019) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Mapping the chemical and sequence space of the ShKT superfamily

(2019) Thomas Shafee et al.   TOXICON

PAP-1 ameliorates DSS-induced colitis with involvement of NLRP3 inflammasome pathway

(2019) Yongyu Mei et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Conformational exchange in the potassium channel blocker ShK

(2019) Naoto Iwakawa et al.   Scientific Reports

Modulating ion channel function with antibodies and nanobodies

(2018) Catelijne Stortelers et al.   CURRENT OPINION IN IMMUNOLOGY

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

(2018) Srikant Rangaraju et al.   Molecular Neurodegeneration

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

(2017) Eugene Y. Chiang et al.   Nature Communications

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

(2017) Martin Vaeth et al.   Nature Communications

Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis

(2017) Judith Land et al.   Frontiers in Immunology

T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers

(2017) Wai-Ping Fung-Leung et al.   PLoS One

Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial

(2017) Eric J. Tarcha et al.   PLoS One

Differential Kv1.3, KCa3.1, and Kir2.1 expression in “classically” and “alternatively” activated microglia

(2016) Hai M. Nguyen et al.   GLIA

Structure of the voltage-gated K+ channel Eag1 reveals an alternative voltage sensing mechanism

(2016) J. R. Whicher et al.   SCIENCE

Atomic mutagenesis in ion channels with engineered stoichiometry

(2016) John D Lueck et al.   eLife

Ion Channels in Innate and Adaptive Immunity

(2015) Stefan Feske et al.   Annual Review of Immunology

N-terminally extended analogues of the K+channel toxin fromStichodactyla helianthusas potent and selective blockers of the voltage-gated potassium channel Kv1.3

(2015) Shih C. Chang et al.   FEBS Journal

Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3-Independent T Cells with Suppressive Properties

(2015) Inna V. Grishkan et al.   JOURNAL OF IMMUNOLOGY

Structural Dynamics of the Potassium Channel Blocker ShK: SRLS Analysis of 15N Relaxation

(2015) Eva Meirovitch et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK

(2015) Michael Pennington et al.   Marine Drugs

Conformational Flexibility in the Binding Surface of the Potassium Channel Blocker ShK

(2014) Inbal Sher et al.   CHEMBIOCHEM

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases

(2014) Sandeep Chhabra et al.   FASEB JOURNAL

Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis – Xenograft model

(2014) Smriti Kundu-Raychaudhuri et al.   JOURNAL OF AUTOIMMUNITY

CD4+ and CD8+ T cell–dependent antiviral immunity requires STIM1 and STIM2

(2014) Patrick J. Shaw et al.   JOURNAL OF CLINICAL INVESTIGATION

A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

(2014) M. Harunur Rashid et al.   Scientific Reports

Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking

(2013) Charles A. Galea et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Intracellular Trafficking of the KV1.3 Potassium Channel Is Regulated by the Prodomain of a Matrix Metalloprotease

(2013) Hai M. Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-type inactivation of voltage-gated K+channels: Pore constriction or dilation?

(2013) Toshinori Hoshi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels

(2013) Stephan A Pless et al.   eLife

Kv1.3 Deletion Biases T Cells toward an Immunoregulatory Phenotype and Renders Mice Resistant to Autoimmune Encephalomyelitis

(2012) A. R. Gocke et al.   JOURNAL OF IMMUNOLOGY

Affinity and Selectivity of ShK Toxin for the Kv1 Potassium Channels from Free Energy Simulations

(2012) M. Harunur Rashid et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

(2011) Victor Chi et al.   TOXICON

The HADDOCK web server for data-driven biomolecular docking

(2010) Sjoerd J de Vries et al.   Nature Protocols

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

Potassium Channel Modulation by a Toxin Domain in Matrix Metalloprotease 23

(2009) Srikant Rangaraju et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering a Stable and Selective Peptide Blocker of the Kv1.3 Channel in T Lymphocytes

(2009) M. W. Pennington et al.   MOLECULAR PHARMACOLOGY

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

(2008) Masatsugu Oh-hora et al.   NATURE IMMUNOLOGY

The Molecular Mechanism of Toxin-Induced Conformational Changes in a Potassium Channel: Relation to C-Type Inactivation

(2008) Ulrich Zachariae et al.   STRUCTURE