Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses

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Androgen receptor activity in T cells limits checkpoint blockade efficacy

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Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity

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Pituitary hormone α-MSH promotes tumor-induced myelopoiesis and immunosuppression

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The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes

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Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer

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PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells

(2022) Laura Codarri Deak et al.   NATURE

SUSD2 suppresses CD8+ T cell antitumor immunity by targeting IL-2 receptor signaling

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PPARγ-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity

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Dietary fructose improves intestinal cell survival and nutrient absorption

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Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory

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The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses

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“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis

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Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1

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DNA methylation during human adipogenesis and the impact of fructose

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High-fructose corn syrup enhances intestinal tumor growth in mice

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CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

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Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells

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Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance

(2019) Dayana B. Rivadeneira et al.   IMMUNITY

STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth

(2019) Chunyan Zhang et al.   Cell Metabolism

Fast, sensitive and accurate integration of single-cell data with Harmony

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Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis

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Leptin and brain–adipose crosstalks

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Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

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Leptin in the interplay of inflammation, metabolism and immune system disorders

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Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity

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Leptin Receptor Signaling in T Cells Is Required for Th17 Differentiation

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HISAT: a fast spliced aligner with low memory requirements

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The future of immune checkpoint therapy

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ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

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Leptin Metabolically Licenses T Cells for Activation To Link Nutrition and Immunity

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Fructose consumption and cancer

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