Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

(2020) Asier González et al.   Cell Metabolism

Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

(2019) Mengqi Li et al.   Cell Metabolism

Isomer activation controls stereospecificity of class I fructose-1,6-bisphosphate aldolases

(2017) Paul W. Heron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

(2017) Chen-Song Zhang et al.   NATURE

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

(2014) Chen-Song Zhang et al.   Cell Metabolism

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

(2012) Alejo Efeyan et al.   NATURE

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Glycolytic Flux Signals to mTOR through Glyceraldehyde-3-Phosphate Dehydrogenase-Mediated Regulation of Rheb

(2009) M. N. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE