Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease

Circadian clocks, cognition, and Alzheimer’s disease: synaptic mechanisms, signaling effectors, and chronotherapeutics

(2022) Kari R. Hoyt et al.   Molecular Neurodegeneration

Hyperexcitable arousal circuits drive sleep instability during aging

(2022) Shi-Bin Li et al.   SCIENCE

Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

(2022) Victoria Acosta-Rodríguez et al.   SCIENCE

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

(2022) Dan Xia et al.   Molecular Neurodegeneration

Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update

(2021) Karim Fifel et al.   Frontiers in Neuroscience

Communicating clocks shape circadian homeostasis

(2021) Kevin B. Koronowski et al.   SCIENCE

Heightened hippocampal β-adrenergic receptor function drives synaptic potentiation and supports learning and memory in the TgF344-AD rat model during prodromal Alzheimer’s disease

(2021) Anthoni M. Goodman et al.   JOURNAL OF NEUROSCIENCE

The Molecular Clock and Neurodegenerative Disease: A Stressful Time

(2021) Bethany Carter et al.   Frontiers in Molecular Biosciences

Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020–2060)

(2021) Kumar B. Rajan et al.   Alzheimers & Dementia

Time-restricted eating for the prevention and management of metabolic diseases

(2021) Emily N Manoogian et al.   ENDOCRINE REVIEWS

Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors

(2021) Karen R. Mifsud et al.   Nature Communications

The role of orexin in Alzheimer disease: From sleep-wake disturbance to therapeutic target

(2021) Fan Gao et al.   NEUROSCIENCE LETTERS

BMI1 is associated with CSF amyloid-β and rates of cognitive decline in Alzheimer’s disease

(2021) Jun Pyo Kim et al.   Alzheimers Research & Therapy

Multi-Modal Regulation of Circadian Physiology by Interactive Features of Biological Clocks

(2021) Yool Lee et al.   Biology-Basel

The Novel Role of PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer’s Disease and Other Neurodegenerative Disorders

(2020) Sylwia Wójtowicz et al.   NEUROCHEMICAL RESEARCH

Total Aβ42/Aβ40 ratio in plasma predicts amyloid-PET status, independent of clinical AD diagnosis

(2020) James D. Doecke et al.   NEUROLOGY

Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

(2020) Ying-Wooi Wan et al.   Cell Reports

Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer’s Disease

(2020) Jeremiah K. H. Lim et al.   Frontiers in Neuroscience

The circadian dynamics of the hippocampal transcriptome and proteome is altered in experimental temporal lobe epilepsy

(2020) K. J. Debski et al.   Science Advances

Preferred Endocytosis of Amyloid Precursor Protein from Cholesterol-Enriched Lipid Raft Microdomains

(2020) Yoon Young Cho et al.   MOLECULES

Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans

(2019) Humaira Jamshed et al.   Nutrients

Histone demethylase PHF2 activates CREB and promotes memory consolidation

(2019) Hye‐Jin Kim et al.   EMBO REPORTS

Periodic dietary restriction ameliorates amyloid pathology and cognitive impairment in PDAPP-J20 mice: Potential implication of glial autophagy

(2019) Amal Gregosa et al.   NEUROBIOLOGY OF DISEASE

Bidirectional relationship between sleep and Alzheimer’s disease: role of amyloid, tau, and other factors

(2019) Chanung Wang et al.   NEUROPSYCHOPHARMACOLOGY

Roles of Neuropeptide Y in Neurodegenerative and Neuroimmune Diseases

(2019) Chunrong Li et al.   Frontiers in Neuroscience

A longitudinal assessment of retinal function and structure in the APP/PS1 transgenic mouse model of Alzheimer’s disease

(2019) Dana Georgevsky et al.   Translational Neurodegeneration

Sleep architecture changes in the APP23 mouse model manifest at onset of cognitive deficits

(2019) Jan Van Erum et al.   BEHAVIOURAL BRAIN RESEARCH

Decay in Retinoic Acid Signaling in Varied Models of Alzheimer’s Disease and In-Vitro Test of Novel Retinoic Acid Receptor Ligands (RAR-Ms) to Regulate Protective Genes

(2019) Thabat Khatib et al.   JOURNAL OF ALZHEIMERS DISEASE

Ketone bodies as epigenetic modifiers

(2018) Hai-Bin Ruan et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Modeling Late-Onset Sporadic Alzheimer’s Disease through BMI1 Deficiency

(2018) Anthony Flamier et al.   Cell Reports

Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease

(2018) Erik S. Musiek et al.   JAMA Neurology

Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington’s Disease

(2018) Daniel S. Whittaker et al.   JOURNAL OF BIOLOGICAL RHYTHMS

A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine

(2018) Marc D. Ruben et al.   Science Translational Medicine

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

(2018) Janine L. Kwapis et al.   Nature Communications

GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity

(2017) Rachel C. Besing et al.   HIPPOCAMPUS

Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting

(2017) Stephen D. Anton et al.   Obesity

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

(2017) Lindsay M. Lueptow   Jove-Journal of Visualized Experiments

Retinal Ganglion Cells and Circadian Rhythms in Alzheimer’s Disease, Parkinson’s Disease, and Beyond

(2017) Chiara La Morgia et al.   Frontiers in Neurology

Plasma β-amyloid in Alzheimer’s disease and vascular disease

(2016) Shorena Janelidze et al.   Scientific Reports

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Entrainment of circadian clocks in mammals by arousal and food

(2015) Ralph E Mistlberger et al.   Essays in Biochemistry

Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges

(2014) Amandine Chaix et al.   Cell Metabolism

Connections between sleep and cognition in older adults

(2014) Kristine Yaffe et al.   LANCET NEUROLOGY

PPARs Integrate the Mammalian Clock and Energy Metabolism

(2014) Lihong Chen et al.   PPAR Research

Chronobiology and nutrition

(2013) Y. Tahara et al.   NEUROSCIENCE

The Q175 Mouse Model of Huntington’s Disease Shows Gene Dosage- and Age-Related Decline in Circadian Rhythms of Activity and Sleep

(2013) Dawn H. Loh et al.   PLoS One

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

Rapid Assessment of Sleep-Wake Behavior in Mice

(2012) Simon P. Fisher et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Bmi1 Is Down-Regulated in the Aging Brain and Displays Antioxidant and Protective Activities in Neurons

(2012) Mohamed Abdouh et al.   PLoS One

Alzheimer's Disease-Linked Mutations in Presenilin-1 Result in a Drastic Loss of Activity in Purified γ-Secretase Complexes

(2012) Matthias Cacquevel et al.   PLoS One

Characterization of a Drosophila Alzheimer's Disease Model: Pharmacological Rescue of Cognitive Defects

(2011) Ranjita Chakraborty et al.   PLoS One

Interaction between hypothalamic dorsomedial nucleus and the suprachiasmatic nucleus determines intensity of food anticipatory behavior

(2011) G. Acosta-Galvan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition

(2011) Carlo Condello et al.   Scientific Reports

Suprachiasmatic Nucleus: Cell Autonomy and Network Properties

(2010) David K. Welsh et al.   Annual Review of Physiology

The Transcriptional Repressor ID2 Can Interact with the Canonical Clock Components CLOCK and BMAL1 and Mediate Inhibitory Effects onmPer1Expression

(2010) Sarah M. Ward et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

Bidirectional interactions between the circadian and reward systems: is restricted food access a unique zeitgeber?

(2009) Ian C. Webb et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Regulation of Clock-Controlled Genes in Mammals

(2009) Katarzyna Bozek et al.   PLoS One

Dynamics of A  Turnover and Deposition in Different  -Amyloid Precursor Protein Transgenic Mouse Models Following  -Secretase Inhibition

(2008) D. Abramowski et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS