Review
Biochemistry & Molecular Biology
Evrim Yildirim, Rachel Curtis, Dae-Sung Hwangbo
Summary: Biological clocks are essential mechanisms that synchronize physiological and behavioral processes with external cues to ensure organisms' fitness and survival. While the central clock in the brain drives daily activity rhythms, peripheral tissues have their own clock systems generating metabolic and physiological rhythms. The fruit fly Drosophila melanogaster has been a widely studied model organism for investigating the mechanism and functions of circadian clocks.
Article
Endocrinology & Metabolism
Gabriella M. Marino, Deanna M. Arble
Summary: Sleep and circadian disruption are linked to a higher risk of metabolic disease. Researchers propose that targeting groups of cells with functional relationships can provide a better understanding of the consequences of sleep and circadian disruption, especially for metabolic outcomes that involve multiple sites of action.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
Peter S. Johnstone, Maite Ogueta, Olga Akay, Inan Top, Sheyum Syed, Ralf Stanewsky, Deniz Top
Summary: This study developed a new method, called Locally Activatable BioLuminescence (LABL), to directly measure the transcriptional oscillation of specific neuronal and peripheral clocks in intact Drosophila. The results showed that loss of the receptor for the circadian neurotransmitter PDF only disrupted locomotor activity but not all tissue-specific circadian clocks.
Editorial Material
Cell Biology
Zhihui Zhang, Guanghou Shui, Min-Dian Li
Summary: Meal timing can reset cellular circadian clocks in the body, with clocks in different tissues being reset to varying degrees by feeding rhythms, and modulated by the central clock and the liver clock. Tissue-specific regulation and intercellular signaling play essential roles in clock synchronization.
TRENDS IN CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Chi-Hui Tsao, Jonathan Flint, Guo-Jen Huang
Summary: This study compares the effects of conducting behavioral tests at different diurnal phases on mouse behavior. The results show that during the active phase, mice exhibit higher cutaneous sensitivity, better long-term contextual memory, and a greater active avoidance escape response. There were no significant sex effects observed in these tests.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Jieyu Wu, Xu Jing, Qiqiao Du, Xiaoting Sun, Kristian Holgersson, Juan Gao, Xingkang He, Kayoko Hosaka, Chen Zhao, Wei Tao, Garret A. FitzGerald, Yunlong Yang, Lasse D. Jensen, Yihai Cao
Summary: This study demonstrates that disruption of the circadian rhythm by genetic deletion of the Bmal1 gene in mice enhances fibrosis in tumors, leading to increased tumor growth and metastatic potential. The deletion of Bmal1 results in decreased expression of its target gene PAI-1, which leads to activation of plasmin and subsequent fibrosis and transition of cancer-associated fibroblasts. Inhibiting the TGF-beta signaling pathway effectively reduces the metastatic potential of several types of cancer. These findings provide novel insights into the role of the circadian clock in tumor growth and metastasis, suggesting that normalization of the circadian rhythm could be a potential therapeutic strategy for cancer.
Review
Biochemistry & Molecular Biology
Leonardo Vinicius Monteiro de Assis, Henrik Oster
Summary: The circadian clock plays a crucial role in maintaining systemic homeostasis by synchronizing with environmental challenges and biological processes. Communication between central and peripheral clocks is essential, and the modulation of metabolic organs by the circadian clock is a key aspect of its function. Recent studies on communication between peripheral tissues provide new insights into circadian organization.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Genetics & Heredity
Yuntao Lu, Bing Liu, Junjie Ma, Shuo Yang, Ju Huang
Summary: Short-term sleep deprivation causes changes in the circadian gene expression of approximately 3,000 genes in the mouse lung, particularly in genes associated with metabolism and signaling pathways regulating protein phosphorylation. The positive correlation between mean expression and amplitude of cycling genes is maintained under sleep deprivation conditions, supporting the energetic cost optimization model of circadian gene expression.
FRONTIERS IN GENETICS
(2021)
Article
Nutrition & Dietetics
Louis Desmet, Theo Thijs, Rosalie Mas, Kristin Verbeke, Inge Depoortere
Summary: The study found that time-restricted feeding can restore the rhythmicity of clock genes, regulate ghrelin levels, prevent weight gain, and maintain body homeostasis during chronic jetlag.
Article
Multidisciplinary Sciences
Shirley L. Zhang, Nicholas F. Lahens, Zhifeng Yue, Denice M. Arnold, Peter P. Pakstis, Jessica E. Schwarz, Amita Sehgal
Summary: The blood-brain barrier is critical for neural function, and this study shows that efflux of xenobiotics through the BBB follows a circadian rhythm in mice and human cells. Interestingly, limited circadian regulation of transcription was detected in brain endothelial cells, with no evident oscillations in efflux transporters. The molecular clock drives cycling of intracellular magnesium through transcriptional regulation, contributing to the rhythm in efflux.
NATURE COMMUNICATIONS
(2021)
Review
Cardiac & Cardiovascular Systems
Nadim El Jamal, Ronan Lordan, Sarah L. Teegarden, Tilo Grosser, Garret FitzGerald
Summary: Cardiac physiology is regulated by autonomous molecular clocks and the suprachiasmatic nucleus, exhibiting diurnal rhythms. Disrupting molecular clocks can lead to heart failure, and the time of day can condition myocardial response to injury. Human studies support the involvement of molecular clocks and circadian rhythms in the pathogenesis of heart failure. Certain circadian rhythms are maintained in heart failure patients, which can guide optimal timing of therapy. Manipulation of circadian rhythms and molecular clocks show promise in the prevention and treatment of heart failure.
CIRCULATION RESEARCH
(2023)
Review
Biology
Mohammad Mofatteh, Fabio Echegaray-Iturra, Andrew Alamban, Francesco Dalla Ricca, Anand Bakshi, Mustafa G. Aydogan
Summary: This review explores how cells perceive and use temporal information to regulate their internal processes. The emerging concept of 'autonomous clocks' is introduced, which can function independently but also be influenced by the cell cycle and circadian clock. The authors discuss the roles of these clocks in different scales and complexities, shedding light on their evolutionary significance and potential therapeutic applications.
Review
Physiology
Melissa L. Erickson, Karyn A. Esser, William E. Kraus, Thomas W. Buford, Leanne M. Redman
Summary: Disruption of the skeletal muscle circadian clock leads to a shift towards lipid oxidation and decrease in carbohydrate oxidation at the whole-body level, resulting in metabolic disturbances. Exercise is hypothesized to counter these disturbances by modifying the skeletal muscle clock and restoring optimal substrate balance.
EXERCISE AND SPORT SCIENCES REVIEWS
(2021)
Article
Biology
Mikolaj Mazur, Magdalena Markowska, Magdalena Chadzinska, Lukasz Pijanowski
Summary: This study provides a detailed analysis of the rhythmic expression of key components of the biological clock in common carp. The expression of clock genes, bmal genes, per genes, and cry genes in the brain, pituitary gland, and retina of carp was found to be the highest. The expression pattern of clock and bmal genes aligned with the lights off, while per genes showed a similar phasing with acrophase close to light onset. The expression of cry genes varied depending on the type of tissue and gene subtype.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Review
Neurosciences
Stefano Govoni, Francesca Fagiani, Cristina Lanni, Nicola Allegri
Summary: Assessing biological age and frailty and predicting lifespan and health status is valuable for interventions to alter the pace of aging and frailty. Finding biological markers and clocks helps guide intervention design and establish the relationship between aging and health trajectories.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yool Lee, Sung Kook Chun, Kyungjin Kim
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2015)
Article
Biology
Yool Lee, A. Reum Jang, Lauren J. Francey, Amita Sehgal, John B. Hogenesch
Article
Neurosciences
Robbert Havekes, Alan J. Park, Rosa E. Tolentino, Vibeke M. Bruinenberg, Jennifer C. Tudor, Yool Lee, Rolf T. Hansen, Leonardo A. Guercio, Edward Linton, Susana R. Neves-Zaph, Peter Meerlo, George S. Baillie, Miles D. Houslay, Ted Abel
JOURNAL OF NEUROSCIENCE
(2016)
Article
Cell Biology
Lei Bai, Yool Lee, Cynthia T. Hsu, Julie A. Williams, Daniel Cavanaugh, Xiangzhong Zheng, Carly Stein, Paula Haynes, Han Wang, David H. Gutmann, Amita Sehgal
Article
Biochemistry & Molecular Biology
Ron C. Anafi, Yool Lee, Trey K. Sato, Anand Venkataraman, Chidambaram Ramanathan, Ibrahim H. Kavakli, Michael E. Hughes, Julie E. Baggs, Jacqueline Growe, Andrew C. Liu, Junhyong Kim, John B. Hogenesch
Article
Biochemistry & Molecular Biology
Yool Lee, Nicholas F. Lahens, Shirley Zhang, Joseph Bedont, Jeffrey M. Field, Amita Sehgal
Article
Multidisciplinary Sciences
Yool Lee, Yang Shen, Lauren J. Francey, Chidambaram Ramanathan, Amita Sehgal, Andrew C. Liu, John B. Hogenesch
SCIENTIFIC REPORTS
(2019)
Article
Biology
Rachael A. Muck, Hans P. A. Van Dongen, Michelle A. Schmidt, Jonathan P. Wisor, Matthew E. Layton, Dawn M. DePriest, Kimberly A. Honn, Brieann C. Satterfield
CHRONOBIOLOGY INTERNATIONAL
(2020)
Article
Multidisciplinary Sciences
Yool Lee, Shi Yi Fong, Joy Shon, Shirley L. Zhang, Rebekah Brooks, Nicholas F. Lahens, Dechun Chen, Chi Van Dang, Jeffrey M. Field, Amita Sehgal
Summary: Research has shown that circadian rhythms influence the activity of known antitumor agents, with the rhythmic action of HSP90 inhibitors mediated by specific isoforms of HSP90. Clock mutants affect the cell cycle, and pharmacological inhibition of the cell cycle eliminates rhythmic drug effects.
Article
Clinical Neurology
Jonathan P. Wisor, Nils Henrik Holmedahl, Ingvild West Saxvig, Odd-Magne Fjeldstad, Eddie Weitzberg, Janne Gronli, Harald Kare Engan
Summary: The study found that nitrate supplementation with beetroot juice can improve sleep quality in COPD patients, reduce atypical transitions, and increase oxygen saturation levels.
NATURE AND SCIENCE OF SLEEP
(2021)
Review
Biology
Yool Lee, Jeffrey M. Field, Amita Sehgal
Summary: Circadian clocks play a crucial role in regulating physiological and behavioral rhythms, with studies showing their importance in modulating cellular and organismal responses to physiological cues and medical interventions. Advancements in understanding the molecular and cellular mechanisms of circadian physiology and pathophysiology have opened up new possibilities for targeting circadian rhythms for disease prevention and treatment.
JOURNAL OF BIOLOGICAL RHYTHMS
(2021)
Review
Biochemistry & Molecular Biology
Yool Lee
Summary: Circadian clocks play a crucial role in optimizing physiological functions and behaviors in response to daily environmental changes, but dysregulation can increase susceptibility to diseases, especially cancer. Recent studies have highlighted the dynamic crosstalk between circadian clocks and cancer pathways, offering new insights into potential therapeutic strategies for cancer treatment.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Yool Lee, Alfian Shan Tanggono
Summary: This article reviews recent discoveries regarding the impact of circadian rhythms on cancer stem cell characteristics. Disruptions in circadian rhythms can lead to pathological changes in cancer, and cancer stem cells are responsible for tumor recurrence and metastasis. These cells are associated with the epithelial-mesenchymal transition, which gives them enhanced motility and invasion abilities. Emerging studies suggest that the circadian clock plays a crucial role in maintaining CSC/EMT characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)