Preferred Endocytosis of Amyloid Precursor Protein from Cholesterol-Enriched Lipid Raft Microdomains

High-Cholesterol Diet Decreases the Level of Phosphatidylinositol 4,5-Bisphosphate by Enhancing the Expression of Phospholipase C (PLCβ1) in Rat Brain

(2020) Yoon Sun Chun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A practical application of generative adversarial networks for RNA-seq analysis to predict the molecular progress of Alzheimer's disease

(2020) Jinhee Park et al.   PLoS Computational Biology

The mystery of membrane organization: composition, regulation and roles of lipid rafts

(2017) Erdinc Sezgin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

APP Function and Lipids: A Bidirectional Link

(2017) Marcus O. W. Grimm et al.   Frontiers in Molecular Neuroscience

Alterations in Brain Cholesterol Metabolism in the APPSLxPS1mut mouse, a Model for Alzheimer's Disease

(2017) Tim Vanmierlo et al.   JOURNAL OF ALZHEIMERS DISEASE

Cholesterol regulates multiple forms of vesicle endocytosis at a mammalian central synapse

(2015) Hai-Yuan Yue et al.   JOURNAL OF NEUROCHEMISTRY

Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer’s disease early phenotypes

(2015) Catherine Marquer et al.   Molecular Neurodegeneration

Role of cholesterol metabolism in the pathogenesis of Alzheimerʼs disease

(2014) Bernadette Allinquant et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Altered lipid composition in cortical lipid rafts occurs at early stages of sporadic Alzheimer's disease and facilitates APP/BACE1 interactions

(2014) Noemí Fabelo et al.   NEUROBIOLOGY OF AGING

Competition Between Homodimerization and Cholesterol Binding to the C99 Domain of the Amyloid Precursor Protein

(2013) Yuanli Song et al.   BIOCHEMISTRY

Suppression of amyloid-β production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking

(2013) Yasuomi Urano et al.   FASEB JOURNAL

Modulation of Lipid Kinase PI4KIIα Activity and Lipid Raft Association of Presenilin 1 Underlies γ-Secretase Inhibition by Ginsenoside (20S)-Rg3

(2013) Min Suk Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts

(2013) R. Bhattacharyya et al.   JOURNAL OF NEUROSCIENCE

Cross-talk of membrane lipids and Alzheimer-related proteins

(2013) Jochen Walter et al.   Molecular Neurodegeneration

Endocytosis of Gene Delivery Vectors: From Clathrin-dependent to Lipid Raft-mediated Endocytosis

(2013) Ayman El-Sayed et al.   MOLECULAR THERAPY

Cholesterol as a co-solvent and a ligand for membrane proteins

(2013) Yuanli Song et al.   PROTEIN SCIENCE

Anticancer mechanisms and clinical application of alkylphospholipids

(2012) Wim J. van Blitterswijk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Reciprocal regulation of cholesterol and beta amyloid at the subcellular level in Alzheimer’s disease

(2012) Elena Posse de Chaves   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis

(2012) M. Maulik et al.   MOLECULAR NEUROBIOLOGY

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

(2012) P. J. Barrett et al.   SCIENCE

Lipid Rafts and Alzheimer’s Disease: Protein-Lipid Interactions and Perturbation of Signaling

(2012) David A. Hicks et al.   Frontiers in Physiology

A practical guide to evaluating colocalization in biological microscopy

(2011) Kenneth W. Dunn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Endogenous amyloidogenesis in long-term rat hippocampal cell cultures

(2011) Sarah J Bertrand et al.   BMC NEUROSCIENCE

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis

(2011) Catherine Marquer et al.   FASEB JOURNAL

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid–Alzheimer's disease relationships?

(2010) Andrew J. Beel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Intracellular cholesterol homeostasis and amyloid precursor protein processing

(2010) Mark P. Burns et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Clathrin-dependent APP endocytosis and Aβ secretion are highly sensitive to the level of plasma membrane cholesterol

(2010) Jack-Christophe Cossec et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Membrane rafts in Alzheimer's disease beta-amyloid production

(2010) Kulandaivelu S. Vetrivel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Searching for the role of membrane sphingolipids in selectivity of antitumor ether lipid–edelfosine

(2010) Katarzyna Hąc-Wydro et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

γ-secretases: from cell biology to therapeutic strategies

(2010) Bruno A Bergmans et al.   LANCET NEUROLOGY

Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids

(2010) José M Jiménez-López et al.   Lipids in Health and Disease

Lipid raft-targeted therapy in multiple myeloma

(2010) F Mollinedo et al.   ONCOGENE

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Structural Studies of the Transmembrane C-Terminal Domain of the Amyloid Precursor Protein (APP): Does APP Function as a Cholesterol Sensor?†‡

(2008) Andrew J. Beel et al.   BIOCHEMISTRY

Active γ-secretase is localized to detergent-resistant membranes in human brain

(2008) Ji-Yeun Hur et al.   FEBS Journal

Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment

(2008) Pamela Osenkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flotillin-Dependent Clustering of the Amyloid Precursor Protein Regulates Its Endocytosis and Amyloidogenic Processing in Neurons

(2008) A. Schneider et al.   JOURNAL OF NEUROSCIENCE

Edelfosine Is Incorporated into Rafts and Alters Their Organization

(2008) Alessio Ausili et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

(2007) Huaqi Xiong et al.   NEUROBIOLOGY OF DISEASE