Article
Multidisciplinary Sciences
Gyutae Kim, Nara Shin, Kyu-Sung Kim
Summary: Electrical stimulation can relieve Parkinsonian symptoms by modulating neural network activity. Galvanic vestibular stimulation (GVS) affects neural activity for motor control. This study investigated the underlying mechanism of GVS by analyzing its effects on the vestibular nucleus (VN). The results showed that GVS down-regulated the increased glutamate receptors in PD models, mainly through NMDA receptors in VN.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Rachel E. Gunraj, Changjun Yang, Lei Liu, Jonathan Larochelle, Eduardo Candelario-Jalil
Summary: Adropin, a highly conserved secreted peptide encoded by the Enho gene, plays a crucial role in maintaining lipid homeostasis and regulating insulin sensitivity. It also participates in pathophysiological processes of CNS diseases, providing protective effects in stroke, heart disease, aging, and other diseases. Recent findings suggest its critical role in regulating endothelial cells and maintaining blood-brain barrier integrity.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Nicholas D. Schiff, Emery N. Brown
Summary: The slow recovery of consciousness in COVID-19 patients may be related to the neurometabolic state and latent neuroprotective mechanisms in the brain.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Xiaofan Gao, Bo Wang, Yibao Huang, Meng Wu, Yuting Li, Yinuo Li, Xiaoran Zhu, Mingfu Wu
Summary: The ovary, as a reproductive endocrine organ in women, plays a significant role in the aging process, leading to menopause, decreased fertility, and long-term health risks. Oxidative stress is closely associated with aging metabolic processes and affects both physiological and pathological ovarian aging. The Nrf2 pathway is crucial in regulating the antioxidant response, and therapeutic strategies aimed at modulating this pathway have been identified to ameliorate ovarian aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Mohamed S. Mady, Heba E. Elsayed, Elsayed K. El-Sayed, Ahmed A. Hussein, Hassan Y. Ebrahim, Fatma A. Moharram
Summary: This study validates the strong antioxidant, analgesic, anti-skin aging, and antidiarrheal activities of C. sabulatus leaves for the first time, with a wide array of bioactive polyphenolic metabolites identified. Ethnopharmacological resources like C. sabulatus with high levels of polyphenols hold potential for managing various human ailments.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Reham Z. Hamza, Mohammad S. Al-Harbi, Munirah A. Al-Hazaa
Summary: This study found that chitosan nanoparticles (CH-NPs), quercetin (Q), and resveratrol (RV) could reduce oxidative stress and biochemical alterations induced by D-galactose (DG), while enhancing antioxidant capacity in brain and testicular tissues.
Article
Plant Sciences
Tanzina Akter, Md Atikur Rahman, Akhi Moni, Md. Aminul Islam Apu, Atqiya Fariha, Md. Abdul Hannan, Md Jamal Uddin
Summary: This study investigated the therapeutic aspects of Moringa oleifera in kidney diseases, exploring its anti-inflammation and antioxidant properties. The study found that Moringa oleifera can up-regulate antioxidant enzymes and down-regulate inflammatory cytokines in the kidney, suggesting its potential as an effective medicine for human benefits.
Article
Nutrition & Dietetics
Liu-Hong Shen, Lei Fan, Yue Zhang, Yu Shen, Zhe-Tong Su, Guang-Neng Peng, Jun-Liang Deng, Zhi-Jun Zhong, Xiao-Feng Wu, Shu-Min Yu, Sui-Zhong Cao, Xiao-Lan Zong
Summary: The study found that cow placenta extract has strong antioxidant properties, can increase the activity of various enzymes, decrease the content of malondialdehyde, and regulate gene and protein expression in mouse skin to delay skin aging.
Article
Plant Sciences
Chaoran Song, Chae Young Lee, Hwa Pyoung Lee, Mohammad Amjad Hossain, Zhiyun Zhang, Soo-Yong Kim, Minkyung Song, Jong-Hoon Kim, Jae Youl Cho
Summary: This study found that methanol extract from Malus baccata has significant antioxidant capacity and can protect against aging by attenuating UVB and H2O2-induced apoptosis and ROS generation. It also inhibits the expression of MMPs and promotes the synthesis of collagen.
Article
Chemistry, Medicinal
Huan Li, Bingtao Zhai, Jing Sun, Yu Fan, Junbo Zou, Jiangxue Cheng, Xiaofei Zhang, Yajun Shi, Dongyan Guo
Summary: The study demonstrated that Aralia taibaiensis total saponins (TSAT) have significant antioxidant, anti-aging, and organ-protective effects in D-galactose induced aging rats. TSAT showed scavenging effects on various radicals in vitro and effectively improved D-galactose induced organ injury in aging rats, enhancing antioxidant enzyme levels while reducing oxidative stress markers.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Cell Biology
Yajuan Li, Wenxu Zhang, Anthony A. Fung, Lingyan Shi
Summary: This study presents a new optical imaging platform to directly visualize and quantify lipid metabolism in Drosophila fat body regulated by different diets and insulin signaling pathway. The findings reveal the interconnections between lipid metabolism, diets, and aging, providing a better understanding of these processes.
Article
Pharmacology & Pharmacy
Liang Zhang, Yang Yang, Zhanyong Wang
Summary: In this study, response surface technique was used to optimize the extraction of corn silk polysaccharides, resulting in the determination of optimal extraction parameters and demonstrating the strong antioxidant capabilities of CSP. In vivo experiments showed that CSP significantly enhanced antioxidant enzyme activities and reduced malondialdehyde levels in aged mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hao Jin, Z. Hershel Fishman, Mingyu Ye, Li Wang, Charles S. Zuker
Summary: The study reveals the importance of hardwired circuits in the mammalian brain for sweet and bitter responses, which can affect appetitive and aversive behaviors. The brain modulates taste behaviors by controlling these hardwired circuits, with sweet and bitter signals receiving positive and negative feedback in the neural system.
Article
Environmental Sciences
Sushmitha Shankar, Anusha Narayana Murthy, P. Rachitha, Vinay B. Raghavendra, N. Sunayana, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Nagaraj Basavegowda, Kathirvel Brindhadevi, Arivalagan Pugazhendhi
Summary: The study focused on the conjugation of silk sericin protein with magnesium oxide nanoparticles to form SS-MgO-NPs. Various techniques, such as UV, XRD, FTIR, SEM, DLS, and EDX, were used to confirm the formation of SS-MgO-NPs. The SS-MgO-NPs showed promising properties, including antioxidant, antibacterial, anti-biofilm, anti-aging, and anticancer activities. Further in vivo research is necessary to validate the therapeutic applications of SS-MgO-NPs.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yufei Pang, Jingxin Chen, Jianjun Yang, Yanzhong Xue, Hua Gao, Qinghan Gao
Summary: This study investigated the neuroprotective effects of Lycium ruthenicum polyphenols (LRP) against acrylamide (ACR)-induced neurotoxicity in vitro and in vivo. LRP treatment attenuated ACR-induced cytotoxicity in SH-SY5Y cells, activated the Nrf2 pathway, and down-regulated apoptotic proteins. In ACR-induced rats, LRP improved behavioral deficits, activated the Nrf2 pathway, reduced ROS levels, and increased dopamine levels. Therefore, LRP can protect against ACR-induced brain damage.
Article
Developmental Biology
Shufeng Zhou, Anthony Flamier, Mohamed Abdouh, Nicolas Tetreault, Andrea Barabino, Shashi Wadhwa, Gilbert Bernier
Article
Biochemistry & Molecular Biology
Mohamed Abdouh, Roy Hanna, Jida El Hajjar, Anthony Flamier, Gilbert Bernier
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Developmental Biology
Andrea Barabino, Vicky Plamondon, Mohamed Abdouh, Wassim Chatoo, Anthony Flamier, Roy Hanna, Shufeng Zhou, Noboru Motoyama, Marc Hebert, Joelle Lavoie, Gilbert Bernier
Article
Oncology
Dana Hamam, Mohamed Abdouh, Zu-Hua Gao, Vincenzo Arena, Manuel Arena, Goffredo Orazio Arena
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2016)
Article
Oncology
Mohamed Abdouh, Dana Hamam, Zu-Hua Gao, Vincenzo Arena, Manuel Arena, Goffredo Orazio Arena
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2017)
Article
Medicine, Research & Experimental
Goffredo Orazio Arena, Vincenzo Arena, Manuel Arena, Mohamed Abdouh
MEDICAL HYPOTHESES
(2017)
Article
Cell Biology
Anthony Flamier, Jida El Hajjar, James Adjaye, Karl J. Fernandes, Mohamed Abdouh, Gilbert Bernier
Article
Oncology
Mohamed Abdouh, Shufeng Zhou, Vincenzo Arena, Manuel Arena, Anthoula Lazaris, Ronald Onerheim, Peter Metrakos, Goffredo Orazio Arena
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2014)
Article
Multidisciplinary Sciences
Shufeng Zhou, Mohamed Abdouh, Vincenzo Arena, Manuel Arena, Goffredo Orazio Arena
Article
Multidisciplinary Sciences
Jida El Hajjar, Wassim Chatoo, Roy Hanna, Patrick Nkanza, Nicolas Tetreault, Yiu Chung Tse, Tak Pan Wong, Mohamed Abdouh, Gilbert Bernier
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Mohamed Abdouh, Zu-Hua Gao, Vincenzo Arena, Manuel Arena, Miguel N. Burnier, Goffredo Orazio Arena
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Mohamed Abdouh, Matteo Floris, Zu-Hua Gao, Vincenzo Arena, Manuel Arena, Goffredo Orazio Arena
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Thupten Tsering, Alexander Laskaris, Mohamed Abdouh, Prisca Bustamante, Sabrina Parent, Eva Jin, Sarah Tadhg Ferrier, Goffredo Arena, Julia V. Burnier
Article
Ophthalmology
Mohamed Abdouh, Melissa Lu, Yunxi Chen, Alicia N. Goyeneche, Julia Valdemarin Burnier, Miguel N. Burnier
Summary: Age-related macular degeneration (AMD) is a leading cause of blindness in elderly individuals. Exposure to blue light (BL) has been identified as a risk factor for AMD progression. This study aimed to investigate the effects of BL on retinal pigment epithelial (RPE) cells and assess the potential mitigation of these effects by BL-filtering intraocular lenses (IOLs). The findings revealed that BL exposure increased oxidative stress and cell death in RPE cells, which could be reduced by using IOLs that filter out BL and ultraviolet radiation.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Oncology
Anthony Flamier, Mohamed Abdouh, Rimi Hamam, Andrea Barabino, Niraj Patel, Andy Gao, Roy Hanna, Gilbert Bernier
NPJ PRECISION ONCOLOGY
(2020)