Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer

Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment

(2023) Jie Cheng et al.   Cell Metabolism

Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

(2023) Joseph Tintelnot et al.   NATURE

ROS-regulated phosphorylation of ITPKB by CAMK2G drives cisplatin resistance in ovarian cancer

(2022) Jie Li et al.   ONCOGENE

Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer

(2022) Marcello Stanzione et al.   Science Advances

Hallmarks of DNA replication stress

(2022) Sneha Saxena et al.   MOLECULAR CELL

Replication stalling activates SSB for recruitment of DNA damage tolerance factors

(2022) Elizabeth S. Thrall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox controls RecA protein activity via reversible oxidation of its methionine residues

(2021) Camille Henry et al.   eLife

Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis

(2021) Yi-Ping Wang et al.   Cell Metabolism

Moonlighting functions of metabolic enzymes and metabolites in cancer

(2021) Chaoyun Pan et al.   MOLECULAR CELL

REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps

(2021) Angelo Taglialatela et al.   MOLECULAR CELL

Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1

(2021) Chaoyun Pan et al.   Nature Communications

Amino acids in cancer

(2020) Elizabeth L. Lieu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

TRIP13 regulates DNA repair pathway choice through REV7 conformational change

(2020) Connor S. Clairmont et al.   NATURE CELL BIOLOGY

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

(2020) Jin-Tao Li et al.   NATURE CELL BIOLOGY

DGKA provides platinum resistance in ovarian cancer through activation of cJUN-WEE1 signaling

(2020) Jie Li et al.   CLINICAL CANCER RESEARCH

First-Line Management of Advanced High-Grade Serous Ovarian Cancer

(2020) Reem D. Mahmood et al.   Current Oncology Reports

The ubiquitin ligase RFWD3 is required for translesion DNA synthesis

(2020) Irene Gallina et al.   MOLECULAR CELL

Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers

(2019) Jung-Hoon Yoon et al.   CELL

Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance

(2019) Chaoyun Pan et al.   JOURNAL OF CLINICAL INVESTIGATION

A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy

(2019) Jessica L. Wojtaszek et al.   CELL

Dietary methionine influences therapy in mouse cancer models and alters human metabolism

(2019) Xia Gao et al.   NATURE

Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization

(2019) Christiaan F. Labuschagne et al.   Cell Metabolism

New aspects of amino acid metabolism in cancer

(2019) Lisa Vettore et al.   BRITISH JOURNAL OF CANCER

MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

(2018) Lingtao Jin et al.   CANCER CELL

Asparagine bioavailability governs metastasis in a model of breast cancer

(2018) Simon R. V. Knott et al.   NATURE

Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair

(2018) Parker L. Sulkowski et al.   NATURE GENETICS

RNA-splicing factor SART3 regulates translesion DNA synthesis

(2018) Min Huang et al.   NUCLEIC ACIDS RESEARCH

Histidine catabolism is a major determinant of methotrexate sensitivity

(2018) Naama Kanarek et al.   NATURE

Correcting for natural isotope abundance and tracer impurity in MS-, MS/MS- and high-resolution-multiple-tracer-data from stable isotope labeling experiments with IsoCorrectoR

(2018) Paul Heinrich et al.   Scientific Reports

Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy

(2017) Xinjian Li et al.   MOLECULAR CELL

Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN

(2017) Nausica Arnoult et al.   NATURE

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth

(2015) Lingtao Jin et al.   CANCER CELL

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

(2015) Yuhui Jiang et al.   NATURE CELL BIOLOGY

Translesion DNA Synthesis and Mutagenesis in Eukaryotes

(2013) J. E. Sale   Cold Spring Harbor Perspectives in Biology

Reductive carboxylation supports growth in tumour cells with defective mitochondria

(2011) Andrew R. Mullen et al.   NATURE

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE