Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment

Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by intermittent anti-PI3Kα/β/δ treatment

(2022) Zhi Qi et al.   Nature Communications

Fumarate suppresses B-cell activation and function through direct inactivation of LYN

(2022) Jie Cheng et al.   Nature Chemical Biology

Integrated Molecular Characterization of Fumarate Hydratase-deficient Renal Cell Carcinoma

(2021) Guangxi Sun et al.   CLINICAL CANCER RESEARCH

Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses

(2021) Jun Wu et al.   NATURE CELL BIOLOGY

Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma

(2021) Kevin Bi et al.   CANCER CELL

Key chemokines direct migration of immune cells in solid tumors

(2021) Karan Kohli et al.   CANCER GENE THERAPY

A phase I study of anti‐BCMA CAR T cell therapy in relapsed/refractory multiple myeloma and plasma cell leukemia

(2021) Chunrui Li et al.   Clinical and Translational Medicine

Characterization of FH-deficient renal cell carcinoma

(2021) Louise Stone   Nature Reviews Urology

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

(2021) Shihao Xu et al.   IMMUNITY

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial C1qbp promotes differentiation of effector CD8 + T cells via metabolic-epigenetic reprogramming

(2021) Xingyuan Zhai et al.   Science Advances

Top 10 Challenges in Cancer Immunotherapy

(2020) Priti S. Hegde et al.   IMMUNITY

SciPy 1.0: fundamental algorithms for scientific computing in Python

(2020) Pauli Virtanen et al.   NATURE METHODS

Visualizing and interpreting cancer genomics data via the Xena platform

(2020) Mary J. Goldman et al.   NATURE BIOTECHNOLOGY

Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells

(2020) Teresa Manzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Array programming with NumPy

(2020) Charles R. Harris et al.   NATURE

Succination inactivates gasdermin D and blocks pyroptosis

(2020) Fiachra Humphries et al.   SCIENCE

A chemoproteomic portrait of the oncometabolite fumarate

(2019) Rhushikesh A. Kulkarni et al.   Nature Chemical Biology

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

(2019) Mark R Sullivan et al.   eLife

Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR

(2019) Sara Ghorashian et al.   NATURE MEDICINE

T Cell Activation Depends on Extracellular Alanine

(2019) Noga Ron-Harel et al.   Cell Reports

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

Engineering strategies to overcome the current roadblocks in CAR T cell therapy

(2019) Sarwish Rafiq et al.   Nature Reviews Clinical Oncology

IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis

(2019) Christina Lückel et al.   Nature Communications

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

(2018) Michael D. Kornberg et al.   SCIENCE

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Cancer immunoediting and resistance to T cell-based immunotherapy

(2018) Jake S. O’Donnell et al.   Nature Reviews Clinical Oncology

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

OpenMM 7: Rapid development of high performance algorithms for molecular dynamics

(2017) Peter Eastman et al.   PLoS Computational Biology

Nutrient and Metabolic Sensing in T Cell Responses

(2017) Jun Wei et al.   Frontiers in Immunology

Critical Role for CD103 + /CD141 + Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

(2016) Edward W. Roberts et al.   CANCER CELL

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Lymph node - an organ for T-cell activation and pathogen defense

(2016) Georg Gasteiger et al.   IMMUNOLOGICAL REVIEWS

Ionic immune suppression within the tumour microenvironment limits T cell effector function

(2016) Robert Eil et al.   NATURE

Emerging concepts of T cell metabolism as a target of immunotherapy

(2016) Chih-Hao Chang et al.   NATURE IMMUNOLOGY

Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

(2016) Fengju Chen et al.   Cell Reports

Hypoxia and antitumor CD8+ T cells: An incompatible alliance?

(2016) Romain Vuillefroy de Silly et al.   OncoImmunology

MDTraj: A Modern Open Library for the Analysis of Molecular Dynamics Trajectories

(2015) Robert T. McGibbon et al.   BIOPHYSICAL JOURNAL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

SnapShot: Immunometabolism

(2015) Peter J. Murray et al.   Cell Metabolism

Hypoxia Induces Production of L-2-Hydroxyglutarate

(2015) Andrew M. Intlekofer et al.   Cell Metabolism

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

Identification of Fumarate Hydratase Inhibitors with Nutrient-Dependent Cytotoxicity

(2015) Toshifumi Takeuchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Overcoming T cell exhaustion in infection and cancer

(2015) Kristen E. Pauken et al.   TRENDS IN IMMUNOLOGY

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker

(2013) Q. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Magnesium Ion–Water Coordination and Exchange in Biomolecular Simulations

(2012) Olof Allnér et al.   Journal of Chemical Theory and Computation

OpenMM 4: A Reusable, Extensible, Hardware Independent Library for High Performance Molecular Simulation

(2012) Peter Eastman et al.   Journal of Chemical Theory and Computation

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

(2012) David H. Munn et al.   TRENDS IN IMMUNOLOGY

An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

(2011) Aikseng Ooi et al.   CANCER CELL

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

ITAM-mediated Signaling by the T-Cell Antigen Receptor

(2010) P. E. Love et al.   Cold Spring Harbor Perspectives in Biology

ZAP-70: An Essential Kinase in T-cell Signaling

(2010) H. Wang et al.   Cold Spring Harbor Perspectives in Biology

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY