YTHDC1 as a tumor progression suppressor through modulating FSP1-dependent ferroptosis suppression in lung cancer

Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones

(2023) Deguang Liang et al.   CELL

YTHDC1 positively regulates PTEN expression and plays a critical role in cisplatin resistance of bladder cancer

(2023) Yinjie Su et al.   CELL PROLIFERATION

Ferroptosis: mechanisms and implications for cancer development and therapy response

(2023) Ancély Ferreira dos Santos et al.   TRENDS IN CELL BIOLOGY

FSP1: a key regulator of ferroptosis

(2023) Wentao Li et al.   TRENDS IN MOLECULAR MEDICINE

Alternative polyadenylation by sequential activation of distal and proximal PolyA sites

(2022) Peng Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The RNA-binding protein HuR in human cancer: A friend or foe?

(2022) Xiaoqing Wu et al.   ADVANCED DRUG DELIVERY REVIEWS

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers

(2022) Pranavi Koppula et al.   Nature Communications

Roles and mechanisms of the m6A reader YTHDC1 in biological processes and diseases

(2022) Huaqing Yan et al.   Cell Death Discovery

m 6 A RNA methylation: from mechanisms to therapeutic potential

(2021) P Cody He et al.   EMBO JOURNAL

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The emerging roles of RNA m6A methylation and demethylation as critical regulators of tumorigenesis, drug sensitivity, and resistance

(2021) Qing Lan et al.   CANCER RESEARCH

Alternative polyadenylation: methods, mechanism, function, and role in cancer

(2021) Yi Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity

(2021) Jiadong Liu et al.   NATURE

The RNA binding proteins YTHDC1 and FMRP regulate the nuclear export of N6-methyladenosine modified Hepatitis B Virus transcripts and affect the viral life cycle

(2021) Geon-Woo Kim et al.   JOURNAL OF VIROLOGY

On the Cutting Edge: Regulation and Therapeutic Potential of the mRNA 3′ End Nuclease

(2021) Huiyun Liu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation

(2021) Pia Sommerkamp et al.   TRENDS IN MOLECULAR MEDICINE

Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos

(2021) Chuan Chen et al.   Protein & Cell

Immune infiltration-related N6-methyladenosine RNA methylation regulators influence the malignancy and prognosis of endometrial cancer

(2021) Jian Ma et al.   Aging-US

Alternative polyadenylation dysregulation contributes to the differentiation block of acute myeloid leukemia

(2021) Amanda G Davis et al.   BLOOD

A Critical Role of Nuclear m6A Reader YTHDC1 in Leukemogenesis by Regulating MCM Complex-Mediated DNA Replication

(2021) Yue Sheng et al.   BLOOD

N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation

(2021) Yuanming Cheng et al.   CANCER CELL

Organelle-specific regulation of ferroptosis

(2021) Xin Chen et al.   CELL DEATH AND DIFFERENTIATION

Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation

(2021) Joo-Hyung Lee et al.   MOLECULAR CELL

The multifaceted effects of YTHDC1-mediated nuclear m6A recognition

(2021) Jocelyn Widagdo et al.   TRENDS IN GENETICS

Alternative polyadenylation: An enigma of transcript length variation in health and disease

(2021) Neeraja K. Mohanan et al.   Wiley Interdisciplinary Reviews-RNA

m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

(2020) Huilin Huang et al.   CANCER CELL

Ferroptosis: machinery and regulation

(2020) Xin Chen et al.   Autophagy

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

(2019) Hailing Shi et al.   MOLECULAR CELL

Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation

(2019) Tongxing Song et al.   NUCLEIC ACIDS RESEARCH

N6-methyladenosine Modulates Nonsense-mediated mRNA Decay in Human Glioblastoma

(2019) Fuxi Li et al.   CANCER RESEARCH

A powerful cell-protection system prevents cell death by ferroptosis

(2019) Brent R. Stockwell   NATURE

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development

(2018) Seth D. Kasowitz et al.   PLoS Genetics

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein-Protein Interactions

(2018) Weirui Ma et al.   CELL

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

(2017) Ian A Roundtree et al.   eLife

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

GPC5, a novel epigenetically silenced tumor suppressor, inhibits tumor growth by suppressing Wnt/β-catenin signaling in lung adenocarcinoma

(2016) S Yuan et al.   ONCOGENE

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

(2016) Shang-Jui Wang et al.   Cell Reports

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL