YTHDC1 positively regulates PTEN expression and plays a critical role in cisplatin resistance of bladder cancer

Defining cisplatin eligibility in patients with muscle-invasive bladder cancer

(2021) Di Maria Jiang et al.   Nature Reviews Urology

KNSTRN promotes tumorigenesis and gemcitabine resistance by activating AKT in bladder cancer

(2021) Yaoyi Xiong et al.   ONCOGENE

The m6A Methyltransferase METTL14-Mediated N6-Methyladenosine Modification of PTEN mRNA Inhibits Tumor Growth and Metastasis in Stomach Adenocarcinoma

(2021) Qi Yao et al.   Frontiers in Oncology

m6A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin

(2021) Diefei Liang et al.   Autophagy

ALKBH5 promotes cadmium-induced transformation of human bronchial epithelial cells by regulating PTEN expression in an m6A-dependent manner

(2021) Luyao Li et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Roles of METTL3 in cancer: mechanisms and therapeutic targeting

(2020) Chengwu Zeng et al.   Journal of Hematology & Oncology

Bladder Cancer

(2020) Andrew T. Lenis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target

(2020) Huarong Chen et al.   GASTROENTEROLOGY

The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network

(2019) Maosheng Cheng et al.   ONCOGENE

Mechanisms of PTEN loss in cancer: It’s all about diversity

(2019) Virginia Álvarez-Garcia et al.   SEMINARS IN CANCER BIOLOGY

AKT as a Therapeutic Target for Cancer

(2019) Mengqiu Song et al.   CANCER RESEARCH

Cellular Senescence: Aging, Cancer, and Injury

(2019) Arianna Calcinotto et al.   PHYSIOLOGICAL REVIEWS

Cisplatin: The first metal based anticancer drug

(2019) Sumit Ghosh   BIOORGANIC CHEMISTRY

KIAA1429 acts as an oncogenic factor in breast cancer by regulating CDK1 in an N6-methyladenosine-independent manner

(2019) Jia-Yi Qian et al.   ONCOGENE

Akt in cancer: Mediator and more

(2019) Sundaramoorthy Revathidevi et al.   SEMINARS IN CANCER BIOLOGY

The functions and regulation of the PTEN tumour suppressor: new modes and prospects

(2018) Yu-Ru Lee et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

XPC deficiency leads to centrosome amplification by inhibiting BRCA1 expression upon cisplatin-mediated DNA damage in human bladder cancer

(2018) Huanhuan Wang et al.   CANCER LETTERS

Autophagy substrate SQSTM1/p62 regulates chromatin ubiquitination during the DNA damage response

(2016) Yanan Wang et al.   Autophagy

Chemotherapy for Muscle-Invasive Bladder Cancer

(2016) Patrizia Trenta et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Higher expression of XPF is a critical factor in intrinsic chemotherapy resistance of human renal cell carcinoma

(2016) Qiao Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

The interplay between DNA repair and autophagy in cancer therapy

(2015) Dan Zhang et al.   CANCER BIOLOGY & THERAPY

DNA damage response – A double-edged sword in cancer prevention and cancer therapy

(2015) Hui Tian et al.   CANCER LETTERS

Whole–genome characterization of chemoresistant ovarian cancer

(2015) Ann-Marie Patch et al.   NATURE

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

The dynamic epitranscriptome: N6-methyladenosine and gene expression control

(2014) Kate D. Meyer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genomic Instability in Cancer

(2013) T. Abbas et al.   Cold Spring Harbor Perspectives in Biology

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Molecular Imaging Reveals a Role for AKT in Resistance to Cisplatin for Ovarian Endometrioid Adenocarcinoma

(2012) H. Wang et al.   CLINICAL CANCER RESEARCH

Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1

(2012) Lee Siggens et al.   FASEB JOURNAL

The DNA damage response and cancer therapy

(2012) Christopher J. Lord et al.   NATURE

HDACs link the DNA damage response, processing of double-strand breaks and autophagy

(2011) Thomas Robert et al.   NATURE

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

The mTOR Inhibitor Rapamycin Suppresses DNA Double-Strand Break Repair

(2010) Honghong Chen et al.   RADIATION RESEARCH

Cdk1 Participates in BRCA1-Dependent S Phase Checkpoint Control in Response to DNA Damage

(2009) Neil Johnson et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Effect of tumor suppressor gene PTEN on the resistance to cisplatin in human ovarian cancer cell lines and related mechanisms

(2008) HuiJuan Wu et al.   CANCER LETTERS

The role of PTEN signaling perturbations in cancer and in targeted therapy

(2008) M Keniry et al.   ONCOGENE