Silencing geranylgeranyltransferase I inhibits the migration and invasion of salivary adenoid cystic carcinoma through RhoA/ROCK1/MLC signaling and suppresses proliferation through cell cycle regulation

Dll4/Notch1 signalling pathway is required in collective invasion of salivary adenoid cystic carcinoma

(2021) Ke Wang et al.   ONCOLOGY REPORTS

Rhosin Suppressed Tumor Cell Metastasis through Inhibition of Rho/YAP Pathway and Expression of RHAMM and CXCR4 in Melanoma and Breast Cancer Cells

(2021) Masanobu Tsubaki et al.   Biomedicines

Circ-NOLC1 promotes epithelial ovarian cancer tumorigenesis and progression by binding ESRP1 and modulating CDK1 and RhoA expression

(2021) Shuo Chen et al.   Cell Death Discovery

Molecular and Pharmacological Characterization of the Interaction between Human Geranylgeranyltransferase Type I and Ras-Related Protein Rap1B

(2021) Sonja Hinz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

miR‐5191 acts as a tumor suppressor in salivary adenoid cystic carcinoma by targeting Notch‐2

(2021) Zhi Li et al.   ORAL DISEASES

Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma

(2021) Xiao Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

CXCR5 induces perineural invasion of salivary adenoid cystic carcinoma by inhibiting microRNA-187

(2021) Mei Zhang et al.   Aging-US

Hhex inhibits cell migration via regulating RHOA/CDC42-CFL1 axis in human lung cancer cells

(2021) Xiaopeng Li et al.   Cell Communication and Signaling

CXCL12/CXCR4 facilitates perineural invasion via induction of the Twist/S100A4 axis in salivary adenoid cystic carcinoma

(2021) Mei Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The MYC oncogene — the grand orchestrator of cancer growth and immune evasion

(2021) Renumathy Dhanasekaran et al.   Nature Reviews Clinical Oncology

Protein kinase D1 induced epithelial–mesenchymal transition and invasion in salivary adenoid cystic carcinoma via E‐cadherin/Snail regulation

(2021) Yue Du et al.   ORAL DISEASES

RhoGTPase Signalling in Cancer Progression and Dissemination

(2021) Eva Crosas-Molist et al.   PHYSIOLOGICAL REVIEWS

The RHO Family GTPases: Mechanisms of Regulation and Signaling

(2021) Niloufar Mosaddeghzadeh et al.   Cells

Role of Rho GTPases in stem cell regulation

(2021) Zheng Zhang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Clinical Implication of E2F Transcription Factor 1 in Hepatocellular Carcinoma Tissues

(2021) Wang-Yang Ye et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

N6-Methyladenosine Reader YTHDF1 Promotes ARHGEF2 Translation and RhoA Signaling in Colorectal Cancer

(2021) Shiyan Wang et al.   GASTROENTEROLOGY

Sphk1 promotes salivary adenoid cystic carcinoma progression via PI3K/Akt signaling

(2021) Chen-xing Hou et al.   PATHOLOGY RESEARCH AND PRACTICE

Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA

(2021) Junyi Wang et al.   Cell Death & Disease

miR-20b-5p functions as tumor suppressor microRNA by targeting cyclinD1 in colon cancer

(2020) Hui Yang et al.   CELL CYCLE

Fatty acid synthase contributes to epithelial‐mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/β‐catenin pathway

(2020) Wei‐long Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The circular RNAs differential expression profiles in the metastasis of salivary adenoid cystic carcinoma cells

(2020) Rui Ju et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

CASC9 plays a role in salivary adenoid cystic carcinoma in vitro by upregulation of ACLY

(2020) Hongliang Xie et al.   ORAL DISEASES

Correction: The Rho/ROCK pathway for lysophosphatidic acid-induced proteolytic enzyme expression and ovarian cancer cell invasion

(2019) K. J. Jeong et al.   ONCOGENE

Rho GTPases in cancer: friend or foe?

(2019) Julius H. Svensmark et al.   ONCOGENE

LncRNA LINC00974 Downregulates miR-122 to Upregulate RhoA in Oral Squamous Cell Carcinoma

(2019) Yanyan Tian et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration

(2019) Joseph H.R. Hetmanski et al.   DEVELOPMENTAL CELL

Involvement of partial EMT in cancer progression

(2018) Masao Saitoh   JOURNAL OF BIOCHEMISTRY

Regulation of RhoA GTPase and various transcription factors in the RhoA pathway

(2018) Jae-Gyu Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Paving the Rho in cancer metastasis: Rho GTPases and beyond

(2018) Sepp Jansen et al.   PHARMACOLOGY & THERAPEUTICS

E2F1 silencing inhibits migration and invasion of osteosarcoma cells via regulating DDR1 expression

(2017) Zhaofeng Wang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

EMT and inflammation: inseparable actors of cancer progression

(2017) Meggy Suarez-Carmona et al.   Molecular Oncology

Synthesis of an ethyleneimine/tetrahedral DNA nanostructure complex and its potential application as a multi-functional delivery vehicle

(2017) Taoran Tian et al.   Nanoscale

Clinical Management of Potential Toxicities and Drug Interactions Related to Cyclin‐Dependent Kinase 4/6 Inhibitors in Breast Cancer: Practical Considerations and Recommendations

(2017) Laura M. Spring et al.   ONCOLOGIST

miR-509-5p and miR-1243 increase the sensitivity to gemcitabine by inhibiting epithelial-mesenchymal transition in pancreatic cancer

(2017) Hidekazu Hiramoto et al.   Scientific Reports

Expression of SKA1 and MMP–9 in primary salivary adenoid cystic carcinoma: Correlation with tumor progression and patient prognosis

(2016) Lijuan Zhao et al.   ACTA OTO-LARYNGOLOGICA

Protein Geranylgeranyltransferase Type 1 as a Target in Cancer

(2016) Nisar Ullah et al.   CURRENT CANCER DRUG TARGETS

E2F1 promotes tumor cell invasion and migration through regulating CD147 in prostate cancer

(2016) YU-XIANG LIANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Structural Mechanisms and Drug Discovery Prospects of Rho GTPases

(2016) Cameron Smithers et al.   Cells

Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis

(2015) Fariborz Mortazavi et al.   BMC CANCER

Farnesyltransferase and geranylgeranyltransferase I: structures, mechanism, inhibitors and molecular modeling

(2015) Mingyun Shen et al.   DRUG DISCOVERY TODAY

The Role of Geranylgeranyltransferase I-Mediated Protein Prenylation in the Brain

(2015) Shangfeng Gao et al.   MOLECULAR NEUROBIOLOGY

E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells

(2015) Minghui Wu et al.   Oncotarget

HepaCAM inhibits clear cell renal carcinoma 786-0 cell proliferation via blocking PKCε translocation from cytoplasm to plasma membrane

(2014) Bing Tan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Expression of RECK and MMP-2 in salivary adenoid cystic carcinoma: Correlation with tumor progression and patient prognosis

(2014) XIAOQING ZHOU et al.   Oncology Letters

Rho/Rho-Associated Coiled-Coil Forming Kinase Pathway as Therapeutic Targets for Statins in Atherosclerosis

(2013) Naoki Sawada et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting GGTase-I Activates RHOA, Increases Macrophage Reverse Cholesterol Transport, and Reduces Atherosclerosis in Mice

(2013) Omar M. Khan et al.   CIRCULATION

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

Geranylgeranyltransferase I Promotes Human Glioma Cell Growth through Rac1 Membrane Association and Activation

(2012) Xiuping Zhou et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Regulation of MT1-MMP and MMP-2 by Leptin in Cardiac Fibroblasts Involves Rho/ROCK-Dependent Actin Cytoskeletal Reorganization and Leads to Enhanced Cell Migration

(2011) Kristin Schram et al.   ENDOCRINOLOGY

TGF-β1 Promotes Migration and Invasion of Salivary Adenoid Cystic Carcinoma

(2011) L. Dong et al.   JOURNAL OF DENTAL RESEARCH

Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signalling

(2011) Y C Liao et al.   ONCOGENE

Determinants and Patterns of Survival in Adenoid Cystic Carcinoma of the Head and Neck, Including an Analysis of Adjuvant Radiation Therapy

(2010) Shane Lloyd et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis

(2010) Brad A. Bryan et al.   FASEB JOURNAL

Pamidronate, farnesyl transferase, and geranylgeranyl transferase-I inhibitors affects cell proliferation, apoptosis, and OPG/RANKL mRNA expression in stromal cells of giant cell tumor of bone

(2010) Carol P.Y. Lau et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL