Geranylgeranyltransferase I Promotes Human Glioma Cell Growth through Rac1 Membrane Association and Activation

RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer

(2012) R. A. Patel et al.   CANCER RESEARCH

In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion

(2012) Eishu Hirata et al.   JOURNAL OF CELL SCIENCE

FRK controls migration and invasion of human glioma cells by regulating JNK/c-Jun signaling

(2012) Xiuping Zhou et al.   JOURNAL OF NEURO-ONCOLOGY

Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle

(2011) Saeid Ghavami et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Role of Rho GTPases and their regulators in cancer progression

(2011) Rajamani Rathinam   Frontiers in Bioscience-Landmark

Targeted suicide gene therapy for glioma using human embryonic stem cell-derived neural stem cells genetically modified by baculoviral vectors

(2011) Y Zhao et al.   GENE THERAPY

Standard of care therapy for malignant glioma and its effect on tumor and stromal cells

(2011) T S Jones et al.   ONCOGENE

Activin B Promotes Epithelial Wound Healing In Vivo through RhoA-JNK Signaling Pathway

(2011) Min Zhang et al.   PLoS One

Rho protein crosstalk: another social network?

(2011) Christophe Guilluy et al.   TRENDS IN CELL BIOLOGY

Involvement of RhoA and RalB in geranylgeranyltransferase I inhibitor-mediated inhibition of proliferation and migration of human oral squamous cell carcinoma cells

(2010) Masakazu Hamada et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways

(2010) Hiromichi Nakabayashi et al.   CANCER SCIENCE

Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells

(2010) Sanna S Virtanen et al.   CELL BIOLOGY INTERNATIONAL

Rac and Rho GTPases in cancer cell motility control

(2010) Matteo Parri et al.   Cell Communication and Signaling

A p27kip1-binding Protein, p27RF-Rho, Promotes Cancer Metastasis via Activation of RhoA and RhoC

(2010) Daisuke Hoshino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipidation by the Host Prenyltransferase Machinery Facilitates Membrane Localization ofLegionella pneumophilaEffector Proteins

(2010) Stanimir S. Ivanov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Geranylgeranyl Transferase Inhibitor in Combination with Lovastatin Inhibits Proliferation and Induces Autophagy in STS-26T MPNST Cells

(2010) K. M. Sane et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inactivating GGTase-I reduces disease phenotypes in a mouse model of K-RAS-induced myeloproliferative disease

(2010) A-K M Sjogren et al.   LEUKEMIA

Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer

(2010) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Geranylgeranyltransferase I is essential for dendritic development of cerebellar Purkinje cells

(2010) Kong-Yan Wu et al.   Molecular Brain

TrkBT1 Induces Liver Metastasis of Pancreatic Cancer Cells by Sequestering Rho GDP Dissociation Inhibitor and Promoting RhoA Activation

(2009) Z. Li et al.   CANCER RESEARCH

Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27Kip1 Phosphorylation on Thr187 and Accumulates p27Kip1 in the Nucleus: Implications for Breast Cancer Therapy

(2009) A. Kazi et al.   MOLECULAR AND CELLULAR BIOLOGY

In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I

(2009) J. Lu et al.   MOLECULAR CANCER THERAPEUTICS

Rho GTPases in PC-3 prostate cancer cell morphology, invasion and tumor cell diapedesis

(2008) Linda Sequeira et al.   CLINICAL & EXPERIMENTAL METASTASIS

RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells

(2008) Mirvat El-Sibai et al.   EXPERIMENTAL CELL RESEARCH

TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis

(2008) X.-P. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA