Melatonin attenuates sevoflurane-induced hippocampal damage and cognitive deficits in neonatal mice by suppressing CypD in parvalbumin neurons

Long-term sevoflurane exposure resulted in temporary rather than lasting cognitive impairment in Drosophila

(2023) Ziming Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Sevoflurane Induces a Cyclophilin D-Dependent Decrease of Neural Progenitor Cells Migration

(2023) Pan Lu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prolonged exposure of neonatal mice to sevoflurane leads to hyper-ramification in microglia, reduced contacts between microglia and synapses, and defects in adult behavior

(2023) Hong Li et al.   Frontiers in Neurology

Brain Iron Metabolism, Redox Balance and Neurological Diseases

(2023) Guofen Gao et al.   Antioxidants

Disease Outcome and Brain Metabolomics of Cyclophilin-D Knockout Mice in Sepsis

(2022) Takayuki Kobayashi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin Attenuates Ischemia/Reperfusion-Induced Oxidative Stress by Activating Mitochondrial Fusion in Cardiomyocytes

(2022) Xiaoling Ma et al.   Oxidative Medicine and Cellular Longevity

Sevoflurane inhibits histone acetylation and contributes to cognitive dysfunction by enhancing the expression of ANP32A in aging mice

(2022) Gaoshang Chai et al.   BEHAVIOURAL BRAIN RESEARCH

Neuroglobin alleviates the neurotoxicity of sevoflurane to fetal rats by inhibiting neuroinflammation and affecting microglial polarization

(2022) Yongfang Zhang et al.   BRAIN RESEARCH BULLETIN

SIRT3-Mediated CypD-K166 Deacetylation Alleviates Neuropathic Pain by Improving Mitochondrial Dysfunction and Inhibiting Oxidative Stress

(2022) Binbin Yan et al.   Oxidative Medicine and Cellular Longevity

General anesthesia in children and long-term neurodevelopmental deficits: A systematic review

(2022) Aoyi Xiao et al.   Frontiers in Molecular Neuroscience

Melatonin and metformin counteract cognitive dysfunction equally in male rats with doxorubicin-induced chemobrain

(2022) Titikorn Chunchai et al.   NEUROTOXICOLOGY

Anesthesia and developing brain: What have we learned from recent studies

(2022) Yixuan Niu et al.   Frontiers in Molecular Neuroscience

Maternal oxidative stress during pregnancy and offspring neurodevelopment

(2021) Claudia Buss   BRAIN BEHAVIOR AND IMMUNITY

Effect of basal forebrain somatostatin and parvalbumin neurons in propofol and isoflurane anesthesia

(2021) Shuang Cai et al.   CNS Neuroscience & Therapeutics

As part of multimodal anxiolysis oral melatonin but not midazolam decreases emergence delirium in children

(2021) Lily Singla et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Melatonin’s neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders

(2021) Lindsay M. Melhuish Beaupre et al.   Translational Psychiatry

Neonatal exposure to sevoflurane caused learning and memory impairment via dysregulating SK2 channel endocytosis

(2021) Wentao Ke et al.   SCIENCE PROGRESS

The neuroprotective role of melatonin against methamphetamine toxicity-induced neurotransmission dysregulation and cognitive deficits in rats

(2021) Natcharee Kraiwattanapirom et al.   FOOD AND CHEMICAL TOXICOLOGY

Associations between Melatonin, Neuroinflammation, and Brain Alterations in Depression

(2021) Eunsoo Won et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin pretreatment alleviates the long‐term synaptic toxicity and dysmyelination induced by neonatal Sevoflurane exposure via MT1 receptor‐mediated Wnt signaling modulation

(2021) Lirong Liang et al.   JOURNAL OF PINEAL RESEARCH

Effect of Melatonin Administration on Mitochondrial Activity and Oxidative Stress Markers in Patients with Parkinson’s Disease

(2021) Alicia Jiménez-Delgado et al.   Oxidative Medicine and Cellular Longevity

Melatonin enhances SIRT1 to ameliorate mitochondrial membrane damage by activating PDK1/Akt in granulosa cells of PCOS

(2021) Bo Zheng et al.   Journal of Ovarian Research

Silencing of PTEN inhibits the oxidative stress damage and hippocampal cell apoptosis induced by Sevoflurane through activating MEK1/ERK signaling pathway in infant rats

(2020) Tiejun Liu et al.   CELL CYCLE

Cyclophilin D Contributes to Anesthesia Neurotoxicity in the Developing Brain

(2020) Yiying Zhang et al.   Frontiers in Cell and Developmental Biology

Cyclophilin D counterbalances mitochondrial calcium uniporter-mediated brain mitochondrial calcium uptake

(2020) Bei Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain

(2020) Yulim Lee et al.   NEUROTOXICOLOGY

Sevoflurane increases intracellular calcium to induce mitochondrial injury and neuroapoptosis

(2020) Xiaoqiu Zhu et al.   TOXICOLOGY LETTERS

Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial

(2019) Mary Ellen McCann et al.   LANCET

Cognitive impairment and transcriptomic profile in hippocampus of young mice after multiple neonatal exposures to sevoflurane

(2019) Shao-Yong Song et al.   Aging-US

Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3

(2019) Jinpiao Zhu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Sevoflurane postconditioning improves spatial learning and memory ability involving mitochondrial permeability transition pore in hemorrhagic shock and resuscitation rats

(2019) Li Zhang et al.   Brain and Behavior

Exposure of Developing Brain to General Anesthesia

(2018) Vesna Jevtovic-Todorovic   ANESTHESIOLOGY

Different doses of sevoflurane facilitate and impair learning and memory function through activation of the ERK pathway and synthesis of ARC protein in the rat hippocampus

(2018) Qian-Lin Zhu et al.   BRAIN RESEARCH

Cyclophilin D regulates neuronal activity-induced filopodiagenesis by fine-tuning dendritic mitochondrial calcium dynamics

(2018) Shaomei Sui et al.   JOURNAL OF NEUROCHEMISTRY

Inhibitory effect of melatonin on necroptosis via repressing the Ripk3-PGAM5-CypD-mPTP pathway attenuates cardiac microvascular ischemia-reperfusion injury

(2018) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Sevoflurane impairs learning and memory of the developing brain through post-transcriptional inhibition of CCNA2 via microRNA-19-3p

(2018) Xin Zhao et al.   Aging-US

Treatment with Melatonin Improves Cognitive Behavior and Motor Skills in a Rat Model of Liver Fibrosis.

(2018) Paola Haeger et al.   Annals of Hepatology

A clinical review of inhalation anesthesia with sevoflurane: from early research to emerging topics

(2017) Jorge D. Brioni et al.   Journal of Anesthesia

Prevention of Cyclophilin D-Mediated mPTP Opening Using Cyclosporine-A Alleviates the Elevation of Necroptosis, Autophagy and Apoptosis-Related Markers Following Global Cerebral Ischemia-Reperfusion

(2016) Farinoosh Fakharnia et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Repeated Neonatal Sevoflurane Exposure-Induced Developmental Delays of Parvalbumin Interneurons and Cognitive Impairments Are Reversed by Environmental Enrichment

(2016) Mu-huo Ji et al.   MOLECULAR NEUROBIOLOGY

Exposure to Sevoflurane Affects the Development of Parvalbumin Interneurons in the Main Olfactory Bulb in Mice

(2016) Jing Yang et al.   Frontiers in Neuroanatomy

Analgesic, Anxiolytic and Anaesthetic Effects of Melatonin: New Potential Uses in Pediatrics

(2015) Lucia Marseglia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin facilitates adipose-derived mesenchymal stem cells to repair the murine infarcted heartviathe SIRT1 signaling pathway

(2015) Dong Han et al.   JOURNAL OF PINEAL RESEARCH

Cognition and Brain Structure Following Early Childhood Surgery With Anesthesia

(2015) B. Backeljauw et al.   PEDIATRICS

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Sevoflurane-Induced Down-regulation of Hippocampal Oxytocin and Arginine Vasopressin Impairs Juvenile Social Behavioral Abilities

(2014) Zhi-Bin Zhou et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A double-blind, placebo-controlled intervention trial of 3 and 10 mg sublingual melatonin for post-concussion syndrome in youths (PLAYGAME): study protocol for a randomized controlled trial

(2014) Karen M Barlow et al.   Trials

Melatonin regulates the calcium-buffering proteins, parvalbumin and hippocalcin, in ischemic brain injury

(2012) Phil-Ok Koh   JOURNAL OF PINEAL RESEARCH

Early Childhood Exposure to Anesthesia and Risk of Developmental and Behavioral Disorders in a Sibling Birth Cohort

(2011) Charles DiMaggio et al.   ANESTHESIA AND ANALGESIA

Effects of chronic intermittent hypoxia on genioglossus in rats

(2011) Hanpeng Huang et al.   Sleep and Breathing

Munc18 and Munc13 regulate early neurite outgrowth

(2010) Jurjen H.P. Broeke et al.   BIOLOGY OF THE CELL