General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain

Mitochondrial Proteases: Multifaceted Regulators of Mitochondrial Plasticity

(2020) Soni Deshwal et al.   Annual Review of Biochemistry

Sex differences in neurodevelopmental abnormalities caused by early-life anaesthesia exposure: a narrative review

(2020) Omar H. Cabrera et al.   BRITISH JOURNAL OF ANAESTHESIA

Conflicting Actions of Inhalational Anesthetics, Neurotoxicity and Neuroprotection, Mediated by the Unfolded Protein Response

(2020) Hiroshi Kokubun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial stress protein HSP60 regulates ER stress-induced hepatic lipogenesis

(2020) Ting Xiao et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Early Adversity and Critical Periods: Neurodevelopmental Consequences of Violating the Expectable Environment

(2020) Charles A. Nelson et al.   TRENDS IN NEUROSCIENCES

The Role of Mitochondria in Neurodegenerative Diseases: the Lesson from Alzheimer’s Disease and Parkinson’s Disease

(2020) Giacomo Monzio Compagnoni et al.   MOLECULAR NEUROBIOLOGY

Signaling and Regulation of the Mitochondrial Unfolded Protein Response

(2019) Nandhitha Uma Naresh et al.   Cold Spring Harbor Perspectives in Biology

Relevance of experimental paradigms of anesthesia induced neurotoxicity in the mouse

(2019) Simon C. Johnson et al.   PLoS One

Powerhouse of the mind: mitochondrial plasticity at the synapse

(2019) Meghan J Rossi et al.   CURRENT OPINION IN NEUROBIOLOGY

Chloramphenicol Mitigates Oxidative Stress by Inhibiting Translation of Mitochondrial Complex I in Dopaminergic Neurons of Toxin-Induced Parkinson’s Disease Model

(2019) Jeongsu Han et al.   Oxidative Medicine and Cellular Longevity

Isoflurane disrupts excitatory neurotransmitter dynamics via inhibition of mitochondrial complex I

(2018) P.I. Zimin et al.   BRITISH JOURNAL OF ANAESTHESIA

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

(2018) Andrew Melber et al.   CELL RESEARCH

Estimating pediatric general anesthesia exposure: Quantifying duration and risk

(2018) Devan Darby Bartels et al.   PEDIATRIC ANESTHESIA

Anesthesia affects excitatory/inhibitory synapses during the critical synaptogenic period in the hippocampus of young mice: Importance of sex as a biological variable

(2018) Xianshu Ju et al.   NEUROTOXICOLOGY

Endoplasmic reticulum stress mediates distinct impacts of sevoflurane on different subfields of immature hippocampus

(2017) Gang Zhu et al.   JOURNAL OF NEUROCHEMISTRY

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1

(2017) Masahiro Morita et al.   MOLECULAR CELL

Review of preclinical studies on pediatric general anesthesia-induced developmental neurotoxicity

(2017) Jennifer L. Walters et al.   NEUROTOXICOLOGY AND TERATOLOGY

Preventing permeability transition pore opening increases mitochondrial maturation, myocyte differentiation and cardiac function in the neonatal mouse heart

(2017) Jayson V. Lingan et al.   PEDIATRIC RESEARCH

BDNF pathway is involved in the protective effects of SS-31 on isoflurane-induced cognitive deficits in aging mice

(2016) Jing Wu et al.   BEHAVIOURAL BRAIN RESEARCH

Sevoflurane-Induced Endoplasmic Reticulum Stress Contributes to Neuroapoptosis and BACE-1 Expression in the Developing Brain: The Role of eIF2α

(2016) Bin Liu et al.   NEUROTOXICITY RESEARCH

Mitochondrial Impairment in Cerebrovascular Endothelial Cells is Involved in the Correlation between Body Temperature and Stroke Severity

(2016) Heng Hu et al.   Aging and Disease

Autophagy Is Involved in the Sevoflurane Anesthesia-Induced Cognitive Dysfunction of Aged Rats

(2016) Xiaoming Zhang et al.   PLoS One

Long-term Effects of Single or Multiple Neonatal Sevoflurane Exposures on Rat Hippocampal Ultrastructure

(2015) Levana G. Amrock et al.   ANESTHESIOLOGY

Sensitive and critical periods during neurotypical and aberrant neurodevelopment: A framework for neurodevelopmental disorders

(2015) R.M. Meredith   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

A Mitochondrion-Targeted Antioxidant Ameliorates Isoflurane-Induced Cognitive Deficits in Aging Mice

(2015) Jing Wu et al.   PLoS One

Brain regional vulnerability to anaesthesia-induced neuroapoptosis shifts with age at exposure and extends into adulthood for some regions

(2014) M. Deng et al.   BRITISH JOURNAL OF ANAESTHESIA

Mitochondrial dysfunction, oxidative stress and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson’s model

(2014) A Ray et al.   Cell Death & Disease

Sevoflurane causes neuronal apoptosis and adaptability changes of neonatal rats

(2013) S. Q. ZHENG et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Mitochondrial protectant pramipexole prevents sex-specific long-term cognitive impairment from early anaesthesia exposure in rats

(2013) A. Boscolo et al.   BRITISH JOURNAL OF ANAESTHESIA

Modeling Transformations of Neurodevelopmental Sequences across Mammalian Species

(2013) A. D. Workman et al.   JOURNAL OF NEUROSCIENCE

Expression of autophagy and UPR genes in the developing brain during ethanol-sensitive and resistant periods

(2013) Alexander Alimov et al.   METABOLIC BRAIN DISEASE

Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response

(2013) Eva D. Runkel et al.   PLoS Genetics

Mitochondrial Protein Synthesis, Import, and Assembly

(2012) Thomas D. Fox   GENETICS

General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain

(2011) Victoria Sanchez et al.   ANESTHESIOLOGY

A mitochondrial etiology of Alzheimer and Parkinson disease

(2011) Pinar Coskun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The abolishment of anesthesia-induced cognitive impairment by timely protection of mitochondria in the developing rat brain: The importance of free oxygen radicals and mitochondrial integrity

(2011) A. Boscolo et al.   NEUROBIOLOGY OF DISEASE

Volatile Anesthetics Rapidly Increase Dendritic Spine Density in the Rat Medial Prefrontal Cortex during Synaptogenesis

(2010) Adrian Briner et al.   ANESTHESIOLOGY

The Conformational Dynamics of the Mitochondrial Hsp70 Chaperone

(2010) Koyeli Mapa et al.   MOLECULAR CELL

Subclinical concentration of sevoflurane potentiates neuronal apoptosis in the developing C57BL/6 mouse brain

(2008) Xiaoguang Zhang et al.   NEUROSCIENCE LETTERS