Discovery of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent and selective heparanase-1 inhibitor utilizing an improved synthetic approach

Understanding patient and parent/caregiver perceptions on gene therapy in Gaucher disease: an international survey

(2023) Tanya Collin-Histed et al.   Orphanet Journal of Rare Diseases

Targeting the GBA1 pathway to slow Parkinson disease: Insights into clinical aspects, pathogenic mechanisms and new therapeutic avenues

(2023) Elisa Menozzi et al.   PHARMACOLOGY & THERAPEUTICS

Pediatric Gaucher Disease Presenting with Massive Splenomegaly and Hepatic Gaucheroma

(2023) Gianluca Bossù et al.   Children-Basel

Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor

(2023) Yudai Imai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction

(2022) Scott E. Guimond et al.   ACS Central Science

Adipose deficiency and aberrant autophagy in a Drosophila model of MPS VII is corrected by pharmacological stimulators of mTOR

(2022) Indrani Basu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Perinatal lethal Gaucher disease: A case report and review of literature

(2022) Rie Chida et al.   BRAIN & DEVELOPMENT

Heparanase: A Novel Therapeutic Target for the Treatment of Atherosclerosis

(2022) Tien K. Nguyen et al.   Cells

Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor

(2022) Yudai Imai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Diagnosis and Emerging Treatment Strategies for Mucopolysaccharidosis VII (Sly Syndrome)

(2022) Fabiano de Oliveira Poswar et al.   Therapeutics and Clinical Risk Management

Randomised phase II trial of gemcitabine and nab-paclitaxel with necuparanib or placebo in untreated metastatic pancreas ductal adenocarcinoma

(2020) Eileen M. O'Reilly et al.   EUROPEAN JOURNAL OF CANCER

Heparanase and the hallmarks of cancer

(2020) Krishnath M. Jayatilleke et al.   Journal of Translational Medicine

Vestronidase Alfa: A Review in Mucopolysaccharidosis VII

(2019) Emma H. McCafferty et al.   BIODRUGS

Phase I study of the heparanase inhibitor Roneparstat: an innovative approach for multiple myeloma therapy

(2018) Monica Galli et al.   HAEMATOLOGICA

Phase I study of the heparanase inhibitor Roneparstat: an innovative approach for multiple myeloma therapy

(2018) Monica Galli et al.   HAEMATOLOGICA

Inhibition of heparanase protects against chronic kidney dysfunction following ischemia/reperfusion injury

(2018) Valentina Masola et al.   Oncotarget

Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis

(2016) Marjolein Garsen et al.   AMERICAN JOURNAL OF PATHOLOGY

Heparanase and cancer progression: New directions, new promises

(2016) Gil Arvatz et al.   Human Vaccines & Immunotherapeutics

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synthesis and evaluation of 3-deoxy and 3-deoxy-3-fluoro derivatives of gluco- and manno-configured tetrahydropyridoimidazole glycosidase inhibitors

(2013) Cécile Ouairy et al.   CARBOHYDRATE RESEARCH

The role of heparanase and the endothelial glycocalyx in the development of proteinuria

(2013) Marjolein Garsen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Synthesis of (2-{4-[4-Fluoro-3-(trifluoromethyl)phenyl]-2-piperidin-4-yl-1H-imidazol-1-yl}ethyl)dimethylamine

(2013) Radhe Vaid et al.   SYNTHESIS-STUTTGART

Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues

(2013) Edward Hammond et al.   FEBS Open Bio

Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice

(2011) N. Gil et al.   DIABETES

M402, a Novel Heparan Sulfate Mimetic, Targets Multiple Pathways Implicated in Tumor Progression and Metastasis

(2011) He Zhou et al.   PLoS One

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Development of Specific “Drug-Like Property” Rules for Carboxylate-Containing Oral Drug Candidates

(2010) Alexander Böcker et al.   ChemMedChem

Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer

(2009) M. Khasraw et al.   ANNALS OF ONCOLOGY

Efficient one-pot synthetic protocols for iminosugar-bearing imidazo[1,2-a]pyridines from carbohydrates

(2009) Lal Dhar S. Yadav et al.   CARBOHYDRATE RESEARCH

Cathepsin L Is Responsible for Processing and Activation of Proheparanase through Multiple Cleavages of a Linker Segment

(2008) Ghada Abboud-Jarrous et al.   JOURNAL OF BIOLOGICAL CHEMISTRY