Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor

Understanding patient and parent/caregiver perceptions on gene therapy in Gaucher disease: an international survey

(2023) Tanya Collin-Histed et al.   Orphanet Journal of Rare Diseases

Sulfated Hyaluronan Binds to Heparanase and Blocks Its Enzymatic and Cellular Actions in Carcinoma Cells

(2022) Jia Shi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adipose deficiency and aberrant autophagy in a Drosophila model of MPS VII is corrected by pharmacological stimulators of mTOR

(2022) Indrani Basu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Perinatal lethal Gaucher disease: A case report and review of literature

(2022) Rie Chida et al.   BRAIN & DEVELOPMENT

Heparanase: A Novel Therapeutic Target for the Treatment of Atherosclerosis

(2022) Tien K. Nguyen et al.   Cells

Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor

(2022) Yudai Imai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Diagnosis and Emerging Treatment Strategies for Mucopolysaccharidosis VII (Sly Syndrome)

(2022) Fabiano de Oliveira Poswar et al.   Therapeutics and Clinical Risk Management

Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity

(2021) Hsien-Ya Lin et al.   Communications Biology

Fragment molecular orbital calculations for biomolecules

(2021) Kaori Fukuzawa et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Heparanase and the hallmarks of cancer

(2020) Krishnath M. Jayatilleke et al.   Journal of Translational Medicine

Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish

(2019) Marta Artola et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Vestronidase Alfa: A Review in Mucopolysaccharidosis VII

(2019) Emma H. McCafferty et al.   BIODRUGS

Phase I study of the heparanase inhibitor Roneparstat: an innovative approach for multiple myeloma therapy

(2018) Monica Galli et al.   HAEMATOLOGICA

Phase I study of the heparanase inhibitor Roneparstat: an innovative approach for multiple myeloma therapy

(2018) Monica Galli et al.   HAEMATOLOGICA

Inhibition of heparanase protects against chronic kidney dysfunction following ischemia/reperfusion injury

(2018) Valentina Masola et al.   Oncotarget

Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis

(2016) Marjolein Garsen et al.   AMERICAN JOURNAL OF PATHOLOGY

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural characterization of human heparanase reveals insights into substrate recognition

(2015) Liang Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synthesis and evaluation of 3-deoxy and 3-deoxy-3-fluoro derivatives of gluco- and manno-configured tetrahydropyridoimidazole glycosidase inhibitors

(2013) Cécile Ouairy et al.   CARBOHYDRATE RESEARCH

GAMESS As a Free Quantum-Mechanical Platform for Drug Research

(2013) Yuri Alexeev et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Lysosomal β-glucuronidase regulates Lyme and rheumatoid arthritis severity

(2013) Kenneth K.C. Bramwell et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of heparanase and the endothelial glycocalyx in the development of proteinuria

(2013) Marjolein Garsen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Synthesis of a Pseudo-Disaccharide Library and Its Application to the Characterisation of the Heparanase Catalytic Site

(2013) Victoria Vinader et al.   PLoS One

Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues

(2013) Edward Hammond et al.   FEBS Open Bio

Exploring chemistry with the fragment molecular orbital method

(2012) Dmitri G. Fedorov et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Structure–activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as β-glucosidase inhibitors

(2011) Tiehai Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice

(2011) N. Gil et al.   DIABETES

Development of Specific “Drug-Like Property” Rules for Carboxylate-Containing Oral Drug Candidates

(2010) Alexander Böcker et al.   ChemMedChem

Efficient parallel algorithm of second-order Møller-Plesset perturbation theory with resolution-of-identity approximation (RI-MP2)

(2009) Michio Katouda et al.   INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY

Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: A randomized phase II trial for safety and optimal dosage

(2009) Chun-Jen Liu et al.   JOURNAL OF HEPATOLOGY

Cathepsin L Is Responsible for Processing and Activation of Proheparanase through Multiple Cleavages of a Linker Segment

(2008) Ghada Abboud-Jarrous et al.   JOURNAL OF BIOLOGICAL CHEMISTRY