Reactive architecture profiling with a methyl acyl phosphate electrophile

2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases

(2023) Peng Chen et al.   Journal of the American Chemical Society

Global profiling of lysine lactylation in human lungs

(2023) Ye‐Hong Yang et al.   PROTEOMICS

Combined inactivation of CTPS1 and ATR is synthetically lethal to MYC-overexpressing cancer cells

(2022) Zhe Sun et al.   CANCER RESEARCH

CTPS1 promotes malignant progression of triple-negative breast cancer with transcriptional activation by YBX1

(2022) Yuxiang Lin et al.   Journal of Translational Medicine

Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases

(2022) Weili Miao et al.   JOURNAL OF PROTEOME RESEARCH

Proteome-Wide Characterizations of N6-Methyl-Adenosine Triphosphate- and N6-Furfuryl-Adenosine Triphosphate-Binding Capabilities of Kinases

(2021) Xuejiao Dong et al.   ANALYTICAL CHEMISTRY

Development and application of novel electrophilic warheads in target identification and drug discovery

(2021) Yue Liu et al.   BIOCHEMICAL PHARMACOLOGY

A proteome-wide atlas of lysine-reactive chemistry

(2021) Mikail E. Abbasov et al.   Nature Chemistry

Recent progress in covalent warheads for in vivo targeting of endogenous proteins

(2021) Naoya Shindo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeted Quantitative Profiling of GTP-Binding Proteins Associated with Metastasis of Melanoma Cells

(2021) Rong Cai et al.   JOURNAL OF PROTEOME RESEARCH

Structural basis for isoform-specific inhibition of human CTPS1

(2021) Eric M. Lynch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Click Chemistry in Proteomic Investigations

(2020) Christopher G. Parker et al.   CELL

Chemical Proteomic Profiling of the Interacting Proteins of Isoprenoid Pyrophosphates

(2020) Rong Cai et al.   ANALYTICAL CHEMISTRY

Activity-based protein profiling: Recent advances in medicinal chemistry

(2020) Hui Deng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bioorthogonal Reactions in Activity-Based Protein Profiling

(2020) Steven H. L. Verhelst et al.   MOLECULES

Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6

(2019) Eric S. Okerberg et al.   BIOCHEMISTRY

Chemical Proteomic Profiling of Lysophosphatidic Acid-Binding Proteins

(2019) Xuejiao Dong et al.   ANALYTICAL CHEMISTRY

Contributions to nucleosome dynamics in chromatin from interactive propagation of phosphorylation/acetylation and inducible histone lysine basicities

(2018) Lois R. Manning et al.   PROTEIN SCIENCE

A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK

(2018) Laurent R. Chiarelli et al.   Scientific Reports

A CTP Synthase Undergoing Stage-Specific Spatial Expression Is Essential for the Survival of the Intracellular Parasite Toxoplasma gondii

(2018) Heidy Y. Narvaez-Ortiz et al.   Frontiers in Cellular and Infection Microbiology

Global profiling of lysine reactivity and ligandability in the human proteome

(2017) Stephan M. Hacker et al.   Nature Chemistry

A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors

(2017) Marta Esposito et al.   ACS Infectious Diseases

A High-Throughput Targeted Proteomic Approach for Comprehensive Profiling of Methylglyoxal-Induced Perturbations of the Human Kinome

(2016) Weili Miao et al.   ANALYTICAL CHEMISTRY

BlastKOALA and GhostKOALA: KEGG Tools for Functional Characterization of Genome and Metagenome Sequences

(2016) Minoru Kanehisa et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics

(2016) Eric S. Okerberg et al.   PLoS One

Target identification with quantitative activity based protein profiling (ABPP)

(2016) Xiao Chen et al.   PROTEOMICS

Structural insights into the catalytic reaction trigger and inhibition ofD-3-hydroxybutyrate dehydrogenase

(2016) Hiroki Kanazawa et al.   Acta Crystallographica Section F-Structural Biology Communications

ATP Acyl Phosphate Reactivity Reveals Native Conformations of Hsp90 Paralogs and Inhibitor Target Engagement

(2015) Brian E. Nordin et al.   BIOCHEMISTRY

Inactivation of Mandelate Racemase by 3-Hydroxypyruvate Reveals a Potential Mechanistic Link between Enzyme Superfamilies

(2015) Mitesh Nagar et al.   BIOCHEMISTRY

Activity-Based Protein Profiling: Recent Advances in Probe Development and Applications

(2015) Pengyu Yang et al.   CHEMBIOCHEM

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

(2015) Giorgia Mori et al.   CHEMISTRY & BIOLOGY

Activity-based protein profiling of microbes

(2015) Natalie C Sadler et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Covalent protein modification: the current landscape of residue-specific electrophiles

(2015) D Alexander Shannon et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The SEQUEST Family Tree

(2015) David L. Tabb   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Enzyme Inhibitor Discovery by Activity-Based Protein Profiling

(2014) Micah J. Niphakis et al.   Annual Review of Biochemistry

Current Developments in Activity-Based Protein Profiling

(2014) Lianne I. Willems et al.   BIOCONJUGATE CHEMISTRY

Small-molecule probes elucidate global enzyme activity in a proteomic context

(2014) Jun-Seok Lee et al.   BMB Reports

Activity-based proteomic and metabolomic approaches for understanding metabolism

(2014) Devon Hunerdosse et al.   CURRENT OPINION IN BIOTECHNOLOGY

Monitoring Native p38α:MK2/3 Complexes via Trans Delivery of an ATP Acyl Phosphate Probe

(2014) Eric S. Okerberg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Targeted Quantitative Proteomics Strategy for Global Kinome Profiling of Cancer Cells and Tissues

(2014) Yongsheng Xiao et al.   MOLECULAR & CELLULAR PROTEOMICS

A Quantitative Chemical Proteomics Approach to Profile the Specific Cellular Targets of Andrographolide, a Promising Anticancer Agent That Suppresses Tumor Metastasis

(2014) Jigang Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation

(2014) Emmanuel Martin et al.   NATURE

Large-scale filament formation inhibits the activity of CTP synthetase

(2014) Rachael M Barry et al.   eLife

A Chemical Proteomics Approach to Profiling the ATP-binding Proteome ofMycobacterium tuberculosis

(2013) Lisa M. Wolfe et al.   MOLECULAR & CELLULAR PROTEOMICS

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

Classification and nomenclature of the superfamily of short-chain dehydrogenases/reductases (SDRs)

(2012) Bengt Persson et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Activity-based protein profiling: an enabling technology in chemical biology research

(2012) Nan Li et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Activation and inhibition of CTP synthase from Trypanosoma brucei, the causative agent of African sleeping sickness

(2011) Craig H. Steeves et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural and Catalytic Properties of the D-3-Hydroxybutyrate Dehydrogenase from Pseudomonas aeruginosa

(2010) Driss Mountassif et al.   CURRENT MICROBIOLOGY

The metabolic enzyme CTP synthase forms cytoskeletal filaments

(2010) Michael Ingerson-Mahar et al.   NATURE CELL BIOLOGY

Structure ofD-3-hydroxybutyrate dehydrogenase prepared in the presence of the substrateD-3-hydroxybutyrate and NAD+

(2009) Md Mominul Hoque et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Closed Complex of the D-3-Hydroxybutyrate Dehydrogenase Induced by an Enantiomeric Competitive Inhibitor

(2009) K. Nakashima et al.   JOURNAL OF BIOCHEMISTRY

Normalization and Statistical Analysis of Quantitative Proteomics Data Generated by Metabolic Labeling

(2009) Lily Ting et al.   MOLECULAR & CELLULAR PROTEOMICS

The structures ofAlcaligenes faecalisD-3-hydroxybutyrate dehydrogenase before and after NAD+and acetate binding suggest a dynamical reaction mechanism as a member of the SDR family

(2008) Md Mominul Hoque et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

(2008) Benjamin F. Cravatt et al.   Annual Review of Biochemistry

Medium- and short-chain dehydrogenase/reductase gene and protein families

(2008) K. L. Kavanagh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

pKa-Dependent Formation of Amides in Water from an Acyl Phosphate Monoester and Amines

(2008) Jolanta Wodzinska et al.   JOURNAL OF ORGANIC CHEMISTRY

Disparate proteome reactivity profiles of carbon electrophiles

(2008) Eranthie Weerapana et al.   Nature Chemical Biology