Bioorthogonal Reactions in Activity-Based Protein Profiling

Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugs.

(2020) Jennifer A. Ward et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity

(2020) Nattawadee Panyain et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Developing bioorthogonal probes to span a spectrum of reactivities

(2020) Sean S. Nguyen et al.   Nature Reviews Chemistry

Activity‐based protein profiling of chitin catabolism

(2020) Elias K. Zegeye et al.   CHEMBIOCHEM

Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos

(2020) Raymond Kooij et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cover Feature: Comparison of Bioorthogonal β‐Lactone Activity‐Based Probes for Selective Labeling of Penicillin‐Binding Proteins (ChemBioChem 1/2021)

(2020) Nathaniel W. Brown et al.   CHEMBIOCHEM

Recent developments in bioorthogonal chemistry and the orthogonality within

(2020) Mike L.W.J. Smeenk et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Recent Advances in Bioorthogonal Click Chemistry for Efficient Synthesis of Radiotracers and Radiopharmaceuticals

(2019) Mushtaq et al.   MOLECULES

Structure Dependent Determination of Organophosphate Targets in Mammalian Tissues Using Activity-Based Protein Profiling

(2019) Vivian S. Lin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells

(2019) Sebastiaan T. A. Koenders et al.   ACS Central Science

Advances in Tetrazine Bioorthogonal Chemistry Driven by the Synthesis of Novel Tetrazines and Dienophiles

(2018) Haoxing Wu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Vinylboronic Acids as Efficient Bioorthogonal Reactants for Tetrazine Labeling in Living Cells

(2018) Selma Eising et al.   BIOCONJUGATE CHEMISTRY

Pretargeting in nuclear imaging and radionuclide therapy: Improving efficacy of theranostics and nanomedicines

(2018) E. Johanna L. Stéen et al.   BIOMATERIALS

Coordination-Assisted Bioorthogonal Chemistry: Orthogonal Tetrazine Ligation with Vinylboronic Acid and a Strained Alkene

(2018) Selma Eising et al.   CHEMBIOCHEM

Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP)

(2018) Christian S. Lentz et al.   Nature Chemical Biology

Development of an activity-based probe for acyl-protein thioesterases

(2018) Megan Garland et al.   PLoS One

Bioconjugation with Maleimides: A useful Tool for Chemical Biology

(2018) Pedro Miguel pimenta Gois et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asking more from metabolic oligosaccharide engineering

(2018) Pierre-André Gilormini et al.   Chemical Science

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

(2017) Annelot C. M. van Esbroeck et al.   SCIENCE

Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic Archaea

(2017) Susanne Zweerink et al.   Nature Communications

Benzimidazole covalent probes and the gastric H+/K+-ATPase as a model system for protein labeling in a copper-free setting

(2016) Chelsea J. Paresi et al.   Molecular BioSystems

In-gel activity-based protein profiling of a clickable covalent ERK1/2 inhibitor

(2016) Honorine Lebraud et al.   Molecular BioSystems

Tetrazine ligation for chemical proteomics

(2016) Kyungtae Kang et al.   Proteome Science

Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing

(2015) Eliane V. Wolf et al.   ACS Chemical Biology

Activity-Based Protein Profiling: Recent Advances in Probe Development and Applications

(2015) Pengyu Yang et al.   CHEMBIOCHEM

Global profiling of protein lipidation using chemical proteomic technologies

(2015) Edward W Tate et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Orthogonal bioorthogonal chemistries

(2015) David M Patterson et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study

(2015) Nora Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Sulfonyl fluorides as privileged warheads in chemical biology

(2015) Arjun Narayanan et al.   Chemical Science

Multiplex Imaging and Cellular Target Identification of Kinase Inhibitors via an Affinity-Based Proteome Profiling Approach

(2015) Ying Su et al.   Scientific Reports

Finding the Right (Bioorthogonal) Chemistry

(2014) David M. Patterson et al.   ACS Chemical Biology

Ultrafluorogenic Coumarin-Tetrazine Probes for Real-Time Biological Imaging

(2014) Labros G. Meimetis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Chelating Azides for Efficient Click Conjugation Reactions in Complex Media

(2014) Valentina Bevilacqua et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme Inhibitor Discovery by Activity-Based Protein Profiling

(2014) Micah J. Niphakis et al.   Annual Review of Biochemistry

Monitoring Dynamic Glycosylation in Vivo Using Supersensitive Click Chemistry

(2014) Hao Jiang et al.   BIOCONJUGATE CHEMISTRY

Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins

(2014) Kathrin Lang et al.   CHEMICAL REVIEWS

Applications of Copper-Catalyzed Click Chemistry in Activity-Based Protein Profiling

(2014) Julianne Martell et al.   MOLECULES

Acylazetine as a Dienophile in Bioorthogonal Inverse Electron-Demand Diels–Alder Ligation

(2014) Sander B. Engelsma et al.   ORGANIC LETTERS

Biocompatible click chemistry enabled compartment-specific pH measurement inside E. coli

(2014) Maiyun Yang et al.   Nature Communications

Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation

(2013) Ron M. Versteegen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Optimizing the selectivity of DIFO-based reagents for intracellular bioorthogonal applications

(2013) Eun J. Kim et al.   CARBOHYDRATE RESEARCH

Comparative Analysis of Click Chemistry Mediated Activity-Based Protein Profiling in Cell Lysates

(2013) Yinliang Yang et al.   MOLECULES

Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion

(2013) Matthew A Child et al.   Nature Chemical Biology

Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS

(2013) Nan Li et al.   Nature Protocols

Cell-permeable probe for identification and imaging of sialidases

(2013) C.-S. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay

(2013) O. Vosyka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BODIPY based ‘click on’ fluorogenic dyes: application in live cell imaging

(2013) Dinesh Pratapsinh Chauhan et al.   TETRAHEDRON LETTERS

Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling

(2012) Chayasith Uttamapinant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Triple Bioorthogonal Ligation Strategy for Simultaneous Labeling of Multiple Enzymatic Activities

(2012) Lianne I. Willems et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Preventing Thiol-Yne Addition Improves the Specificity of Strain-Promoted Azide–Alkyne Cycloaddition

(2012) Remon van Geel et al.   BIOCONJUGATE CHEMISTRY

Tuning probe selectivity for chemical proteomics applications

(2012) Ute Haedke et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling

(2011) Lianne I. Willems et al.   ACCOUNTS OF CHEMICAL RESEARCH

Alkyne derivatives of isocoumarins as clickable activity-based probes for serine proteases

(2011) Ute Haedke et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: A comparative study

(2011) Wouter A. van der Linden et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Development and characterization of improved β-lactone-based anti-virulence drugs targeting ClpP

(2011) Evelyn Zeiler et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Activity-Based Profiling of Retaining β-Glucosidases: A Comparative Study

(2011) Martin D. Witte et al.   CHEMBIOCHEM

Multi-molecule reaction of serum albumin can occur through thiol-yne coupling

(2011) Mauro Lo Conte et al.   CHEMICAL COMMUNICATIONS

The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease

(2011) Jonathan Z. Long et al.   CHEMICAL REVIEWS

Cellular Consequences of Copper Complexes Used To Catalyze Bioorthogonal Click Reactions

(2011) David C. Kennedy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion

(2011) C. I. Hall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice

(2010) Raffaella Rossin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells

(2010) Neal K. Devaraj et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two-Step Labeling of Endogenous Enzymatic Activities by Diels-Alder Ligation

(2010) Lianne I. Willems et al.   CHEMBIOCHEM

Azide: A Unique Dipole for Metal-Free Bioorthogonal Ligations

(2010) Marjoke F. Debets et al.   CHEMBIOCHEM

Biocompatible Copper(I) Catalysts for in Vivo Imaging of Glycans

(2010) David Soriano del Amo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

(2010) D. A. Bachovchin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualizing Metabolically Labeled Glycoconjugates of Living Cells by Copper-Free and Fast Huisgen Cycloadditions

(2008) Xinghai Ning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging

(2008) Neal K. Devaraj et al.   BIOCONJUGATE CHEMISTRY

Azido‐BODIPY Acid Reveals Quantitative Staudinger–Bertozzi Ligation in Two‐Step Activity‐Based Proteasome Profiling

(2008) Martijn Verdoes et al.   CHEMBIOCHEM

Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry

(2008) Julian A. Codelli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Lactones as Specific Inhibitors of ClpP Attenuate the Production of Extracellular Virulence Factors ofStaphylococcus aureus

(2008) Thomas Böttcher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Hydrophilic Azacyclooctyne for Cu-Free Click Chemistry

(2008) Ellen M. Sletten et al.   ORGANIC LETTERS

Synthesis and Use of Mechanism-Based Protein-Profiling Probes for Retaining β-d-Glucosaminidases Facilitate Identification ofPseudomonas aeruginosaNagZ

(2007) Keith A. Stubbs et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY