Targeting bacterial degradation machinery as an antibacterial strategy

Structural Analysis of Bacillus subtilis Sigma Factors

(2023) Katherine M. Collins et al.   Microorganisms

3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC

(2022) Yuqian Yan et al.   CHEMICAL COMMUNICATIONS

Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules

(2022) Mark F. Mabanglo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BacPROTACs mediate targeted protein degradation in bacteria

(2022) Francesca E. Morreale et al.   CELL

Antibacterial peptide CyclomarinA creates toxicity by deregulating the Mycobacterium tuberculosis ClpC1–ClpP1P2 protease

(2022) Gabrielle Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ESKAPE Pathogens: Looking at Clp ATPases as Potential Drug Targets

(2022) Tehrim Motiwala et al.   Antibiotics-Basel

Heat activates the AAA+ HslUV protease by melting an axial autoinhibitory plug

(2021) Vladimir Baytshtok et al.   Cell Reports

ClpC-Mediated Sporulation Regulation at Engulfment Stage in Bacillus anthracis

(2021) Nishant Kumar et al.   INDIAN JOURNAL OF MICROBIOLOGY

Applications of Bacterial Degrons and Degraders — Toward Targeted Protein Degradation in Bacteria

(2021) Matylda Anna Izert et al.   Frontiers in Molecular Biosciences

Reprogramming of the Caseinolytic Protease by ADEP Antibiotics: Molecular Mechanism, Cellular Consequences, Therapeutic Potential

(2021) Heike Brötz-Oesterhelt et al.   Frontiers in Molecular Biosciences

The rise and rise of protein degradation: Opportunities and challenges ahead

(2021) Scott J. Hughes et al.   DRUG DISCOVERY TODAY

Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease

(2021) Shanshan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of the ClpXP Protease Leads to Decreased Resistance to Cell-Envelope Targeting Antimicrobials in Bacillus anthracis Sterne

(2021) Lang Zou et al.   Frontiers in Microbiology

The AAA+ superfamily: a review of the structural and mechanistic principles of these molecular machines

(2021) Yousuf A. Khan et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Lon protease temporally restricts polar cell differentiation events during the Caulobacter cell cycle

(2021) Deike J Omnus et al.   eLife

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

(2020) Xue Fei et al.   eLife

A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

(2020) Zev A Ripstein et al.   eLife

The Science of Antibiotic Discovery

(2020) Kim Lewis   CELL

The unfoldase ClpC1 of Mycobacterium tuberculosis regulates the expression of a distinct subset of proteins having intrinsically disordered termini

(2020) Ajitesh Lunge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the N-terminal domain of ClpC1 in complex with the antituberculosis natural product ecumicin reveals unique binding interactions

(2020) Nina M. Wolf et al.   Acta Crystallographica Section D-Structural Biology

Shaping an Endospore: Architectural Transformations During Bacillus subtilis Sporulation

(2020) Kanika Khanna et al.   Annual Review of Microbiology

Understanding the Metabolism of Proteolysis Targeting Chimeras (PROTACs): The Next Step toward Pharmaceutical Applications

(2020) Laura Goracci et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus

(2019) Mary P. Choules et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High-Resolution Structure of ClpC1-Rufomycin and Ligand Binding Studies Provide a Framework to Design and Optimize Anti-Tuberculosis Leads

(2019) Nina M. Wolf et al.   ACS Infectious Diseases

Leveraging Peptide Substrate Libraries to Design Inhibitors of Bacterial Lon Protease

(2019) Brett M. Babin et al.   ACS Chemical Biology

PROTACs– a game-changing technology

(2019) Markella Konstantinidou et al.   Expert Opinion on Drug Discovery

Degradation of proteins by PROTACs and other strategies

(2019) Yang Wang et al.   Acta Pharmaceutica Sinica B

Antibiotics: past, present and future

(2019) Matthew I Hutchings et al.   CURRENT OPINION IN MICROBIOLOGY

Light-Induced Protein Degradation with Photocaged PROTACs

(2019) Gang Xue et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cryo-EM structure of the ClpXP protein degradation machinery

(2019) Christos Gatsogiannis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stairway to translocation: AAA+ motor structures reveal the mechanisms of ATP‐dependent substrate translocation

(2019) Stephanie N. Gates et al.   PROTEIN SCIENCE

Ureadepsipeptides as ClpP Activators

(2019) Elizabeth C. Griffith et al.   ACS Infectious Diseases

The antibiotic cyclomarin blocks arginine-phosphate–induced millisecond dynamics in the N-terminal domain of ClpC1 fromMycobacterium tuberculosis

(2018) Katharina Weinhäupl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ClpY-ClpQ protease regulates multicellular development in Bacillus subtilis

(2018) Yiyang Yu et al.   MICROBIOLOGY-SGM

Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control

(2017) Marta Carroni et al.   eLife

Bacterial proteases, untapped antimicrobial drug targets

(2016) Elizabeth Culp et al.   JOURNAL OF ANTIBIOTICS

Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity

(2016) Jordan D. Goodreid et al.   JOURNAL OF MEDICINAL CHEMISTRY

Arginine phosphorylation marks proteins for degradation by a Clp protease

(2016) Débora Broch Trentini et al.   NATURE

The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer’s Disease and Spinal Cord Injury

(2016) Bing Gong et al.   Frontiers in Molecular Neuroscience

ClpB N-terminal domain plays a regulatory role in protein disaggregation

(2015) Rina Rosenzweig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phthalimide conjugation as a strategy for in vivo target protein degradation

(2015) G. E. Winter et al.   SCIENCE

AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control

(2015) Malte Gersch et al.   Nature Communications

The Cyclic Peptide Ecumicin Targeting ClpC1 Is Active against Mycobacterium tuberculosis In Vivo

(2014) Wei Gao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2

(2014) Ekaterina Gavrish et al.   CHEMISTRY & BIOLOGY

Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery

(2014) K. R. Schmitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Mycobacterial Inhibition by Cyclomarin A

(2013) Dileep Vasudevan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activated ClpP kills persisters and eradicates a chronic biofilm infection

(2013) B. P. Conlon et al.   NATURE

Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs

(2013) J. Hines et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Bacillus subtilis endospore: assembly and functions of the multilayered coat

(2012) Peter T. McKenney et al.   NATURE REVIEWS MICROBIOLOGY

The Natural Product Cyclomarin Kills Mycobacterium Tuberculosis by Targeting the ClpC1 Subunit of the Caseinolytic Protease

(2011) Esther K. Schmitt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure and mechanism of the hexameric MecA–ClpC molecular machine

(2011) Feng Wang et al.   NATURE

Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ

(2011) P. Sass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The future of the β-lactams

(2010) Leticia I Llarrull et al.   CURRENT OPINION IN MICROBIOLOGY

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

(2010) Byung-Gil Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY