Mitophagy in yeast: known unknowns and unknown unknowns

The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy

(2023) Tomoyuki Fukuda et al.   MOLECULAR CELL

Determinants and outcomes of mitochondrial dynamics

(2023) Rubén Quintana-Cabrera et al.   MOLECULAR CELL

Completion of mitochondrial division requires the intermembrane space protein Mdi1/Atg44

(2023) Olivia M. Connor et al.   JOURNAL OF CELL BIOLOGY

The pyruvate dehydrogenase complex regulates mitophagic trafficking and protein phosphorylation

(2023) Panagiota Kolitsida et al.   Life Science Alliance

DarT-mediated mtDNA damage induces dynamic reorganization and selective segregation of mitochondria

(2022) Nitish Dua et al.   JOURNAL OF CELL BIOLOGY

In‐depth and 3‐dimensional exploration of the budding yeast phosphoproteome

(2021) Michael C Lanz et al.   EMBO REPORTS

Cross-compartment signal propagation in the mitotic exit network

(2021) Xiaoxue Zhou et al.   eLife

Mitophagy regulation mediated by the Far complex in yeast

(2021) Kentaro Furukawa et al.   Autophagy

The protein N-terminal acetyltransferase A complex contributes to yeast mitophagy via promoting expression and phosphorylation of Atg32

(2021) Mitsutaka Kubota et al.   JOURNAL OF BIOCHEMISTRY

Atg32 dependent mitophagy sustains spermidine and nitric oxide required for heat stress tolerance in S. cerevisiae

(2021) Jasvinder Kaur et al.   JOURNAL OF CELL SCIENCE

Mitochondrial Heterogeneity in Metabolic Diseases

(2021) Jennifer Ngo et al.   Biology-Basel

Subcellular Specialization of Mitochondrial Form and Function in Skeletal Muscle Cells

(2021) T. Bradley Willingham et al.   Frontiers in Cell and Developmental Biology

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

(2020) Leena P. Bharath et al.   Cell Metabolism

Mitophagy improves ethanol tolerance in yeast: regulation by mitochondrial reactive oxygen species in Saccharomyces cerevisiae

(2020) Hongjuan Jing et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

The yeast mitophagy receptor Atg32 is ubiquitinated and degraded by the proteasome

(2020) Nadine Camougrand et al.   PLoS One

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 leading to activation of mitophagy

(2019) Liangde Zheng et al.   Autophagy

Phosphorylation of mitochondrial matrix proteins regulates their selective mitophagic degradation

(2019) Panagiota Kolitsida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ER membrane insertase Get1/2 is required for efficient mitophagy in yeast

(2018) Mashun Onishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The TORC1 signaling pathway regulates respiration-induced mitophagy in yeast

(2018) Yang Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The GET pathway can increase the risk of mitochondrial outer membrane proteins to be mistargeted to the ER

(2018) Daniela G. Vitali et al.   JOURNAL OF CELL SCIENCE

The PP2A-like Protein Phosphatase Ppg1 and the Far Complex Cooperatively Counteract CK2-Mediated Phosphorylation of Atg32 to Inhibit Mitophagy

(2018) Kentaro Furukawa et al.   Cell Reports

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Autophagy induction under carbon starvation conditions is negatively regulated by carbon catabolite repression

(2017) Atsuhiro Adachi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrative proteomics and biochemical analyses define Ptc6p as theSaccharomyces cerevisiaepyruvate dehydrogenase phosphatase

(2017) Xiao Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiolipin Regulates Mitophagy through the Protein Kinase C Pathway

(2017) Zheni Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial fission facilitates the selective mitophagy of protein aggregates

(2017) Jonathon L. Burman et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial depolarization in yeast zygotes inhibits clonal expansion of selfish mtDNA

(2017) Iuliia E. Karavaeva et al.   JOURNAL OF CELL SCIENCE

ESCRTs function directly on the lysosome membrane to downregulate ubiquitinated lysosomal membrane proteins

(2017) Lu Zhu et al.   eLife

Iron-depletion promotes mitophagy to maintain mitochondrial integrity in pathogenic yeastCandida glabrata

(2016) Minoru Nagi et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis

(2016) Vincent R. Richard et al.   Aging-US

Ceramide signalling impinges on Sit4p and Hog1p to promote mitochondrial fission and mitophagy in Isc1p-deficient cells

(2015) Vitor Teixeira et al.   CELLULAR SIGNALLING

Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling

(2015) K. Sakakibara et al.   EMBO JOURNAL

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

(2015) Tomokazu Murakawa et al.   Nature Communications

Synthetic Quantitative Array Technology Identifies the Ubp3-Bre5 Deubiquitinase Complex as a Negative Regulator of Mitophagy

(2015) Matthias Müller et al.   Cell Reports

Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A

(2014) Sunil Laxman et al.   Autophagy

Mitochondrial ER Contacts Are Crucial for Mitophagy in Yeast

(2014) Stefan Böckler et al.   DEVELOPMENTAL CELL

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Tor and the Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg32 in yeast

(2014) M. Aihara et al.   JOURNAL OF CELL SCIENCE

Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites

(2014) S. Laxman et al.   Science Signaling

Enhancement of Ethanol Fermentation in Saccharomyces cerevisiae Sake Yeast by Disrupting Mitophagy Function

(2013) Shodai Shiroma et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Proteolytic processing of Atg32 by the mitochondrial i-AAA protease Yme1 regulates mitophagy

(2013) Ke Wang et al.   Autophagy

Methionine Inhibits Autophagy and Promotes Growth by Inducing the SAM-Responsive Methylation of PP2A

(2013) Benjamin M. Sutter et al.   CELL

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

The Scaffold Protein Atg11 Recruits Fission Machinery to Drive Selective Mitochondria Degradation by Autophagy

(2013) Kai Mao et al.   DEVELOPMENTAL CELL

Casein kinase 2 is essential for mitophagy

(2013) Tomotake Kanki et al.   EMBO REPORTS

Phosphorylation of mitophagy and pexophagy receptors coordinates their interaction with Atg8 and Atg11

(2013) Jean-Claude Farré et al.   EMBO REPORTS

Uth1 is a mitochondrial inner membrane protein dispensable for post-log-phase and rapamycin-induced mitophagy

(2013) Evelyn Welter et al.   FEBS Journal

Autophagic Processes in Yeast: Mechanism, Machinery and Regulation

(2013) F. Reggiori et al.   GENETICS

Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation

(2013) Danielle L Swaney et al.   NATURE METHODS

Ptc6 Is Required for Proper Rapamycin-Induced Down-Regulation of the Genes Coding for Ribosomal and rRNA Processing Proteins in S. cerevisiae

(2013) Asier González et al.   PLoS One

Tissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model

(2013) R. H. Hamalainen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy

(2013) Hagai Abeliovich et al.   Nature Communications

ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast

(2013) Andrew Murley et al.   eLife

Autophagy-related Protein 32 Acts as Autophagic Degron and Directly Initiates Mitophagy

(2012) Noriko Kondo-Okamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control

(2011) Derek P. Narendra et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial elongation during autophagy

(2011) Ligia C. Gomes et al.   Autophagy

Mitochondrial AAA proteases — Towards a molecular understanding of membrane-bound proteolytic machines

(2011) Florian Gerdes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitophagy Plays an Essential Role in Reducing Mitochondrial Production of Reactive Oxygen Species and Mutation of Mitochondrial DNA by Maintaining Mitochondrial Quantity and Quality in Yeast

(2011) Yusuke Kurihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two MAPK-signaling pathways are required for mitophagy inSaccharomyces cerevisiae

(2011) Kai Mao et al.   JOURNAL OF CELL BIOLOGY

Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2

(2011) N. Mendl et al.   JOURNAL OF CELL SCIENCE

Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation

(2011) Xi Wu et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation of Serine 114 on Atg32 mediates mitophagy

(2011) Yoshimasa Aoki et al.   MOLECULAR BIOLOGY OF THE CELL

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Biophysical properties of mitochondrial fusion events in pancreatic β-cells and cardiac cells unravel potential control mechanisms of its selectivity

(2010) Gilad Twig et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A genomic screen for yeast mutants defective in mitophagy

(2010) Tomotake Kanki et al.   Autophagy

A landmark protein essential for mitophagy

(2009) Koji Okamoto et al.   Autophagy

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

(2009) Tomotake Kanki et al.   DEVELOPMENTAL CELL

Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

(2009) Koji Okamoto et al.   DEVELOPMENTAL CELL

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Hypoxia-induced BNIP3 expression and mitophagy: in vivo comparison of the rat and the hypoxia-tolerant mole rat, Spalax ehrenbergi

(2009) Mark Band et al.   FASEB JOURNAL

Aup1-mediated Regulation of Rtg3 during Mitophagy

(2009) Dikla Journo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione Participates in the Regulation of Mitophagy in Yeast

(2009) Maika Deffieu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Genomic Screen for Yeast Mutants Defective in Selective Mitochondria Autophagy

(2009) Tomotake Kanki et al.   MOLECULAR BIOLOGY OF THE CELL

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy

(2008) Ligia C. Gomes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Yeast Pyruvate Dehydrogenase Complex Is Regulated by a Concerted Activity of Two Kinases and Two Phosphatases

(2008) Uta Gey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy

(2008) Jiefei Geng et al.   JOURNAL OF CELL BIOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Short- and long-term alterations of mitochondrial morphology, dynamics and mtDNA after transient oxidative stress

(2008) Marina Jendrach et al.   MITOCHONDRION

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Isc1p Plays a Key Role in Hydrogen Peroxide Resistance and Chronological Lifespan through Modulation of Iron Levels and Apoptosis

(2007) Teresa Almeida et al.   MOLECULAR BIOLOGY OF THE CELL