Mitochondrial Heterogeneity in Metabolic Diseases

Nicotinamide Treatment Facilitates Mitochondrial Fission through Drp1 Activation Mediated by SIRT1-Induced Changes in Cellular Levels of cAMP and Ca2+

(2021) Seon Beom Song et al.   Cells

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

(2021) Peiling Luan et al.   Science Translational Medicine

Discovering Cellular Mitochondrial Heteroplasmy Heterogeneity with Single Cell RNA and ATAC Sequencing

(2021) Aidan S. Marshall et al.   Biology-Basel

Metabolic regulation of calcium signaling in beta cells

(2020) Olof Idevall-Hagren et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

NCLX prevents cell death during adrenergic activation of the brown adipose tissue

(2020) Essam A. Assali et al.   Nature Communications

Mitochondrial oxidative function in NAFLD: Friend or foe?

(2020) Michael Shum et al.   Molecular Metabolism

Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice

(2019) Stacey N. Keenan et al.   DIABETES

Mitochondrial Heterogeneity

(2019) Juvid Aryaman et al.   Frontiers in Genetics

Mitochondrial calcium: Transport and modulation of cellular processes in homeostasis and cancer (Review)

(2019) Susana Romero-Garcia et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent

(2019) Dane M Wolf et al.   EMBO JOURNAL

Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells

(2019) Tan et al.   Cells

MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes

(2019) Christophe A.C. Freyre et al.   MOLECULAR CELL

Mitochondrial carnitine palmitoyltransferase 2 is involved in Nε-(carboxymethyl)-lysine-mediated diabetic nephropathy

(2019) Jangho Lee et al.   PHARMACOLOGICAL RESEARCH

Mitochondrial membrane potential

(2018) Ljubava D. Zorova et al.   ANALYTICAL BIOCHEMISTRY

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion

(2018) Ilan Y. Benador et al.   Cell Metabolism

The role of beta cell heterogeneity in islet function and insulin release

(2018) Daniela Nasteska et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions

(2018) György Csordás et al.   TRENDS IN CELL BIOLOGY

Defining the short-term effects of pharmacological 5′-AMP activated kinase modulators on mitochondrial polarization, morphology and heterogeneity

(2018) Mohamed Kodiha et al.   PeerJ

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

Mitochondrial Heterogeneity: Evaluating Mitochondrial Subpopulation Dynamics in Stem Cells

(2017) D. C. Woods   Stem Cells International

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Mitochondria as therapeutic targets in acute kidney injury

(2016) Andrew M. Hall et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum–mitochondria tether

(2016) Deborah Naon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis

(2015) Chao Wang et al.   HEPATOLOGY

Liver Perilipin 5 Expression Worsens Hepatosteatosis But Not Insulin Resistance in High Fat-Fed Mice

(2015) Michelle B. Trevino et al.   MOLECULAR ENDOCRINOLOGY

Oxidative stress-induced mitochondrial fragmentation and movement in skeletal muscle myoblasts

(2014) Sobia Iqbal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes

(2014) Patrick Gilon et al.   CELL CALCIUM

Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway

(2014) C. Pennanen et al.   JOURNAL OF CELL SCIENCE

MitoTimer: a novel protein for monitoring mitochondrial turnover in the heart

(2014) Roberta A. Gottlieb et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

The endoplasmic reticulum–mitochondria connection: One touch, multiple functions

(2013) Saverio Marchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

Proximal Tubule Function and Response to Acidosis

(2013) N. P. Curthoys et al.   Clinical Journal of the American Society of Nephrology

Cell-to-Cell Heterogeneity in Lipid Droplets Suggests a Mechanism to Reduce Lipotoxicity

(2013) Albert Herms et al.   CURRENT BIOLOGY

Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology

(2013) Ming Zhan et al.   KIDNEY INTERNATIONAL

Mechanisms of Mitochondrial Fission and Fusion

(2013) A. M. van der Bliek et al.   Cold Spring Harbor Perspectives in Biology

Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity

(2013) S Xu et al.   Cell Death & Disease

Mitochondrial dynamics and morphology in beta-cells

(2012) Linsey Stiles et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Motility of astrocytic mitochondria is arrested by Ca2+-dependent interaction between mitochondria and actin filaments

(2012) Elena Kremneva et al.   CELL CALCIUM

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial Ca2+ homeostasis: mechanism, role, and tissue specificities

(2012) Paola Pizzo et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The Mitochondrial Ca2+ Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells

(2012) Andrei I. Tarasov et al.   PLoS One

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription

(2012) A.-B. Al-Mehdi et al.   Science Signaling

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

Mitochondrial signals drive insulin secretion in the pancreatic β-cell

(2011) Andreas Wiederkehr et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Progression of Diet-Induced Diabetes in C57BL6J Mice Involves Functional Dissociation of Ca2+ Channels From Secretory Vesicles

(2010) S. C. Collins et al.   DIABETES

An intimate liaison: spatial organization of the endoplasmic reticulum–mitochondria relationship

(2010) Olga Martins de Brito et al.   EMBO JOURNAL

Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1

(2010) Sören Mai et al.   JOURNAL OF CELL SCIENCE

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

(2010) D.-F. Suen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial fusion proteins: Dual regulators of morphology and metabolism

(2010) Antonio Zorzano et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Glucolipotoxicity of the pancreatic beta cell

(2009) Vincent Poitout et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca2+ Channels from Secretory Granules

(2009) Michael B. Hoppa et al.   Cell Metabolism

Mitochondrial Networking Protects  -Cells From Nutrient-Induced Apoptosis

(2009) A. J.A. Molina et al.   DIABETES

Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes

(2009) Antonio Zorzano et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

What can mitochondrial heterogeneity tell us about mitochondrial dynamics and autophagy?

(2009) Jakob D. Wikstrom et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Heterogeneity of Mitochondria and Mitochondrial Function within Cells as Another Level of Mitochondrial Complexity

(2009) Andrey Kuznetsov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial dynamics in heart cells: Very low amplitude high frequency fluctuations in adult cardiomyocytes and flow motion in non beating Hl-1 cells

(2009) Nathalie Beraud et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

(2009) Craig Brooks et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Dynamics in Mammalian Health and Disease

(2009) Marc Liesa et al.   PHYSIOLOGICAL REVIEWS

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

The sensitivity of pancreatic β-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress

(2008) Ning Li et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view

(2008) Gilad Twig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species

(2008) Tianzheng Yu et al.   CARDIOVASCULAR RESEARCH

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction

(2008) Vincent Poitout et al.   ENDOCRINE REVIEWS

Evidence of Diminished Glucose Stimulation and Endoplasmic Reticulum Function in Nonoscillatory Pancreatic Islets

(2008) Pooya Jahanshahi et al.   ENDOCRINOLOGY

Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis

(2008) Xiuli Men et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The GK rat beta-cell: A prototype for the diseased human beta-cell in type 2 diabetes?

(2008) B. Portha et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells

(2008) Shilpa Gandre-Babbe et al.   MOLECULAR BIOLOGY OF THE CELL

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

(2008) M. Saotome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expedited approaches to whole cell electron tomography and organelle mark-up in situ in high-pressure frozen pancreatic islets

(2007) Andrew B. Noske et al.   JOURNAL OF STRUCTURAL BIOLOGY