A Two-Phase Approach Optimizing Productivity for a mAb-producing CHO Cell Culture Process Using Dynamic Response Surface Methodology Models

Hybrid Models Based on Machine Learning and an Increasing Degree of Process Knowledge: Application to Cell Culture Processes

(2022) Harini Narayanan et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Osmolality Effects on CHO Cell Growth, Cell Volume, Antibody Productivity and Glycosylation

(2021) Sakhr Alhuthali et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Optimization of pharmaceutical reactions using the dynamic response surface methodology

(2020) Yachao Dong et al.   COMPUTERS & CHEMICAL ENGINEERING

Characterization of the acidic species of a monoclonal antibody using free flow electrophoresis fractionation and mass spectrometry

(2020) Suli Liu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Upstream development of Escherichia coli fermentation process with PhoA promoter using design of experiments (DoE)

(2020) Frank K. Agbogbo et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Case study: The characterization and implementation of dielectric spectroscopy (biocapacitance) for process control in a commercial GMP CHO manufacturing process

(2019) Brandon Moore et al.   BIOTECHNOLOGY PROGRESS

Constrained Version of the Dynamic Response Surface Methodology for Modeling Pharmaceutical Reactions

(2019) Yachao Dong et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Industrial bioprocessing perspectives on managing therapeutic protein charge variant profiles

(2018) Stanley Chung et al.   BIOTECHNOLOGY AND BIOENGINEERING

Characterization of cellular states of CHO-K1 suspension cell culture through cell cycle and RNA-sequencing profiling

(2018) Ileana Tossolini et al.   JOURNAL OF BIOTECHNOLOGY

New Dynamic Response Surface Methodology for Modeling Nonlinear Processes over Semi-infinite Time Horizons

(2017) Zhenyu Wang et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Intensified design of experiments for upstream bioreactors

(2016) Moritz von Stosch et al.   ENGINEERING IN LIFE SCIENCES

Glycation of polyclonal IgGs: Effect of sugar excipients during stability studies

(2016) Y. Leblanc et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Dynamic Response Surface Models: A Data-Driven Approach for the Analysis of Time-Varying Process Outputs

(2016) Nikolai Klebanov et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Advanced process monitoring and feedback control to enhance cell culture process production and robustness

(2015) An Zhang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

(2014) Yuzhou Fan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Investigation of metabolic variability observed in extended fed batch cell culture

(2013) Alan Gilbert et al.   BIOTECHNOLOGY PROGRESS

Design of Dynamic Experiments: A Data-Driven Methodology for the Optimization of Time-Varying Processes

(2013) Christos Georgakis   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Analysis of dynamic changes in the proteome of a Bcl-XL overexpressing Chinese hamster ovary cell culture during exponential and stationary phases

(2012) Tyler Carlage et al.   BIOTECHNOLOGY PROGRESS

High Throughput Profiling of Charge Heterogeneity in Antibodies by Microchip Electrophoresis

(2011) Hongling Han et al.   ANALYTICAL CHEMISTRY

Genomics in mammalian cell culture bioprocessing

(2011) Diane M. Wuest et al.   BIOTECHNOLOGY ADVANCES

Towards dynamic metabolic flux analysis in CHO cell cultures

(2011) Woo Suk Ahn et al.   Biotechnology Journal

Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics

(2010) C. Andrew Boswell et al.   BIOCONJUGATE CHEMISTRY

Profiling of N-glycosylation gene expression in CHO cell fed-batch cultures

(2010) Danny Chee Furng Wong et al.   BIOTECHNOLOGY AND BIOENGINEERING

Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

(2010) Yao-Ming Huang et al.   BIOTECHNOLOGY PROGRESS

Charge variants in IgG1

(2010) Leslie A. Khawli et al.   mAbs

Characterization of a Monoclonal Antibody Cell Culture Production Process Using a Quality by Design Approach

(2010) Brian Horvath et al.   MOLECULAR BIOTECHNOLOGY

A predictive high-throughput scale-down model of monoclonal antibody production in CHO cells

(2009) Rachel Legmann et al.   BIOTECHNOLOGY AND BIOENGINEERING

Hyperosmotic stress induces autophagy and apoptosis in recombinant Chinese hamster ovary cell culture

(2009) Young Kue Han et al.   BIOTECHNOLOGY AND BIOENGINEERING