Hybrid Models Based on Machine Learning and an Increasing Degree of Process Knowledge: Application to Cell Culture Processes

Machine Learning for Biologics: Opportunities for Protein Engineering, Developability, and Formulation

(2021) Harini Narayanan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

In‐silico media optimization for continuous cultures using genome scale metabolic networks: The case of CHO‐K1

(2021) Bárbara A. Pérez‐Fernández et al.   BIOTECHNOLOGY AND BIOENGINEERING

Knowledge transfer across cell lines using hybrid Gaussian process models with entity embedding vectors

(2021) Clemens Hutter et al.   BIOTECHNOLOGY AND BIOENGINEERING

Hybrid Models Based on Machine Learning and an Increasing Degree of Process Knowledge: Application to Capture Chromatographic Step

(2021) Harini Narayanan et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Systematic evaluation of parameters for genome-scale metabolic models of cultured mammalian cells

(2021) Song-Min Schinn et al.   METABOLIC ENGINEERING

Functional-Hybrid modeling through automated adaptive symbolic regression for interpretable mathematical expressions

(2021) Harini Narayanan et al.   CHEMICAL ENGINEERING JOURNAL

Integration and digitalization in the manufacturing of therapeutic proteins

(2021) Harini Narayanan et al.   CHEMICAL ENGINEERING SCIENCE

Hybrid modeling — a key enabler towards realizing digital twins in biopharma?

(2021) Michael Sokolov et al.   Current Opinion in Chemical Engineering

Hybrid‐EKF: Hybrid Model coupled with Extended Kalman Filter for real‐time monitoring and control of mammalian cell culture

(2020) Harini Narayanan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Dynamic Modeling of CHO Cell Metabolism Using the Hybrid Cybernetic Approach With a Novel Elementary Mode Analysis Strategy

(2020) Juan A. Martínez et al.   Frontiers in Bioengineering and Biotechnology

Decision Making and Risk Management in Biopharmaceutical Engineering—Opportunities in the Age of Covid-19 and Digitalization

(2020) Michael Sokolov   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Decision Tree‐PLS (DT‐PLS) algorithm for the development of process: Specific local prediction models

(2019) Harini Narayanan et al.   BIOTECHNOLOGY PROGRESS

A hybrid modeling approach integrating first principles models with subspace identification

(2019) Debanjan Ghosh et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

A new generation of predictive models: The added value of hybrid models for manufacturing processes of therapeutic proteins

(2019) Harini Narayanan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Bioprocessing in the Digital Age: The Role of Process Models

(2019) Harini Narayanan et al.   Biotechnology Journal

Applications of hybrid models in chemical, petroleum, and energy systems: A systematic review

(2018) Sohrab Zendehboudi et al.   APPLIED ENERGY

Hybrid models for chemical reaction networks: Multiscale theory and application to gene regulatory systems

(2017) Stefanie Winkelmann et al.   JOURNAL OF CHEMICAL PHYSICS

A Systematic Evaluation of Methods for Tailoring Genome-Scale Metabolic Models

(2017) Sjoerd Opdam et al.   Cell Systems

What can mathematical modelling say about CHO metabolism and protein glycosylation?

(2017) Sarah N. Galleguillos et al.   Computational and Structural Biotechnology Journal

Hybrid modeling as a QbD/PAT tool in process development: an industrial E. coli case study

(2016) Moritz von Stosch et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Fingerprint detection and process prediction by multivariate analysis of fed-batch monoclonal antibody cell culture data

(2015) Michael Sokolov et al.   BIOTECHNOLOGY PROGRESS

Real time optimization based on a serial hybrid model for gold cyanidation leaching process

(2015) Jun Zhang et al.   MINERALS ENGINEERING

Hybrid modeling for quality by design and PAT-benefits and challenges of applications in biopharmaceutical industry

(2014) Moritz von Stosch et al.   Biotechnology Journal

Process model comparison and transferability across bioreactor scales and modes of operation for a mammalian cell bioprocess

(2012) Stephen Craven et al.   BIOTECHNOLOGY PROGRESS

Application of Quality by Design to the characterization of the cell culture process of an Fc-Fusion protein

(2012) Yolande Rouiller et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Process analytical technology (PAT) for biopharmaceuticals

(2011) Jarka Glassey et al.   Biotechnology Journal

Hybrid modeling framework for process analytical technology: Application to Bordetella pertussis cultures

(2011) M. von Stosch et al.   BIOTECHNOLOGY PROGRESS

Hybrid modeling for the prediction of leaching rate in leaching process based on negative correlation learning bagging ensemble algorithm

(2011) Guanghao Hu et al.   COMPUTERS & CHEMICAL ENGINEERING

A novel identification method for hybrid (N)PLS dynamical systems with application to bioprocesses

(2011) M. von Stosch et al.   EXPERT SYSTEMS WITH APPLICATIONS

Identification of semi-parametric hybrid process models

(2010) Aidong Yang et al.   COMPUTERS & CHEMICAL ENGINEERING

Modeling kinetics of a large-scale fed-batch CHO cell culture by Markov chain Monte Carlo method

(2009) Zizhuo Xing et al.   BIOTECHNOLOGY PROGRESS

A Hybrid Model Framework for the Optimization of Preparative Chromatographic Processes

(2004) Deepak Nagrath et al.   BIOTECHNOLOGY PROGRESS