Investigation of metabolic variability observed in extended fed batch cell culture

Generation of a cholesterol-independent, non-GS NS0 cell line through chemical treatment and application for high titer antibody production

(2012) Jincai Li et al.   BIOTECHNOLOGY AND BIOENGINEERING

Controlling trisulfide modification in recombinant monoclonal antibody produced in fed-batch cell culture

(2012) Rashmi Kshirsagar et al.   BIOTECHNOLOGY AND BIOENGINEERING

Towards dynamic metabolic flux analysis in CHO cell cultures

(2011) Woo Suk Ahn et al.   Biotechnology Journal

Estimating cell specific oxygen uptake and carbon dioxide production rates for mammalian cells in perfusion culture

(2011) Chetan T. Goudar et al.   BIOTECHNOLOGY PROGRESS

Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry

(2011) Woo Suk Ahn et al.   METABOLIC ENGINEERING

Identification of Metabolites in the Normal Ovary and Their Transformation in Primary and Metastatic Ovarian Cancer

(2011) Miranda Y. Fong et al.   PLoS One

Towards quantitative metabolomics of mammalian cells: Development of a metabolite extraction protocol

(2010) Stefanie Dietmair et al.   ANALYTICAL BIOCHEMISTRY

Gene amplification and vector engineering to achieve rapid and high-level therapeutic protein production using the Dhfr-based CHO cell selection system

(2010) Jonathan J. Cacciatore et al.   BIOTECHNOLOGY ADVANCES

Metabolic flux analysis of CHO cell metabolism in the late non-growth phase

(2010) Neelanjan Sengupta et al.   BIOTECHNOLOGY AND BIOENGINEERING

Understanding the intracellular effect of enhanced nutrient feeding toward high titer antibody production process

(2010) Marcella Yu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

(2010) Yao-Ming Huang et al.   BIOTECHNOLOGY PROGRESS

Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited

(2010) Alexei Vazquez et al.   BMC Systems Biology

Optimization of chemically defined cell culture media – Replacing fetal bovine serum in mammalian in vitro methods

(2010) J. van der Valk et al.   TOXICOLOGY IN VITRO

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism

(2009) Ningning Ma et al.   BIOTECHNOLOGY PROGRESS

Automation of cell line development

(2009) Kristina Lindgren et al.   CYTOTECHNOLOGY

Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells

(2009) Christian M. Metallo et al.   JOURNAL OF BIOTECHNOLOGY

Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopy

(2009) Chetan Goudar et al.   METABOLIC ENGINEERING

Enhancement of transient gene expression and culture viability using Chinese hamster ovary cells overexpressing Bcl-xL

(2008) Brian S. Majors et al.   BIOTECHNOLOGY AND BIOENGINEERING