Current Knowledge About the Impact of Maternal and Infant Nutrition on the Development of the Microbiota–Gut–Brain Axis

The microbiota–gut–brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice

(2022) Anirikh Chakrabarti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oligosaccharide and Flavanoid Mediated Prebiotic Interventions to Treat Gut Dysbiosis Associated Cognitive Decline

(2022) Suparna Roy Sarkar et al.   Journal of Neuroimmune Pharmacology

The resistance within: Antibiotic disruption of the gut microbiome and resistome dynamics in infancy

(2022) Robert Thänert et al.   Cell Host & Microbe

A synbiotics, long chain polyunsaturated fatty acids, and milk fat globule membranes supplemented formula modulates microbiota maturation and neurodevelopment closer to breastfed infants

(2022) Tomás Cerdó et al.   CLINICAL NUTRITION

Short chain fatty acids: Microbial metabolites for gut-brain axis signalling

(2022) Kenneth J. O'Riordan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Supplementation with milk fat globule membrane from early life reduces maternal separation-induced visceral pain independent of enteric nervous system or intestinal permeability changes in the rat

(2022) James M. Collins et al.   NEUROPHARMACOLOGY

Microbiota–brain axis: Context and causality

(2022) John F. Cryan et al.   SCIENCE

Pathways of atopic disease and neurodevelopmental impairment: assessing the evidence for infant antibiotics

(2022) Elizabeth Volker et al.   Expert Review of Clinical Immunology

The impact of maternal high-fat diet on offspring neurodevelopment

(2022) Gintare Urbonaite et al.   Frontiers in Neuroscience

A maternal higher-complex carbohydrate diet increases bifidobacteria and alters early life acquisition of the infant microbiome in women with gestational diabetes mellitus

(2022) Kameron Y. Sugino et al.   Frontiers in Endocrinology

Lactobacillus plantarum-derived postbiotics prevent Salmonella-induced neurological dysfunctions by modulating gut–brain axis in mice

(2022) Yanping Wu et al.   Frontiers in Nutrition

Milk fat globule membrane supplementation to obese rats during pregnancy and lactation promotes neurodevelopment in offspring via modulating gut microbiota

(2022) Qichen Yuan et al.   Frontiers in Nutrition

Probiotics and prebiotics alleviate behavioral deficits, inflammatory response, and gut dysbiosis in prenatal VPA-induced rodent model of autism

(2022) Emre Adıgüzel et al.   PHYSIOLOGY & BEHAVIOR

Randomized Double-Blind Crossover Study for Evaluating a Probiotic Mixture on Gastrointestinal and Behavioral Symptoms of Autistic Children

(2022) Cristina Guidetti et al.   Journal of Clinical Medicine

The Microbiota-Gut-Brain Axis: From Motility to Mood

(2021) Kara G. Margolis et al.   GASTROENTEROLOGY

Effects of Taraxacum and Astragalus extracts combined with probiotic Bacillus subtilis and Lactobacillus on Escherichia coli-infected broiler chickens

(2021) Wanfeng Liang et al.   POULTRY SCIENCE

Antibiotics and the developing intestinal microbiome, metabolome and inflammatory environment in a randomized trial of preterm infants

(2021) Jordan T. Russell et al.   Scientific Reports

A cross-talk between gut microbiome, salt and hypertension

(2021) Salma Naqvi et al.   BIOMEDICINE & PHARMACOTHERAPY

Priming for Life: Early Life Nutrition and the Microbiota-Gut-Brain Axis

(2021) Anna Ratsika et al.   Nutrients

Diet-induced dysbiosis of the maternal gut microbiome in early life programming of neurodevelopmental disorders

(2021) Claudia M. Di Gesù et al.   NEUROSCIENCE RESEARCH

Antibiotics at birth and later antibiotic courses: effects on gut microbiota

(2021) Sofia Ainonen et al.   PEDIATRIC RESEARCH

Perinatal Dietary Polyunsaturated Fatty Acids in Brain Development, Role in Neurodevelopmental Disorders

(2021) Maud Martinat et al.   Nutrients

Altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice

(2021) Kazi Farhana Afroz et al.   Scientific Reports

Safety and Tolerance of a Novel Anti-Regurgitation Formula

(2021) Marc Bellaiche et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Perinatal High-Salt Diet Induces Gut Microbiota Dysbiosis, Bile Acid Homeostasis Disbalance, and NAFLD in Weanling Mice Offspring

(2021) Qing Guo et al.   Nutrients

Early-life gut microbiota and its connection to metabolic health in children: Perspective on ecological drivers and need for quantitative approach

(2021) Ching Jian et al.   EBioMedicine

Protective Effects of Probiotics on Cognitive and Motor Functions, Anxiety Level, Visceral Sensitivity, Oxidative Stress and Microbiota in Mice with Antibiotic-Induced Dysbiosis

(2021) Alisa Arslanova et al.   Life-Basel

The regulatory roles of dietary fibers on host health via gut microbiota-derived short chain fatty acids

(2021) Tong Xu et al.   CURRENT OPINION IN PHARMACOLOGY

Increased efficacy of combining prebiotic and postbiotic in mouse models relevant to autism and depression

(2021) Antonio Leo et al.   NEUROPHARMACOLOGY

Dietary Supplementation throughout Life with Non-Digestible Oligosaccharides and/or n-3 Poly-Unsaturated Fatty Acids in Healthy Mice Modulates the Gut–Immune System–Brain Axis

(2021) Kirsten Szklany et al.   Nutrients

Molecular mechanisms of probiotic prevention of antibiotic-associated diarrhea

(2020) Solomon A Mekonnen et al.   CURRENT OPINION IN BIOTECHNOLOGY

Impact of Clostridium Bacteria in Children with Autism Spectrum Disorder and Their Anthropometric Measurements

(2020) Wafaa A. Kandeel et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The Evolving Microbiome from Pregnancy to Early Infancy: A Comprehensive Review

(2020) María Dolores Mesa et al.   Nutrients

Synthetic Cassettes for pH-Mediated Sensing, Counting, and Containment

(2020) Finn Stirling et al.   Cell Reports

Milk fat globule membrane: The role of its various components in infant health and development

(2020) Lauren R Brink et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime

(2020) Q. Leyrolle et al.   NEUROPSYCHOPHARMACOLOGY

Developmental effects on sleep–wake patterns in infants receiving a cow’s milk-based infant formula with an added prebiotic blend: a Randomized Controlled Trial

(2020) John Colombo et al.   PEDIATRIC RESEARCH

Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder

(2020) Ying Wang et al.   PHARMACOLOGICAL RESEARCH

Prenatal exposure to the probiotic Lactococcus lactis decreases anxiety-like behavior and modulates cortical cytoarchitecture in a sex specific manner.

(2020) Natalia Surzenko et al.   PLoS One

Neurodevelopmental Disorders: From Genetics to Functional Pathways

(2020) Ilaria Parenti et al.   TRENDS IN NEUROSCIENCES

A Revolutionizing Approach to Autism Spectrum Disorder Using the Microbiome

(2020) Dinyadarshini Johnson et al.   Nutrients

Sex dependent effects of post-natal penicillin on brain, behavior and immune regulation are prevented by concurrent probiotic treatment

(2020) Marya Kayyal et al.   Scientific Reports

Gut-Brain Axis in the Early Postnatal Years of Life: A Developmental Perspective

(2020) Ankita Jena et al.   Frontiers in Integrative Neuroscience

Mom’s diet matters: Maternal prebiotic intake in mice reduces anxiety and alters brain gene expression and the fecal microbiome in offspring

(2020) Jenna C Hebert et al.   BRAIN BEHAVIOR AND IMMUNITY

The maternal microbiome modulates fetal neurodevelopment in mice

(2020) Helen E. Vuong et al.   NATURE

Understanding the impact of antibiotic perturbation on the human microbiome

(2020) D. J. Schwartz et al.   Genome Medicine

Effects of Probiotic Supplementation on Gastrointestinal, Sensory and Core Symptoms in Autism Spectrum Disorders: A Randomized Controlled Trial

(2020) Elisa Santocchi et al.   Frontiers in Psychiatry

A Partly Fermented Infant Formula with Postbiotics Including 3′-GL, Specific Oligosaccharides, 2′-FL, and Milk Fat Supports Adequate Growth, Is Safe and Well-Tolerated in Healthy Term Infants: A Double-Blind, Randomised, Controlled, Multi-Country Trial

(2020) Yvan Vandenplas et al.   Nutrients

Physiological Impact of Palm Olein or Palm Oil in Infant Formulas: A Review of Clinical Evidence

(2020) Maria Padial-Jaudenes et al.   Nutrients

Maternal diet alters human milk oligosaccharide composition with implications for the milk metagenome

(2020) Maxim D. Seferovic et al.   Scientific Reports

The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology

(2020) Andrina Rutsch et al.   Frontiers in Immunology

Exposure to antibiotics in the first 24 months of life and neurocognitive outcomes at 11 years of age

(2019) R. F. Slykerman et al.   PSYCHOPHARMACOLOGY

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

Postbiotics: facts and open questions. A position paper on the need for a consensus definition

(2019) M.C. Collado et al.   Beneficial Microbes

Maternal Microbiome and Metabolic Health Program Microbiome Development and Health of the Offspring

(2019) Marta Calatayud et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Breastfeeding and neurodevelopmental outcomes

(2018) Bernardo L. Horta et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

n–3 Fatty Acid Supplementation in Mothers, Preterm Infants, and Term Infants and Childhood Psychomotor and Visual Development: A Systematic Review and Meta-Analysis

(2018) Masha Shulkin et al.   JOURNAL OF NUTRITION

Probiotic treatment reduces the autistic-like excitation/inhibition imbalance in juvenile hamsters induced by orally administered propionic acid and clindamycin

(2018) Afaf El-Ansary et al.   METABOLIC BRAIN DISEASE

Early nutrition influences developmental myelination and cognition in infants and young children

(2018) Sean Deoni et al.   NEUROIMAGE

How do informal information sources influence women’s decision-making for birth? A meta-synthesis of qualitative studies

(2018) Ruth A. Sanders et al.   BMC Pregnancy and Childbirth

A Vegetarian Diet Is a Major Determinant of Gut Microbiota Composition in Early Pregnancy

(2018) Helen Barrett et al.   Nutrients

Effect of early probiotic supplementation on childhood cognition, behaviour and mood a randomised, placebo-controlled trial

(2018) R F Slykerman et al.   ACTA PAEDIATRICA

The epidemiology of obesity

(2018) Yu Chung Chooi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A prebiotic intervention study in children with autism spectrum disorders (ASDs)

(2018) Roberta Grimaldi et al.   Microbiome

Maternal Pre-pregnancy Body Mass Index and Gestational Weight Gain in Relation to Autism Spectrum Disorder and other Developmental Disorders in Offspring

(2018) Gayle C. Windham et al.   Autism Research

A Microbiota-Derived Bacteriocin Targets the Host to Confer Diarrhea Resistance in Early-Weaned Piglets

(2018) Jun Hu et al.   Cell Host & Microbe

Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

(2018) Martina Sgritta et al.   NEURON

Sialic Acid and Sialylated Oligosaccharide Supplementation during Lactation Improves Learning and Memory in Rats

(2018) Elena Oliveros et al.   Nutrients

Effect of Synbiotic on the Gut Microbiota of Cesarean Delivered Infants

(2017) Mei Chien Chua et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery

(2017) Derrick M Chu et al.   NATURE MEDICINE

The hypothalamic transcriptional response to stress is severely impaired in offspring exposed to adverse nutrition during gestation

(2017) N.M. Grissom et al.   NEUROSCIENCE

Nuevos ingredientes en fórmulas infantiles. Beneficios sanitarios y funcionales

(2017) M. Cristina De Almagro García   Nutricion Hospitalaria

Maternal pre-pregnancy obesity and neuropsychological development in pre-school children: a prospective cohort study

(2017) Maribel Casas et al.   PEDIATRIC RESEARCH

Neurodevelopment: The Impact of Nutrition and Inflammation During Early to Middle Childhood in Low-Resource Settings

(2017) Chandy C. John et al.   PEDIATRICS

Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior

(2017) Sophie Leclercq et al.   Nature Communications

Ontogenesis of the Gut Microbiota Composition in Healthy, Full-Term, Vaginally Born and Breast-Fed Infants over the First 3 Years of Life: A Quantitative Bird’s-Eye View

(2017) Ravinder Nagpal et al.   Frontiers in Microbiology

New evidences on the altered gut microbiota in autism spectrum disorders

(2017) Francesco Strati et al.   Microbiome

Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort

(2017) Cian J. Hill et al.   Microbiome

Gut to brain interaction in Autism Spectrum Disorders: a randomized controlled trial on the role of probiotics on clinical, biochemical and neurophysiological parameters

(2016) Elisa Santocchi et al.   BMC Psychiatry

Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring

(2016) Shelly A. Buffington et al.   CELL

Oral supplementation of 2′-fucosyllactose during lactation improves memory and learning in rats

(2016) Elena Oliveros et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Prebiotics and Bioactive Milk Fractions Affect Gut Development, Microbiota, and Neurotransmitter Expression in Piglets

(2016) Kirsten Berding et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect

(2016) Cesar G Victora et al.   LANCET

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

Maternal obesity and neurodevelopmental and psychiatric disorders in offspring

(2016) Andrea G. Edlow   PRENATAL DIAGNOSIS

Microbial Changes during Pregnancy, Birth, and Infancy

(2016) Meital Nuriel-Ohayon et al.   Frontiers in Microbiology

The prebiotics 3′Sialyllactose and 6′Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut–brain axis

(2015) Andrew J. Tarr et al.   BRAIN BEHAVIOR AND IMMUNITY

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

(2015) Fredrik Bäckhed et al.   Cell Host & Microbe

Dietary Isomers of Sialyllactose Increase Ganglioside Sialic Acid Concentrations in the Corpus Callosum and Cerebellum and Modulate the Colonic Microbiota of Formula-Fed Piglets

(2015) Sheila K Jacobi et al.   JOURNAL OF NUTRITION

Low and High Birth Weight and the Risk of Child Attention Problems

(2015) Nina H. van Mil et al.   JOURNAL OF PEDIATRICS

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial

(2015) Anna Pärtty et al.   PEDIATRIC RESEARCH

High-fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis

(2015) Clara V. Perani et al.   Scientific Reports

Structure and function of the healthy pre-adolescent pediatric gut microbiome

(2015) Emily B. Hollister et al.   Microbiome

Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial

(2014) Niklas Timby et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A Review of the Source and Function of Microbiota in Breast Milk

(2014) Alison Stuebe et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Can we define an infant’s need from the composition of human milk?

(2013) José Stam et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months

(2013) M. B. Azad et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

(2013) Elaine Y. Hsiao et al.   CELL

Intestinal microbiota influence the early postnatal development of the enteric nervous system

(2013) J. Collins et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Neurodevelopmental Outcome during the First Year of Life in Preterm Infants after Supplementation of a Prebiotic Mixture in the Neonatal Period: A Follow-Up Study

(2013) Natalie LeCouffe et al.   NEUROPEDIATRICS

Fecal Microbiota and Metabolome of Children with Autism and Pervasive Developmental Disorder Not Otherwise Specified

(2013) Maria De Angelis et al.   PLoS One

Development of intestinal microbiota in infants and its impact on health

(2013) Sebastien Matamoros et al.   TRENDS IN MICROBIOLOGY

Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy

(2012) Omry Koren et al.   CELL

Probiotics Modulate Host-Microbe Interaction in the Placenta and Fetal Gut: A Randomized, Double-Blind, Placebo-Controlled Trial

(2012) Samuli Rautava et al.   Neonatology

Nutritional Management of the Breastfeeding Dyad

(2012) Christina J. Valentine et al.   PEDIATRIC CLINICS OF NORTH AMERICA

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

(2011) Premysl Bercik et al.   GASTROENTEROLOGY

Shifting the balance: antibiotic effects on host–microbiota mutualism

(2011) Benjamin P. Willing et al.   NATURE REVIEWS MICROBIOLOGY

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of mother’s weight on infant’s microbiota acquisition, composition, and activity during early infancy: a prospective follow-up study initiated in early pregnancy

(2010) Maria Carmen Collado et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

High-resolution nuclear magnetic resonance spectroscopic study of metabolites in the cerebrospinal fluid of patients with cervical myelopathy and lumbar radiculopathy

(2010) Hideki Nagashima et al.   EUROPEAN SPINE JOURNAL

Gut???brain axis

(2008) Johannes A Romijn et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Antibiotic-associated diarrhea: epidemiology, trends and treatment

(2008) Lynne V McFarland   Future Microbiology