Review
Biology
Georgia Saxami, Evangelia N. Kerezoudi, Christos Eliopoulos, Dimitrios Arapoglou, Adamantini Kyriacou
Summary: The human gut microbiota plays a crucial role in maintaining body homeostasis and any deviation from the normal composition can lead to various diseases. There is limited evidence on the effects of prebiotics in restoring the gut microbiota balance.
Review
Biochemistry & Molecular Biology
Davide Banfi, Elisabetta Moro, Annalisa Bosi, Michela Bistoletti, Silvia Cerantola, Francesca Crema, Fabrizio Maggi, Maria Cecilia Giron, Cristina Giaroni, Andreina Baj
Summary: This article discusses the role of the microbiota-gut-brain axis in the pathogenesis of Inflammatory Bowel Disease (IBD) and the impact of microbial-derived metabolites on the development of IBD-related symptoms. It points out that mood disorders and heightened stress responses may affect the severity of IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Garvita Sharma, Shristi Saroj Biswas, Jayapriya Mishra, Umashanker Navik, Ramesh Kandimalla, P. Hemachandra Reddy, Gurjit Kaur Bhatti, Jasvinder Singh Bhatti
Summary: Huntington's disease (HD) is a complex neurodegenerative disorder influenced by genetic, environmental, and metabolic factors. Gut dysbiosis, the alteration of intestinal microbial profile, has been found to play a crucial role in HD pathophysiology through mechanisms such as neuroinflammation, immune system dysregulation, and altered metabolites composition. This review article provides an overview of the relationship between gut dysbiosis and HD, as well as future challenges and opportunities in therapeutics.
Review
Biochemistry & Molecular Biology
Jamie van Son, Laura L. Koekkoek, Susanne E. La Fleur, Mireille J. Serlie, Max Nieuwdorp
Summary: Obesity, a global epidemic, is associated with microbial dysbiosis. Research indicates that the gut microbiota and its metabolites have an impact on human brain and behavior. Future treatment strategies for obesity may target the gut microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Yasmina Ait Chait, Walid Mottawea, Thomas A. Tompkins, Riadh Hammami
Summary: Emerging evidence suggests that the microbiota-gut-brain axis plays an essential role in maintaining human homeostasis, with a particular focus on the bidirectional interplay between gut microbiota and the brain in psychiatric disorders. Attention has been drawn to the impact of psychotropic drugs on gut microbiota and the potential therapeutic strategies to alleviate dysbiosis associated with their intake.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Cardiac & Cardiovascular Systems
Pedram Honarpisheh, Robert M. Bryan, Louise D. McCullough
Summary: The microbiota-gut-brain-axis (MGBA) is a communication network between gut microbes and the host, and dysbiosis disrupts this network, affecting the host's immune, metabolic, and nervous systems. Dysbiosis is linked to aging and stroke, and is associated with stroke risk factors such as obesity and diabetes. The article summarizes the role of MGBA signaling in the development of stroke risk factors and discusses current understanding of microbiota-based therapies for stroke.
CIRCULATION RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Md. Rayhan Mahmud, Sharmin Akter, Sanjida Khanam Tamanna, Lincon Mazumder, Israt Zahan Esti, Sanchita Banerjee, Sumona Akter, Md. Rakibul Hasan, Mrityunjoy Acharjee, Md. Sajjad Hossain, Anna Maria Pirttila
Summary: This review systematically evaluates the impact of healthy skin and gut microbial ecology, diet, pre- and probiotics, and antibiotics on the gut microbiome and skin health, discussing potential mechanisms of the gut-skin axis and the link between gut and skin-associated diseases.
Review
Medicine, Research & Experimental
Ling Li, Jiahui Yang, Tianjing Liu, Yongyan Shi
Summary: Brain injury is a common complication in preterm infants, causing destruction of brain connections and leading to neurodevelopmental disorders with high morbidity and mortality rates. The role of intestinal flora in brain development and immune maturation in infants is important, but the understanding of the gut microbiota-metabolite-brain axis in preterm infants is limited. This review summarizes the mechanisms by which intestinal microbiota contribute to neurodevelopment and brain injury in preterm infants, emphasizing the influence of microorganisms and metabolites on neurocognitive development and neurodevelopmental risks associated with preterm birth, infection, and NEC. The review supports the development and application of therapeutic strategies such as probiotics, prebiotics, synbiotics, and fecal bacteria transplantation for brain injury in preterm infants.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Neurosciences
Hanif Ullah, Safia Arbab, Yali Tian, Chang-qing Liu, Yuwen Chen, Li Qijie, Muhammad Inayat Ullah Khan, Inam Ul Hassan, Ka Li
Summary: The gut microbiota has a significant impact on the host's physiology and pathology, communicating with different organs through hormone synthesis and regulation of body activity. Dysbiosis in the gut microbiota leads to gastrointestinal disorders that affect host physiology through abnormal microbial metabolites. This dysbiosis alters the bidirectional relationship between the central nervous system and gut microbiota, contributing to the pathogenesis of neurodevelopmental and neurological disorders. Increasing evidence suggests that gut microbes may play a role in the progression of neurological disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and autism spectrum disorder.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Nutrition & Dietetics
Jasmine Carter, Jeffery Bettag, Sylvia Morfin, Chandrashekhara Manithody, Aakash Nagarapu, Aditya Jain, Hala Nazzal, Sai Prem, Meghan Unes, Matthew McHale, Chien-Jung Lin, Chelsea Hutchinson, Grace Trello, Arti Jain, Edward Portz, Arun Verma, Marzena Swiderska-Syn, Daniel Goldenberg, Kento Kurashima
Summary: Short bowel syndrome (SBS) is a condition caused by a reduction in the length or functional capacity of the intestine. The gut microbiome plays a significant role in modulating disease progression in SBS patients. The composition and shifts of gut bacteria in SBS and the resulting systemic effects have been extensively studied, revealing the variability and dependence on multiple factors. The bidirectional communication between the gut and the brain, regulated by the microbiome, known as the gut-brain axis (GBA), also has implications in SBS.
Review
Agriculture, Dairy & Animal Science
Robert Ringseis, Klaus Eder
Summary: Heat stress is a major challenge for animal production, causing economic losses and reduced productivity, health, and welfare. Birds and pigs are particularly susceptible to heat stress due to their sweat glands. Gut dysbiosis, or disruption of the gut microbiota, occurs in broilers and pigs under heat stress, leading to a disruption of the gut barrier and endotoxemia. Feeding probiotics, prebiotics, and synbiotics has been shown to protect broilers from heat stress-induced gut barrier disruption and improve productivity, health, and welfare. Limited studies suggest that probiotics may also benefit pigs under heat stress.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Review
Peripheral Vascular Disease
Natalia G. Vallianou, Dimitris Kounatidis, Fotis Panagopoulos, Angelos Evangelopoulos, Vassilios Stamatopoulos, Anastasios Papagiorgos, Eleni Geladari, Maria Dalamaga
Summary: The review summarized recent findings on the mechanisms involved in hypertension related to gut dysbiosis. Gut dysbiosis, characterized by the imbalance between gut microbiota and the host, can increase gut permeability and lead to the accumulation of uremic toxins in the blood and urine, causing damage to the kidney. In addition, immunological mechanisms and the brain-gut-kidney axis are suggested to play important roles in hypertension.
CURRENT HYPERTENSION REPORTS
(2023)
Review
Nutrition & Dietetics
Yadong Zheng, Laura Bonfili, Tao Wei, Anna Maria Eleuteri
Summary: The gut-brain axis is a complex communication network between the gut and brain, involving neural, immune, and endocrine pathways. The gut microbiota plays an important role in this axis and its dysbiosis has been associated with neurodegenerative disorders. Manipulating the gut microbiota shows promise as a potential therapeutic target for these diseases.
Review
Biochemistry & Molecular Biology
Agata Chudzik, Anna Orzylowska, Radoslaw Rola, Greg J. Stanisz
Summary: The brain-gut-microbiome axis is a bidirectional communication pathway between the gut microbiota and the central nervous system. Studies have shown that certain probiotics can help alleviate symptoms of depression, and clinical trials have demonstrated improvements in mood and changes in biochemical parameters in patients with depressive disorders.
Review
Pharmacology & Pharmacy
Pilar Abiega-Franyutti, Veronica Freyre-Fonseca
Summary: This study reveals a clear link between food additives and changes in the gut microbiota that lead to various chronic diseases, yet research on the effects of food additives on microbiota is still inadequate, indicating a need for further investigation in this area.
Review
Immunology
Suparna Roy Sarkar, Sugato Banerjee
JOURNAL OF NEUROIMMUNOLOGY
(2019)
Article
Psychology, Biological
Suparna Roy Sarkar, Papiya Mitra Mazumder, Kaberi Chatterjee, Abhishek Sarkar, Maria Adhikary, Kunal Mukhopadhyay, Sugato Banerjee
Summary: The study demonstrates that Saccharomyces boulardii treatment can correct antibiotic-induced gut dysbiosis and cognitive decline by restoring gut microbiota and reducing brain inflammation and oxidative stress to protect neurons.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Immunology
Suparna Roy Sarkar, Papiya Mitra Mazumder, Sugato Banerjee
JOURNAL OF NEUROIMMUNOLOGY
(2020)