Cellular ageing mechanisms in osteoarthritis

Ageing is associated with reduction of mechanically-induced activation of Smad2/3P signaling in articular cartilage

(2016) W. Madej et al.   OSTEOARTHRITIS AND CARTILAGE

Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise

(2015) M. S. Brook et al.   Acta Physiologica

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

(2015) Faezeh Vasheghani et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis

(2015) Thibault Bouderlique et al.   ANNALS OF THE RHEUMATIC DISEASES

Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis

(2015) Maierhaba Ailixiding et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Role of Innate Immunity in Osteoarthritis: When Our First Line of Defense Goes On the Offensive

(2015) E. W. Orlowsky et al.   JOURNAL OF RHEUMATOLOGY

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development

(2015) Yaosen Wu et al.   Scientific Reports

Peroxisome Proliferator-Activated Receptor δ Promotes the Progression of Posttraumatic Osteoarthritis in a Mouse Model

(2015) A. Ratneswaran et al.   Arthritis & Rheumatology

The Relationship of Autophagy Defects to Cartilage Damage During Joint Aging in a Mouse Model

(2015) Beatriz Caramés et al.   Arthritis & Rheumatology

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

(2014) Yue Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

The Many Faces of Sirtuins: Coupling of NAD metabolism, sirtuins and lifespan

(2014) Eric Verdin   NATURE MEDICINE

Emerging regulators of the inflammatory process in osteoarthritis

(2014) Ru Liu-Bryan et al.   Nature Reviews Rheumatology

Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C/EBP homologous protein

(2014) Y. Uehara et al.   OSTEOARTHRITIS AND CARTILAGE

Sirtuins: guardians of mammalian healthspan

(2014) William Giblin et al.   TRENDS IN GENETICS

FoxO Transcription Factors Support Oxidative Stress Resistance in Human Chondrocytes

(2014) Yukio Akasaki et al.   Arthritis & Rheumatology

Adult Cartilage-Specific Peroxisome Proliferator–Activated Receptor Gamma Knockout Mice Exhibit the Spontaneous Osteoarthritis Phenotype

(2013) Faezeh Vasheghani et al.   AMERICAN JOURNAL OF PATHOLOGY

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

(2013) Tokio Matsuzaki et al.   ANNALS OF THE RHEUMATIC DISEASES

Calcium Flashes Orchestrate the Wound Inflammatory Response through DUOX Activation and Hydrogen Peroxide Release

(2013) William Razzell et al.   CURRENT BIOLOGY

Erratum: Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis

(2013) Y. Akasaki et al.   OSTEOARTHRITIS AND CARTILAGE

C/EBP homologous protein drives pro-catabolic responses in chondrocytes

(2013) Matt Husa et al.   ARTHRITIS RESEARCH & THERAPY

Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes

(2013) Freyr Petursson et al.   ARTHRITIS RESEARCH & THERAPY

Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice

(2012) Odile Gabay et al.   ANNALS OF THE RHEUMATIC DISEASES

Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model

(2012) Odile Gabay et al.   ARTHRITIS AND RHEUMATISM

Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo

(2012) Annika Burleigh et al.   ARTHRITIS AND RHEUMATISM

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Seven sirtuins for seven deadly diseases ofaging

(2012) Brian J. Morris   FREE RADICAL BIOLOGY AND MEDICINE

XBP1S Associates with RUNX2 and Regulates Chondrocyte Hypertrophy

(2012) Yanna Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α

(2011) Robert Terkeltaub et al.   ARTHRITIS AND RHEUMATISM

Lack of a chondroprotective effect of cyclooxygenase 2 inhibition in a surgically induced model of osteoarthritis in mice

(2011) Atsushi Fukai et al.   ARTHRITIS AND RHEUMATISM

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Aging and osteoarthritis

(2011) Richard F. Loeser   CURRENT OPINION IN RHEUMATOLOGY

Enhanced apoptotic and reduced protective response in chondrocytes following endoplasmic reticulum stress in osteoarthritic cartilage

(2011) Koji Takada et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA

(2011) Martin K. Lotz et al.   Nature Reviews Rheumatology

Peroxisome proliferator activated receptor alpha activation decreases inflammatory and destructive responses in osteoarthritic cartilage

(2011) S. Clockaerts et al.   OSTEOARTHRITIS AND CARTILAGE

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions

(2010) Norifumi Fujita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

SIRT1 regulation of apoptosis of human chondrocytes

(2009) Koji Takayama et al.   ARTHRITIS AND RHEUMATISM

Klotho and aging

(2009) Makoto Kuro-o   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Commentary: Is It Useful to Subset “Primary” Osteoarthritis? A Critique Based on Evidence Regarding the Etiopathogenesis of Osteoarthritis

(2009) Kenneth D. Brandt et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase

(2008) Mona Dvir-Ginzberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes Analyzed by Proteomics

(2008) Cristina Ruiz-Romero et al.   MOLECULAR & CELLULAR PROTEOMICS

The quantitative and functional relation between insulin-like growth factor-I (IGF) and IGF-binding proteins during human osteoarthritis

(2007) Teresa I. Morales   JOURNAL OF ORTHOPAEDIC RESEARCH