Drug repositioning in SLE: crowd-sourcing, literature-mining and Big Data analysis

The key culprit in the pathogenesis of systemic lupus erythematosus: Aberrant DNA methylation

(2016) Haijing Wu et al.   AUTOIMMUNITY REVIEWS

Biological effects of IL-21 on different immune cells and its role in autoimmune diseases

(2016) Tohid Gharibi et al.   IMMUNOBIOLOGY

Genetics and novel aspects of therapies in systemic lupus erythematosus

(2015) Manfred Relle et al.   AUTOIMMUNITY REVIEWS

Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases

(2015) Kunihiro Ichinose et al.   CLINICAL IMMUNOLOGY

Drug repositioning and repurposing: terminology and definitions in literature

(2015) Joris Langedijk et al.   DRUG DISCOVERY TODAY

Microarray to deep sequencing: transcriptome and miRNA profiling to elucidate molecular pathways in systemic lupus erythematosus

(2015) Geeta Rai et al.   IMMUNOLOGIC RESEARCH

The $2.6 Billion Pill — Methodologic and Policy Considerations

(2015) Jerry Avorn   NEW ENGLAND JOURNAL OF MEDICINE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

The Role of MicroRNAs and Human Epidermal Growth Factor Receptor 2 in Proliferative Lupus Nephritis

(2015) Patrícia Costa-Reis et al.   Arthritis & Rheumatology

Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus

(2015) Sharon A. Chung et al.   PLoS One

Advances in lupus genetics and epigenetics

(2014) Yun Deng et al.   CURRENT OPINION IN RHEUMATOLOGY

CANDO and the infinite drug discovery frontier

(2014) Mark Minie et al.   DRUG DISCOVERY TODAY

CD25+Bcl6lowT follicular helper cells provide help to maturing B cells in germinal centers of human tonsil

(2014) Haishan Li et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-17 Promotes Murine Lupus

(2014) Gil Amarilyo et al.   JOURNAL OF IMMUNOLOGY

Cell-Specific Type I IFN Signatures in Autoimmunity and Viral Infection: What Makes the Difference?

(2014) Chieko Kyogoku et al.   PLoS One

Chance, genetics, and the heterogeneity of disease and pathogenesis in systemic lupus erythematosus

(2014) Tony N. Marion et al.   Seminars in Immunopathology

A comprehensive approach to identify approved drugs and treatments for repositioning as therapies for systemic lupus erythematosus

(2014) Amrie C Grammer et al.   ARTHRITIS RESEARCH & THERAPY

Modular Transcriptional Repertoire Analyses of Adults With Systemic Lupus Erythematosus Reveal Distinct Type I and Type II Interferon Signatures

(2014) Laurent Chiche et al.   Arthritis & Rheumatology

Interleukin-21 Promotes Germinal Center Reaction by Skewing the Follicular Regulatory T Cell to Follicular Helper T Cell Balance in Autoimmune BXD2 Mice

(2014) Yanna Ding et al.   Arthritis & Rheumatology

Computational Drug Repositioning: From Data to Therapeutics

(2013) M R Hurle et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Dominant Th1 and Minimal Th17 Skewing in Discoid Lupus Revealed by Transcriptomic Comparison with Psoriasis

(2013) Ali Jabbari et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Interleukin-17 Expression Positively Correlates with Disease Severity of Lupus Nephritis by Increasing Anti-Double-Stranded DNA Antibody Production in a Lupus Model Induced by Activated Lymphocyte Derived DNA

(2013) Zhenke Wen et al.   PLoS One

T Follicular Helper Cells Mediate Expansion of Regulatory B Cells via IL-21 in Lupus-Prone MRL/lpr Mice

(2013) Xue Yang et al.   PLoS One

Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α-kinoid

(2012) Bernard R. Lauwerys et al.   ARTHRITIS AND RHEUMATISM

Investigating drug repositioning opportunities in FDA drug labels through topic modeling

(2012) Halil Bisgin et al.   BMC BIOINFORMATICS

Cross-Species Transcriptional Network Analysis Defines Shared Inflammatory Responses in Murine and Human Lupus Nephritis

(2012) C. C. Berthier et al.   JOURNAL OF IMMUNOLOGY

IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Faslpr/lpr/J Mice

(2012) A. L. Rankin et al.   JOURNAL OF IMMUNOLOGY

The multifaceted balance of TNF-α and type I/II interferon responses in SLE and RA: how monocytes manage the impact of cytokines

(2012) Biljana Smiljanovic et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Molecular Characterization of Circulating Plasma Cells in Patients with Active Systemic Lupus Erythematosus

(2012) Patricia L. Lugar et al.   PLoS One

Inhibition of Aberrant Circulating Tfh Cell Proportions by Corticosteroids in Patients with Systemic Lupus Erythematosus

(2012) Xuebing Feng et al.   PLoS One

Successful Treatment of Subacute Lupus Erythematosus With Ustekinumab

(2011) Aieska De Souza   ARCHIVES OF DERMATOLOGY

Comparison study of microarray meta-analysis methods

(2010) Anna Campain et al.   BMC BIOINFORMATICS

In vitro potency, pharmacokinetic profiles and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus

(2010) Yulia Vugmeyster et al.   mAbs

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Key Issues in Conducting a Meta-Analysis of Gene Expression Microarray Datasets

(2008) Adaikalavan Ramasamy et al.   PLOS MEDICINE