Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

Yin Yang 1 Deficiency in Skeletal Muscle Protects against Rapamycin-Induced Diabetic-like Symptoms through Activation of Insulin/IGF Signaling

(2012) Sharon M. Blättler et al.   Cell Metabolism

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

(2012) Zheng Sun et al.   NATURE MEDICINE

Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders

(2012) D. Fukuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

Impaired Generation of 12-Hydroxylated Bile Acids Links Hepatic Insulin Signaling with Dyslipidemia

(2011) Rebecca A. Haeusler et al.   Cell Metabolism

Hepatic FoxOs Regulate Lipid Metabolism via Modulation of Expression of the Nicotinamide Phosphoribosyltransferase Gene

(2011) Rongya Tao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of antisense-mediated inhibition of 11β-hydroxysteroid dehydrogenase type 1 on hepatic lipid metabolism

(2011) Guoping Li et al.   JOURNAL OF LIPID RESEARCH

Health and economic burden of the projected obesity trends in the USA and the UK

(2011) Y Claire Wang et al.   LANCET

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

(2011) Utpal B Pajvani et al.   NATURE MEDICINE

Selective Insulin Sensitizers

(2011) J. Y. Kim-Muller et al.   SCIENCE

Wnt Signaling Regulates Hepatic Metabolism

(2011) H. Liu et al.   Science Signaling

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

(2011) Jessica J. Howell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Downregulation of Notch Pathway by a  -Secretase Inhibitor Attenuates AKT/Mammalian Target of Rapamycin Signaling and Glucose Uptake in an ERBB2 Transgenic Breast Cancer Model

(2010) C. L. Efferson et al.   CANCER RESEARCH

Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance

(2010) David B Savage et al.   CURRENT OPINION IN LIPIDOLOGY

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

FoxOs Function Synergistically to Promote Glucose Production

(2010) Rebecca A. Haeusler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly

(2010) Takeshi Kaizuka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

(2010) Shijie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

(2009) Mark E. Fortini   DEVELOPMENTAL CELL

Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser863and Multisite Phosphorylation

(2009) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Notch1 Ectodomain Construct Inhibits Endothelial Notch Signaling, Tumor Growth, and Angiogenesis

(2008) Y. Funahashi et al.   CANCER RESEARCH

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

(2008) Catherine Postic et al.   JOURNAL OF CLINICAL INVESTIGATION

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Rational targeting of Notch signaling in cancer

(2008) P Rizzo et al.   ONCOGENE

Notch signaling regulates tumor angiogenesis by diverse mechanisms

(2008) J Dufraine et al.   ONCOGENE