Osteopontin as a Biomarker in Chronic Kidney Disease

Therapeutic Advances in Diabetic Nephropathy

(2022) Hanny Sawaf et al.   Journal of Clinical Medicine

Association of Osteopontin gene single nucleotide polymorphism with lupus nephritis

(2022) R. M. Metwally et al.   International Journal of Rheumatic Diseases

Molecular Mechanisms and Therapeutic Targets for Diabetic Kidney Disease

(2022) Katherine R. Tuttle et al.   KIDNEY INTERNATIONAL

Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study

(2022) Inga Steinbrenner et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Genetics of osteopontin in patients with chronic kidney disease: The German Chronic Kidney Disease study

(2022) Yurong Cheng et al.   PLoS Genetics

Osteopontin—A Potential Biomarker for IgA Nephropathy: Machine Learning Application

(2022) Barbara Moszczuk et al.   Biomedicines

Serum Osteopontin Level Is Positively Associated with Aortic Stiffness in Patients with Peritoneal Dialysis

(2022) Kai-Hsiang Chang et al.   Life-Basel

Vitamin D3 Repletion Improves Vascular Function, as Measured by Cardiorenal Biomarkers in a High-Risk African American Cohort

(2022) Satyesh K. Sinha et al.   Nutrients

Cell Cycle Regulation by Integrin-Mediated Adhesion

(2022) Siamak A. Kamranvar et al.   Cells

The Role of Osteopontin in Tumor Progression Through Tumor-Associated Macrophages

(2022) Yuying Tan et al.   Frontiers in Oncology

Renoprotective Mechanism of Sodium-Glucose Cotransporter 2 Inhibitors: Focusing on Renal Hemodynamics

(2022) Nam Hoon Kim et al.   Diabetes & Metabolism Journal

Diabetic Kidney Disease Back in Focus: Management Field Guide for Health Care Professionals in the 21st Century

(2022) Radica Alicic et al.   MAYO CLINIC PROCEEDINGS

Effective delivery of osteopontin small interference RNA using exosomes suppresses liver fibrosis via TGF-β1 signaling

(2022) Min Tang et al.   Frontiers in Pharmacology

Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells

(2022) Mohammad Kamalabadi-Farahani et al.   BMC Research Notes

Osteopontin isoform c promotes the survival of cisplatin-treated NSCLC cells involving NFATc2-mediated suppression on calcium-induced ROS levels

(2021) Jing Huang et al.   BMC CANCER

Plasmatic osteopontin and vascular access dysfunction in hemodialysis patients: a cross-sectional, case–control study (The OSMOSIS Study)

(2021) Julie Contenti et al.   JOURNAL OF NEPHROLOGY

Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019

(2021) Yujiao Deng et al.   Frontiers in Endocrinology

Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice

(2021) Hongyang Liu et al.   Frontiers in Cell and Developmental Biology

Regulatory roles of osteopontin in human lung cancer cell epithelial‐to‐mesenchymal transitions and responses

(2021) Lin Shi et al.   Clinical and Translational Medicine

Both Full-Length and Protease-Cleaved Products of Osteopontin Are Elevated in Infectious Diseases

(2021) Toshio Hattori et al.   Biomedicines

Incidence and risk factors for mortality and end-stage renal disease in people with type 2 diabetes and diabetic kidney disease: a population-based cohort study in the UK

(2021) Antonio González-Pérez et al.   BMJ Open Diabetes Research & Care

Syndecan‐4 Protects the Heart From the Profibrotic Effects of Thrombin‐Cleaved Osteopontin

(2020) Kate M. Herum et al.   Journal of the American Heart Association

Osteopontin in Bone Metabolism and Bone Diseases

(2020) Jinyan Si et al.   MEDICAL SCIENCE MONITOR

Circulating Tumor Necrosis Factor Receptors: A Potential Biomarker for the Progression of Diabetic Kidney Disease

(2020) Maki Murakoshi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparison of bias and accuracy using cystatin C and creatinine in CKD-EPI equations for GFR estimation

(2020) Lu-Xi Zou et al.   European Journal of Internal Medicine

Plasma Osteopontin Levels is Associated with Biochemical Markers of Kidney Injury in Patients with Leptospirosis

(2020) Haorile Chagan-Yasutan et al.   Diagnostics

IgA nephropathy: An interesting autoimmune kidney disease

(2020) Arun Rajasekaran et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Abnormally activated OPN/integrin αVβ3/FAK signalling is responsible for EGFR-TKI resistance in EGFR mutant non-small-cell lung cancer

(2020) Yulong Fu et al.   Journal of Hematology & Oncology

Osteopontin: A Key Regulator of Tumor Progression and Immunomodulation

(2020) Hannah R. Moorman et al.   Cancers

Osteopontin and Disease Activity in Patients with Recent-onset Systemic Lupus Erythematosus: Results from the SLICC Inception Cohort

(2019) Lina Wirestam et al.   JOURNAL OF RHEUMATOLOGY

Osteopontin plays important roles in pulmonary arterial hypertension induced by systemic-to-pulmonary shunt

(2019) Liukun Meng et al.   FASEB JOURNAL

Osteopontin in Vascular Disease

(2019) Zoe Shin Yee Lok et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial injury is closely related to osteopontin and TNF receptor-mediated inflammation in end-stage renal disease

(2019) Krzysztof Batko et al.   CYTOKINE

Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight

(2019) Anne-Sophie Lamort et al.   Cells

Diabetic kidney diseases revisited: A new perspective for a new era

(2019) Haiyan Fu et al.   Molecular Metabolism

Copeptin Plasma Levels are Associated With Decline of Renal Function in Patients With Type 2 Diabetes Mellitus

(2018) Maria De La Luz Villela-Torres et al.   ARCHIVES OF MEDICAL RESEARCH

Biological role of site-specific O-glycosylation in cell adhesion activity and phosphorylation of osteopontin

(2018) Midori Oyama et al.   BIOCHEMICAL JOURNAL

The multiple functions and mechanisms of osteopontin

(2018) Mehmet Arif Icer et al.   CLINICAL BIOCHEMISTRY

Biomarkers of diabetic kidney disease

(2018) Helen M. Colhoun et al.   DIABETOLOGIA

Osteopontin isoforms differentially promote arteriogenesis in response to ischemia via macrophage accumulation and survival

(2018) Grace Sanghee Lee et al.   LABORATORY INVESTIGATION

The role of osteopontin in the progression of solid organ tumour

(2018) Hailin Zhao et al.   Cell Death & Disease

The role of osteopontin in kidney diseases

(2018) Beata Kaleta   INFLAMMATION RESEARCH

Thrombin cleavage of osteopontin controls activation of hepatic stellate cells and is essential for liver fibrogenesis

(2018) Guangying Cui et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypoxia-driven paracrine osteopontin/integrin αvβ3 signaling promotes pancreatic cancer cell epithelial-mesenchymal transition and cancer stem cell-like properties by modulating forkhead box protein M1

(2018) Junyu Cao et al.   Molecular Oncology

Intensified multifactorial intervention in type 2 diabetics with microalbuminuria leads to long-term renal benefits

(2017) Jens Oellgaard et al.   KIDNEY INTERNATIONAL

Membranous nephropathy: integrating basic science into improved clinical management

(2017) Daniel C. Cattran et al.   KIDNEY INTERNATIONAL

Membranous nephropathy—one morphologic pattern with different diseases

(2017) Elion Hoxha et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin α v β 3 /FAK/AKT Pathway SuppressionCLINICAL PERSPECTIVE

(2017) Daile Jia et al.   Circulation-Cardiovascular Genetics

Osteopontin -- a promising biomarker for cancer therapy

(2017) Ran Wei et al.   Journal of Cancer

A novel small-molecule PPI inhibitor targeting integrin αvβ3-osteopontin interface blocks bone resorption in vitro and prevents bone loss in mice

(2016) Doori Park et al.   BIOMATERIALS

Comparison of cystatin C- and creatinine-based estimated glomerular filtration rates for predicting all-cause mortality in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry

(2016) Hitoshi Ide et al.   Clinical and Experimental Nephrology

Serum amyloid a and risk of death and end-stage renal disease in diabetic kidney disease

(2016) Brad P. Dieter et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

An autopsy study suggests that diabetic nephropathy is underdiagnosed

(2016) Celine Q.F. Klessens et al.   KIDNEY INTERNATIONAL

Intrarenal macrophage infiltration induced by T cells is associated with podocyte injury in lupus nephritis patients

(2016) R Ma et al.   LUPUS

Renal outcomes in mixed proliferative and membranous lupus nephritis (Class III/IV + V): A long-term observational study

(2016) Hidekazu Ikeuchi et al.   Modern Rheumatology

Cleaved Form of Osteopontin in Urine as a Clinical Marker of Lupus Nephritis

(2016) Koji Kitagori et al.   PLoS One

Rat Urinary Osteopontin and Neutrophil Gelatinase-Associated Lipocalin Improve Certainty of Detecting Drug-Induced Kidney Injury

(2016) Jonathan A. Phillips et al.   TOXICOLOGICAL SCIENCES

Thrombin Cleavage of Osteopontin Modulates Its Activities in Human CellsIn Vitroand Mouse Experimental Autoimmune EncephalomyelitisIn Vivo

(2016) Elena Boggio et al.   Journal of Immunology Research

SVVYGLR motif of the thrombin-cleaved N-terminal osteopontin fragment enhances the synthesis of collagen type III in myocardial fibrosis

(2015) Ayako Uchinaka et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Role of osteopontin in the regulation of human bladder cancer proliferation and migration in T24 cells

(2015) SONG-TAO XU et al.   Molecular Medicine Reports

Role of Osteopontin in Systemic Lupus Erythematosus

(2014) Beata Kaleta   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Osteopontin Knockdown Inhibits av,�3Integrin-Induced Cell Migration and Invasion and Promotes Apoptosis of Breast Cancer Cells by Inducing Autophagy and Inactivating the PI3K/Akt/mTOR Pathway

(2014) Hao Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Osteopontin Is a Strong Predictor of Incipient Diabetic Nephropathy, Cardiovascular Disease, and All-Cause Mortality in Patients With Type 1 Diabetes

(2014) Daniel Gordin et al.   DIABETES CARE

N-Terminal Rather Than Full-Length Osteopontin or Its C-Terminal Fragment Is Associated With Carotid-Plaque Inflammation in Hypertensive Patients

(2013) T. Wolak et al.   AMERICAN JOURNAL OF HYPERTENSION

Osteopontin-mediated myocardial fibrosis in heart failure: a role for lysyl oxidase?

(2013) Begoña López et al.   CARDIOVASCULAR RESEARCH

Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis

(2013) Oriol Morales-Ibanez et al.   HEPATOLOGY

Osteopontin signaling upregulates cyclooxygenase-2 expression in tumor-associated macrophages leading to enhanced angiogenesis and melanoma growth via α9β1 integrin

(2013) S Kale et al.   ONCOGENE

Osteopontin, inflammation and myogenesis: influencing regeneration, fibrosis and size of skeletal muscle

(2013) Charles N. Pagel et al.   Journal of Cell Communication and Signaling

Andrographolide Inhibits Osteopontin Expression and Breast Tumor Growth Through Down Regulation of PI3 Kinase/Akt Signaling Pathway

(2012) S. Kumar et al.   CURRENT MOLECULAR MEDICINE

Linking complement and anti-dsDNA antibodies in the pathogenesis of systemic lupus erythematosus

(2012) Brendan M. Giles et al.   IMMUNOLOGIC RESEARCH

Thrombin-cleaved Fragments of Osteopontin Are Overexpressed in Malignant Glial Tumors and Provide a Molecular Niche with Survival Advantage

(2012) Yasuto Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Liver X Receptor Inhibits Osteopontin and Ameliorates Diabetic Nephropathy

(2012) H. Tachibana et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Basic and Translational Concepts of Immune-Mediated Glomerular Diseases

(2012) W. G. Couser   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Urinary OPN excretion in children with glomerular proteinuria

(2011) A Wasilewska et al.   Advances in Medical Sciences

Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin αVβ3 engagement and PI3K/pAkt/NFκB signaling

(2011) Raquel Urtasun et al.   HEPATOLOGY

Osteopontin-c Splicing Isoform Contributes to Ovarian Cancer Progression

(2011) T. M. Tilli et al.   MOLECULAR CANCER RESEARCH

Autoantibodies in systemic lupus erythematosus

(2011) Stephen D. Marks et al.   PEDIATRIC NEPHROLOGY

Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus

(2010) Xiaoxiang Yan et al.   Cardiovascular Diabetology

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis

(2010) Wing-Kin Syn et al.   HEPATOLOGY

Functional Heterogeneity of Osteopontin Isoforms in Non-small Cell Lung Cancer

(2010) Chandra M.V. Goparaju et al.   Journal of Thoracic Oncology

Critical role for osteopontin in diabetic nephropathy

(2010) Susanne B. Nicholas et al.   KIDNEY INTERNATIONAL

Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with  9 1 and  4 1 integrins

(2009) J. Grassinger et al.   BLOOD

Activation of JAK2/STAT3 signaling by osteopontin promotes tumor growth in human breast cancer cells

(2009) R. Behera et al.   CARCINOGENESIS

Cyclooxygenase-2 Inhibitors Down-regulate Osteopontin and Nr4a2—New Therapeutic Targets for Colorectal Cancers

(2009) Rachid Zagani et al.   GASTROENTEROLOGY

Polymeric Osteopontin Employs Integrin α9β1 as a Receptor and Attracts Neutrophils by Presenting ade NovoBinding Site

(2009) Norihisa Nishimichi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteopontin increases migration and MMP-9 up-regulation via αvβ3 integrin, FAK, ERK, and NF-κB-dependent pathway in human chondrosarcoma cells

(2009) Ying-Ju Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Osteopontin silencing by small interfering RNA induces apoptosis and suppresses invasion in human renal carcinoma Caki-1 cells

(2009) Aimin Zhang et al.   MEDICAL ONCOLOGY

Human Idiopathic Membranous Nephropathy — A Mystery Solved?

(2009) Richard J. Glassock   NEW ENGLAND JOURNAL OF MEDICINE

The Role of Osteopontin in the Development of Albuminuria

(2008) J. Lorenzen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Osteopontin regulates development and function of invariant natural killer T cells

(2008) H. Diao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA