Linking complement and anti-dsDNA antibodies in the pathogenesis of systemic lupus erythematosus

Low-Dose Targeted Complement Inhibition Protects against Renal Disease and Other Manifestations of Autoimmune Disease in MRL/lpr Mice

(2014) C. Atkinson et al.   JOURNAL OF IMMUNOLOGY

Increased IgG on cell-derived plasma microparticles in systemic lupus erythematosus is associated with autoantibodies and complement activation

(2012) Christoffer T. Nielsen et al.   ARTHRITIS AND RHEUMATISM

Factor H-related Protein 4 Activates Complement by Serving as a Platform for the Assembly of Alternative Pathway C3 Convertase via Its Interaction with C3b Protein

(2012) Mario Hebecker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice

(2011) Hideharu Sekine et al.   ARTHRITIS AND RHEUMATISM

Autoantibodies to intracellular antigens: Generation and pathogenetic role

(2011) Vito Racanelli et al.   AUTOIMMUNITY REVIEWS

Genetic CD21 deficiency is associated with hypogammaglobulinemia

(2011) Jens Thiel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

(2011) Irene Puga et al.   NATURE IMMUNOLOGY

Antibodies Elicited in Response to EBNA-1 May Cross-React with dsDNA

(2011) Pragya Yadav et al.   PLoS One

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Association of Genetic Variants in Complement Factor H and Factor H-Related Genes with Systemic Lupus Erythematosus Susceptibility

(2011) Jian Zhao et al.   PLoS Genetics

Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players

(2010) Kristin Kruse et al.   APOPTOSIS

Complement alternative pathway acts as a positive feedback amplification of neutrophil activation

(2010) L. Camous et al.   BLOOD

IgG human monoclonal anti-DNA autoantibodies from patients with systemic lupus erythematosus

(2010) T. H. WINKLER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)

(2010) Lars G. Fritsche et al.   HUMAN MOLECULAR GENETICS

Latent Membrane Protein 1, the EBV-Encoded Oncogenic Mimic of CD40, Accelerates Autoimmunity in B6.Sle1 Mice

(2010) A. L. Peters et al.   JOURNAL OF IMMUNOLOGY

Innate and Adaptive Receptors Interact to Balance Humoral Immunity

(2010) Thomas F. Tedder   JOURNAL OF IMMUNOLOGY

Activation of Macrophages by P2X7-Induced Microvesicles from Myeloid Cells Is Mediated by Phospholipids and Is Partially Dependent on TLR4

(2010) L. M. Thomas et al.   JOURNAL OF IMMUNOLOGY

Moving towards a cure: blocking pathogenic antibodies in systemic lupus erythematosus

(2010) B. Diamond et al.   JOURNAL OF INTERNAL MEDICINE

Complement Factor H Deficiency Accelerates Development of Lupus Nephritis

(2010) L. Bao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry

(2009) X. Kim-Howard et al.   ANNALS OF THE RHEUMATIC DISEASES

Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation

(2009) S. Heinen et al.   BLOOD

Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing

(2009) K B Douglas et al.   GENES AND IMMUNITY

The role of microparticles in the pathogenesis of rheumatic diseases

(2009) Christian Beyer et al.   Nature Reviews Rheumatology

Incidence and risk factors of infection in a single cohort of 110 adults with systemic lupus erythematosus

(2009) Su Jin Jeong et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

Association of three systemic lupus erythematosus susceptibility factors, PD-1.3A, C4AQ0, and low levels of mannan-binding lectin, with autoimmune manifestations in icelandic multicase systemic lupus erythematosus families

(2008) Helga Kristjansdottir et al.   ARTHRITIS AND RHEUMATISM

A Possible Link between Infection with Burkholderia Bacteria and Systemic Lupus Erythematosus Based on Epitope Mimicry

(2008) Wei Zhang et al.   Clinical & Developmental Immunology

Arginines in the CDR of anti-dsDNA autoantibodies facilitate cell internalizationviaelectrostatic interactions

(2008) Ying-Chyi Song et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

(2008) Swapan K Nath et al.   NATURE GENETICS

Systemic Lupus Erythematosus

(2008) Anisur Rahman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Naturally occurring auto-antibodies in homeostasis and disease

(2008) Hans U. Lutz et al.   TRENDS IN IMMUNOLOGY

Nature and functions of autoantibodies

(2008) Keith Elkon et al.   Nature clinical practice. Rheumatology