Triple Tumor Microenvironment‐Responsive Ferroptosis Pathways Induced by Manganese‐Based Imageable Nanoenzymes for Enhanced Breast Cancer Theranostics

Multienzyme-like Reactivity Cooperatively Impairs Glutathione Peroxidase 4 and Ferroptosis Suppressor Protein 1 Pathways in Triple-Negative Breast Cancer for Sensitized Ferroptosis Therapy

(2022) Ke Li et al.   ACS Nano

A “Closed‐Loop” Therapeutic Strategy Based on Mutually Reinforced Ferroptosis and Immunotherapy

(2022) Yaqian Du et al.   ADVANCED FUNCTIONAL MATERIALS

Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy

(2022) Lisi Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Metabolic Reprogramming Amino Acid Polymer as an Immunosurveillance Activator and Leukemia Targeting Drug Carrier for T‐Cell Acute Lymphoblastic Leukemia

(2022) Changzheng Li et al.   Advanced Science

Facile and One-step Direct Synthesis of Poly(valine) as a Robust Drug Nanocarrier for Enhanced Breast Cancer Therapy

(2022) Ya-Bin Meng et al.   CHINESE JOURNAL OF POLYMER SCIENCE

Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy

(2022) Hao Tian et al.   Nano Today

GSH‐Responsive Metal–Organic Framework for Intratumoral Release of NO and IDO Inhibitor to Enhance Antitumor Immunotherapy

(2022) Lihua Du et al.   Small

Effects of Polymer Molecular Weight on In Vitro and In Vivo Performance of Nanoparticle Drug Carriers for Lymphoma Therapy

(2022) Xinru You et al.   CHINESE CHEMICAL LETTERS

Bioactive spermidine nanoparticles for effective cardiovascular recovery and diabetic therapy

(2022) Tianqi Nie et al.   CHEMICAL ENGINEERING JOURNAL

A polyphenol-modified chitosan hybrid hydrogel with enhanced antimicrobial and antioxidant activities for rapid healing of diabetic wounds

(2022) Zejun Xu et al.   Nano Research

Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling

(2021) Hongxia Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Control by Heat Stress Determining Cell Fate to Ferroptosis for Effective Cancer Therapy

(2021) Shaowei Xie et al.   ACS Nano

Transformable Nanosensitizer with Tumor Microenvironment‐Activated Sonodynamic Process and Calcium Release for Enhanced Cancer Immunotherapy

(2021) Xuan Tan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Manganese salts function as potent adjuvants

(2021) Rui Zhang et al.   Cellular & Molecular Immunology

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Double‐Lock Nanomedicines Enable Tumor‐Microenvironment‐Responsive Selective Antitumor Therapy

(2021) Fang Liu et al.   ADVANCED FUNCTIONAL MATERIALS

Acidity‐Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer

(2021) Rundi Song et al.   ADVANCED MATERIALS

Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy

(2021) Jie Yang et al.   JOURNAL OF CONTROLLED RELEASE

The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

(2021) Chengxian Xu et al.   Cell Reports

Ferroptosis‐Enhanced Cancer Immunity by a Ferrocene‐Appended Iridium(III) Diphosphine Complex

(2021) Wen‐Jin Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ferroptosis in Cancer Cell Biology

(2020) Christina M. Bebber et al.   Cancers

Manganese-Based Nanoactivator Optimizes Cancer Immunotherapy via Enhancing Innate Immunity

(2020) Lin Hou et al.   ACS Nano

GSH and H 2 O 2 Co‐Activatable Mitochondria‐Targeted Photodynamic Therapy under Normoxia and Hypoxia

(2020) Jian Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis

(2020) Xuexian Fang et al.   CIRCULATION RESEARCH

Cleavable bimetallic-organic polymers for ROS mediated cascaded cancer therapy under the guidance of MRI through tumor hypoxia relief strategy

(2020) Haozhe He et al.   Science China-Chemistry

Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy

(2020) Haozhe He et al.   Small

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

(2020) Mengze Lv et al.   CELL RESEARCH

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

In situ activation of STING pathway with polymeric SN38 for cancer chemoimmunotherapy

(2020) Jiayu Zhao et al.   BIOMATERIALS

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

Metastasis and immune evasion from extracellular cGAMP hydrolysis

(2020) Jun Li et al.   Cancer Discovery

ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation

(2020) Mengjie Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumors and Their Microenvironment Dual‐Targeting Chemotherapy with Local Immune Adjuvant Therapy for Effective Antitumor Immunity against Breast Cancer

(2019) Caifeng Deng et al.   Advanced Science

The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11

(2019) Tong Liu et al.   CANCER RESEARCH

Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy

(2019) Anping Li et al.   Journal of Hematology & Oncology

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer

(2019) Constantia Pantelidou et al.   Cancer Discovery

Interferon-γ induces cancer cell ferroptosis

(2019) Laurence Zitvogel et al.   CELL RESEARCH

Multifunctional Nanoregulator Reshapes Immune Microenvironment and Enhances Immune Memory for Tumor Immunotherapy

(2019) Meng Yu et al.   Advanced Science

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

Manganese‐Based Functional Nanoplatforms: Nanosynthetic Construction, Physiochemical Property, and Theranostic Applicability

(2019) Xiaoqin Qian et al.   ADVANCED FUNCTIONAL MATERIALS

Recent Progress in Ferroptosis Inducers for Cancer Therapy

(2019) Chen Liang et al.   ADVANCED MATERIALS

Metal–Phenolic Network-Based Nanocomplexes that Evoke Ferroptosis by Apoptosis: Promoted Nuclear Drug Influx and Reversed Drug Resistance of Cancer

(2019) Yuxin Guo et al.   CHEMISTRY OF MATERIALS

Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy

(2019) Xuan Meng et al.   NANO LETTERS

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

All-in-One Theranostic Nanoagent with Enhanced Reactive Oxygen Species Generation and Modulating Tumor Microenvironment Ability for Effective Tumor Eradication

(2018) Yang Liu et al.   ACS Nano

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance

(2018) Xiang Ling et al.   NANO LETTERS

Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs

(2018) Julie M. Diamond et al.   Cancer Immunology Research

Covalent Organic Polymers Based on Fluorinated Porphyrin as Oxygen Nanoshuttles for Tumor Hypoxia Relief and Enhanced Photodynamic Therapy

(2018) Danlei Tao et al.   ADVANCED FUNCTIONAL MATERIALS

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Near-Infrared Polymeric Nanoparticles with High Content of Cyanine for Bimodal Imaging and Photothermal Therapy

(2016) Wenhai Lin et al.   ACS Applied Materials & Interfaces

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL