Role of LGMN in tumor development and its progression and connection with the tumor microenvironment

Oncogenic Role of Exosomal Circular and Long Noncoding RNAs in Gastrointestinal Cancers

(2022) Ba Da Yun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Combined Legumain- and Integrin- Targeted Nanobubbles for Molecular Ultrasound Imaging of Breast Cancer

(2022) Xue Mi et al.   Nanomedicine-Nanotechnology Biology and Medicine

Development of a Promising 18F-Radiotracer for PET Imaging Legumain Activity In Vivo

(2022) Chunmei Lu et al.   Pharmaceuticals

Targeting the adrenomedullin-2 receptor for the discovery and development of novel anti-cancer agents

(2022) Ameera B. A. Jailani et al.   Expert Opinion on Drug Discovery

Review of the Standard and Advanced Screening, Staging Systems and Treatment Modalities for Cervical Cancer

(2022) Siaw Shi Boon et al.   Cancers

Distinct patterns of responses in endothelial cells and smooth muscle cells following vascular injury

(2022) Xili Ding et al.   JCI Insight

Metabolic reprogramming in the immunosuppression of tumor-associated macrophages

(2022) Ying Wang et al.   CHINESE MEDICAL JOURNAL

Metformin regulates autophagy via LGMN to inhibit choriocarcinoma

(2022) Weiyan Tu et al.   GENE

Construction of a 980 nm laser-activated Pt(II) metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization

(2022) Yuling Xu et al.   Science China-Chemistry

Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

(2021) Ke Xu et al.   SCIENCE

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The Mechanism of Asparagine Endopeptidase in the Progression of Malignant Tumors: A Review

(2021) Wenrui Zhang et al.   Cells

AI-enhanced simultaneous multiparametric 18F-FDG PET/MRI for accurate breast cancer diagnosis

(2021) V. Romeo et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A turn on fluorescent assay for γ-glutamyltransferase activity and its application in biological imaging

(2021) Jian Gao et al.   TALANTA

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

The exosomal integrin α5β1/AEP complex derived from epithelial ovarian cancer cells promotes peritoneal metastasis through regulating mesothelial cell proliferation and migration

(2020) Xiaoduan Li et al.   CELLULAR ONCOLOGY

Synthesis and Evaluation of F Labeled Crizotinib Derivative [F]FPC as a Novel PET Probe for Imaging c-MET-positive NSCLC Tumor

(2020) Qingyu Lin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular Ultrasound Imaging

(2020) Gurbet Köse et al.   Nanomaterials

An Overview on Targeting Legumain for Inhibiting Cancers.

(2020) Bandi Deepa Reddy et al.   CURRENT PHARMACEUTICAL DESIGN

Macrophage-Derived Legumain Promotes Pulmonary Hypertension by Activating the MMP (Matrix Metalloproteinase)-2/TGF (Transforming Growth Factor)-β1 Signaling

(2019) Peiyuan Bai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Asparaginyl endopeptidase induces endothelial permeability and tumor metastasis via downregulating zonula occludens protein ZO-1

(2019) Lichun Kang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Recent advances in the development of legumain-selective chemical probes and peptide prodrugs

(2019) Marcin Poreba   BIOLOGICAL CHEMISTRY

A protease‐responsive fluorescent probe for sensitive imaging of legumain activity in living tumor cells

(2019) Xi Li et al.   Chemical Biology & Drug Design

Legumain Promotes Atherosclerotic Vascular Remodeling

(2019) Nana Ozawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Asparagine Endopeptidase in Mediating Wild-Type p53 Inactivation of Glioblastoma

(2019) Yingying Lin et al.   JNCI-Journal of the National Cancer Institute

Emerging roles of ECM remodeling processes in cancer

(2019) Vishnu Mohan et al.   SEMINARS IN CANCER BIOLOGY

Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation

(2019) Long Shen et al.   CANCER LETTERS

Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis Ex Vivo

(2019) Sunil Mathur et al.   International Journal of Peptide Research and Therapeutics

Legumain-Specific Near-Infrared Fluorescence “Turn On” for Tumor-Targeted Imaging

(2018) Yue Zhao et al.   ANALYTICAL CHEMISTRY

Asparaginyl endopeptidase enhances pancreatic ductal adenocarcinoma cell invasion in an exosome-dependent manner and correlates with poor prognosis

(2018) Qiang Yan et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

New insights into long noncoding RNAs and their roles in glioma

(2018) Zixuan Peng et al.   Molecular Cancer

Multidimensional communication in the microenvirons of glioblastoma

(2018) Marike L. Broekman et al.   Nature Reviews Neurology

Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ

(2018) Michael S. Toss et al.   MODERN PATHOLOGY

Extracellular Vesicles Released by Glioblastoma Cells Stimulate Normal Astrocytes to Acquire a Tumor-Supportive Phenotype Via p53 and MYC Signaling Pathways

(2018) S. Hallal et al.   MOLECULAR NEUROBIOLOGY

Precise nanomedicine for intelligent therapy of cancer

(2018) Huabing Chen et al.   Science China-Chemistry

Suppression of Asparaginyl Endopeptidase Inhibits Polyomavirus Middle T Antigen-Induced Tumor Formation and Metastasis

(2017) Cheng Xu et al.   ONCOLOGY RESEARCH

Phosphatidylinositol 3-kinase regulatory subunit 1 and phosphatase and tensin homolog as therapeutic targets in breast cancer

(2017) Ebubekir Dirican et al.   TUMOR BIOLOGY

Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression

(2017) Chongbiao Huang et al.   Nature Communications

Structure and function of legumain in health and disease

(2016) Elfriede Dall et al.   BIOCHIMIE

Asparaginyl endopeptidase promotes proliferation and invasiveness of prostate cancer cells via PI3K/AKT signaling pathway

(2016) Wenjing Zhu et al.   GENE

Knockdown of Legumain Suppresses Cervical Cancer Cell Migration and Invasion

(2016) Fei Meng et al.   ONCOLOGY RESEARCH

Asparaginyl endopeptidase promotes the invasion and metastasis of gastric cancer through modulating epithelial-to-mesenchymal transition

(2016) Yuehong Cui et al.   Oncotarget

M2 tumour-associated macrophages contribute to tumour progression via legumain remodelling the extracellular matrix in diffuse large B cell lymphoma

(2016) Long Shen et al.   Scientific Reports

Magnetic Graphene Nanosheet-Based Microfluidic Device for Homogeneous Real-Time Electronic Monitoring of Pyrophosphatase Activity Using Enzymatic Hydrolysate-Induced Release of Copper Ion

(2015) Youxiu Lin et al.   ANALYTICAL CHEMISTRY

EMT Blockage Strategies: Targeting Akt Dependent Mechanisms for Breast Cancer Metastatic Behaviour Modulation

(2015) D. Rafael et al.   CURRENT GENE THERAPY

High expression of the cysteine proteinase legumain in colorectal cancer – Implications for therapeutic targeting

(2015) Mads H. Haugen et al.   EUROPEAN JOURNAL OF CANCER

Phosphatidylinositol Phosphate 5-Kinase Iγ and Phosphoinositide 3-Kinase/Akt Signaling Couple to Promote Oncogenic Growth

(2015) Narendra Thapa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Alpha2beta1 integrin in cancer development and chemoresistance

(2015) Dalila Naci et al.   SEMINARS IN CANCER BIOLOGY

Nanovesicles engineered from ES cells for enhanced cell proliferation

(2014) Dayeong Jeong et al.   BIOMATERIALS

Accumulation of Memory Precursor CD8 T Cells in Regressing Tumors following Combination Therapy with Vaccine and Anti-PD-1 Antibody

(2014) L. Karyampudi et al.   CANCER RESEARCH

Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage

(2014) Lixia Zhao et al.   CELL RESEARCH

Activating Mutations in PTPN3 Promote Cholangiocarcinoma Cell Proliferation and Migration and Are Associated With Tumor Recurrence in Patients

(2014) Qiang Gao et al.   GASTROENTEROLOGY

Enhancement of DNA Vaccine Potency Against Legumain

(2014) Michal Smahel et al.   JOURNAL OF IMMUNOTHERAPY

Functional Role of Asparaginyl Endopeptidase Ubiquitination by TRAF6 in Tumor Invasion and Metastasis

(2014) Yingying Lin et al.   JNCI-Journal of the National Cancer Institute

Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment

(2014) Ze Liu et al.   Nature Communications

Specific Inhibition of the VEGFR-3 Tyrosine Kinase by SAR131675 Reduces Peripheral and Tumor Associated Immunosuppressive Myeloid Cells

(2014) Nicolas Espagnolle et al.   Cancers

Peptide-based MRI contrast agent and near-infrared fluorescent probe for intratumoral legumain detection

(2013) Yu-Jen Chen et al.   BIOMATERIALS

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Expression of Lewis y antigen and integrin αv, β3 in ovarian cancer and their relationship with chemotherapeutic drug resistance

(2013) Jian Gao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Effects of legumain as a potential prognostic factor on gastric cancers

(2013) Na Li et al.   MEDICAL ONCOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Nuclear Legumain Activity in Colorectal Cancer

(2013) Mads H. Haugen et al.   PLoS One

Hydrazinocurcumin Encapsuled Nanoparticles “Re-Educate” Tumor-Associated Macrophages and Exhibit Anti-Tumor Effects on Breast Cancer Following STAT3 Suppression

(2013) Xiwen Zhang et al.   PLoS One

Alginic Acid-Coated Chitosan Nanoparticles Loaded with Legumain DNA Vaccine: Effect against Breast Cancer in Mice

(2013) Ze Liu et al.   PLoS One

Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation

(2013) E. Dall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the TGF-β/BMP-7/Smad pathways in renal diseases

(2012) Xiao-Ming Meng et al.   CLINICAL SCIENCE

Legumain: A biomarker for diagnosis and prognosis of human ovarian cancer

(2012) Lina Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Adrenomedullin expression in epithelial ovarian cancers and promotes HO8910 cell migration associated with upregulating integrin α5β1 and phosphorylating FAK and paxillin

(2012) Boya Deng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Functional Imaging of Legumain in Cancer Using a New Quenched Activity-Based Probe

(2012) Laura E. Edgington et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

SAR131675, a Potent and Selective VEGFR-3-TK Inhibitor with Antilymphangiogenic, Antitumoral, and Antimetastatic Activities

(2012) A. Alam et al.   MOLECULAR CANCER THERAPEUTICS

Association of legumain expression pattern with prostate cancer invasiveness and aggressiveness

(2012) Yoshio Ohno et al.   WORLD JOURNAL OF UROLOGY

Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo

(2011) Andrea Conidi et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Development of Near-Infrared Fluorophore (NIRF)-Labeled Activity-Based Probes forin VivoImaging of Legumain

(2009) Jiyoun Lee et al.   ACS Chemical Biology

Response of contrast agents to ultrasound

(2008) Vassilis Sboros   ADVANCED DRUG DELIVERY REVIEWS