Article
Oncology
Shitong Zhang, Xianhu Fu
Summary: The study explores the expression and mechanism of PCDH7 in cervical cancer and evaluates its clinical prognostic significance. PCDH7 is downregulated in cervical cancer tissues and cell lines, and its low expression is associated with a low survival rate. PCDH7 may be used as an independent prognostic factor for cervical cancer, impacting cancer cell proliferation, migration, and invasion.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Cell Biology
Dan Lei, Wen-Ting Yang, Peng-Sheng Zheng
Summary: HOXB4 suppresses cervical cancer cell proliferation and tumorigenesis by inhibiting the activity of the Wnt/beta-catenin signaling pathway.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Na Qu, Yiming Meng, Jingbo Zhai, Noreen Griffin, Yuanye Shan, Yuhua Gao, Fengping Shan
Summary: This study found that methionine enkephalin (menk) inhibited the migration and invasion of cervical cancer cells by affecting epithelial-mesenchymal transition (EMT) related indicators. Additionally, menk was able to activate CD11b+ NCR1+ NK cells in the tumor microenvironment. These findings provide a theoretical foundation for the further clinical treatment of menk.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Haichen Long, Yangyang Li, Huijuan Wang, Bingxuan Guo, Shuyan Song, Xiangyi Zhe, Hongtao Li, Dongmei Li, Renfu Shao, Zemin Pan
Summary: The expression of C/EBP beta is decreased in cervical cancer tissues, while overexpression of the C/EBP beta gene in cervical cancer cells can inhibit proliferation, invasion, and migration.
Article
Oncology
Rui Yang, Mingjun Ma, Sihui Yu, Xi Li, Jiawen Zhang, Sufang Wu
Summary: PAMR1 is identified as an invasion-related regulator in cervical cancer, with higher expression associated with better prognosis. Knockdown of PAMR1 facilitates the proliferation, migration, and invasion of cervical cancer cells, and it also inhibits MYC target and mTORC1 signaling pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Andrea R. Marcadis, Elizabeth Kao, Qi Wang, Chun-Hao Chen, Laxmi Gusain, Ann Powers, Richard L. Bakst, Sylvie Deborde, Richard J. Wong
Summary: The invasion of nerves by cancer cells, or perineural invasion (PNI), is influenced by the nerve microenvironment and is associated with negative clinical outcomes. However, the specific characteristics of cancer cells that enable PNI have not been well defined. Through serial passaging of pancreatic cancer cells in a murine sciatic nerve model of PNI, we generated cell lines enriched for a rapid neuroinvasive phenotype. These leading neuroinvasive cells exhibited upregulation of proteins involving the plasma membrane, cell leading edge, and cell movement. They also underwent phenotypic changes from a mesenchymal to an amoeboid phenotype, and acquired increased migration ability and affinity for dorsal root ganglia. Inhibition of ROCK reversed these changes and reduced PNI in a murine sciatic nerve model. This study highlights the plasticity of cancer migration mode in facilitating rapid nerve invasion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biotechnology & Applied Microbiology
Xuehe Wang, Huaqin Sun, Simin Zhu
Summary: The study demonstrated that an aberrant upregulation of PTAR in cervical cancer tissues and cell lines promotes proliferation, migration, and invasion of HeLa cells, while inhibiting apoptosis and downregulating miR-101 expression through direct binding. These findings suggest that PTAR plays a crucial role and may serve as a promising target for cervical cancer diagnosis and therapy.
Article
Oncology
Yingchun Liu, Li Li, Zhe Yang, Dan Wen, Zhenyu Hu
Summary: Circular RNA circACAP2 inhibits ferroptosis in cervical cancer through the miR-193a-5p/GPX4 pathway.
JOURNAL OF ONCOLOGY
(2022)
Article
Cell Biology
Longchang Bai, Yingkang Ma, Xue Wang, Qiongni Feng, Zhining Zhang, Sijie Wang, Huijie Zhang, Xinyu Lu, Yonghui Xu, Erhu Zhao, Hongjuan Cui
Summary: Polydatin, derived from Polygonum cuspidatum roots, exhibits anti-tumor activity against human cervical cancer by regulating cell cycle-related proteins and epithelial-mesenchymal transition markers, while suppressing the expression of the proto-oncogene c-Myc. Overexpression of c-Myc rescues the inhibitory effect of Polydatin on cell proliferation and metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Jianan Zhang, Qi Shen, Lu Xia, Xueqiong Zhu, Xuejie Zhu
Summary: This study investigated the role of DYNLT3 protein in cervical cancer and its molecular mechanisms. The results showed that DYNLT3 inhibited cell proliferation, migration, and invasion in cervical cancer, and promoted apoptosis. It was also found that DYNLT3 suppressed the expression of Wnt signaling pathway and EMT-related proteins. Furthermore, upregulation of DYNLT3 expression inhibited tumor growth and metastasis in vivo.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xun Zhang, Yujue Wang, Xue Wang, Bingyu Zou, Jie Mei, Xue Peng, Zhao Wu
Summary: Our study revealed that miR-10a-5p in CAF-derived EVs promotes angiogenesis and tumorigenesis of cervical squamous cell carcinoma cells by inhibiting TBX5 and activating the Hedgehog signaling pathway. These findings suggest a novel therapeutic strategy targeting miR-10a-5p against CSCC.
CANCER GENE THERAPY
(2021)
Article
Obstetrics & Gynecology
Yu-feng Gong, Yu Zhang, Li-yang Li, Wen Han, Yang Liu
Summary: miR-599 is downregulated in cervical cancer and is associated with lymph node metastasis and FIGO stage. Overexpression of miR-599 suppresses cell proliferation, migration, and invasion in cervical cancer cells, indicating its tumor suppressor role.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2022)
Article
Environmental Sciences
Chung-Yuan Lee, Yung-Chuan Ho, Chiao-Wen Lin, Min-Chieh Hsin, Po-Hui Wang, Ya-Cheng Tang, Shun-Fa Yang, Yi-Hsuan Hsiao
Summary: The synthetic curcumin analog, EF-24, has been shown to have enhanced bioavailability and stronger anti-inflammatory and anti-cancer activity compared to curcumin. This study investigated the effects of EF-24 on TPA-induced cellular migration of cervical cancer and found that EF-24 significantly reduced cellular migration and invasion. Further analysis revealed that EF-24 modulated MMP-9 expression by inhibiting the phosphorylation of the p38 signaling pathway. These findings suggest that EF-24 may have potential as a chemopreventive agent for cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiumei Feng, Qingchun Zhang, Qianjin Xu, Meiqin Shao
Summary: This study investigated the effects of miR-202 and GLI2 on cell metastasis and epithelial-mesenchymal transition (EMT) in cervical cancer (CC). The results showed that overexpression of miR-202 inhibited CC cell metastasis and EMT by regulating GLI2 mRNA expression. This finding provides new insights for the clinical treatment of CC.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Cell Biology
Xin Shen, Lingxia Li, Yuanyuan He, Xiaohui Lv, Jiajia Ma
Summary: Raddeanin A inhibits proliferation, invasion, and migration while promoting apoptosis of cervical cancer cells through the miR-224-3p/Slit2/Robo1 signaling pathway.
