LncRNA MHRT Prevents Angiotensin II-Induced Myocardial Oxidative Stress and NLRP3 Inflammasome via Nrf2 Activation

Targeting Nrf2 in ischemia-reperfusion alleviation: From signaling networks to therapeutic targeting

(2022) Mehrdokht Sadrkhanloo et al.   LIFE SCIENCES

Role of long non-coding RNAs on the regulation of Nrf2 in chronic diseases

(2021) Ravichandran Jayasuriya et al.   LIFE SCIENCES

Sulforaphane prevents angiotensin II‐induced cardiomyopathy by activation of Nrf2 through epigenetic modification

(2021) Xuling Su et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lp-PLA2 inhibition prevents Ang II-induced cardiac inflammation and fibrosis by blocking macrophage NLRP3 inflammasome activation

(2021) Si-lin Lv et al.   ACTA PHARMACOLOGICA SINICA

LncRNA MHRT Promotes Cardiac Fibrosis via miR-3185 Pathway Following Myocardial Infarction

(2021) Mingjian Lang et al.   International Heart Journal

Ginsenoside Rg3 attenuates angiotensin II-induced myocardial hypertrophy through repressing NLRP3 inflammasome and oxidative stress via modulating SIRT1/NF-κB pathway

(2021) Bei Ren et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

LncRNA-Mhrt regulates cardiac hypertrophy by modulating the miR-145a-5p/KLF4/myocardin axis

(2020) Yao Xu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Resveratrol protects against CIH-induced myocardial injury by targeting Nrf2 and blocking NLRP3 inflammasome activation

(2020) Zhi-Min Sun et al.   LIFE SCIENCES

Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway

(2020) Zhihui Chen et al.   BIOCHEMICAL PHARMACOLOGY

Nrf2 deficiency aggravates Angiotensin II-induced cardiac injury by increasing hypertrophy and enhancing IL-6/STAT3-dependent inflammation

(2019) Dandan Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGFβ1/Smad2/3 signaling axis

(2019) Rui-Rui Chen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Genomic data mining for functional annotation of human long noncoding RNAs

(2019) Brian L. Gudenas et al.   Journal of Zhejiang University-SCIENCE B

LncRNA PCFL promotes cardiac fibrosis via miR-378/GRB2 pathway following myocardial infarction

(2019) Fei Sun et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Differential Expression Profiles and Functional Prediction of Circular RNAs and Long Non-coding RNAs in the Hippocampus of Nrf2-Knockout Mice

(2019) Run-Jiao Zhang et al.   Frontiers in Molecular Neuroscience

The SGK1 inhibitor EMD638683, prevents Angiotensin II–induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation

(2018) Wenqiang Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The mechanism of myocardial hypertrophy regulated by the interaction between mhrt and myocardin

(2018) Ying Luo et al.   CELLULAR SIGNALLING

Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway

(2018) Xuling Su et al.   Oxidative Medicine and Cellular Longevity

Nrf2 Is a Key Regulator on Puerarin Preventing Cardiac Fibrosis and Upregulating Metabolic Enzymes UGT1A1 in Rats

(2018) Shao-Ai Cai et al.   Frontiers in Pharmacology

Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway

(2018) Ying Xin et al.   Redox Biology

Klotho protein inhibits H2O2-induced oxidative injury in endothelial Cells via regulation of PI3K/Akt/Nrf2/HO-1 Pathways.

(2018) wei cui et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The lncRNA H19/miR-675 axis regulates myocardial ischemic and reperfusion injury by targeting PPARα

(2018) Hong Luo et al.   MOLECULAR IMMUNOLOGY

Inhibition of JNK and activation of the AMPK-Nrf2 axis by corosolic acid suppress osteolysis and oxidative stress

(2018) Mingzheng Peng et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Role of NLRP3 Inflammasomes in Atherosclerosis

(2017) Tadayoshi Karasawa et al.   Journal of Atherosclerosis and Thrombosis

Obestatin attenuated doxorubicin-induced cardiomyopathy via enhancing long noncoding Mhrt RNA expression

(2016) Hong-qi Li et al.   BIOMEDICINE & PHARMACOTHERAPY

The Biological Basis for Cardiac Repair After Myocardial Infarction

(2016) Sumanth D. Prabhu et al.   CIRCULATION RESEARCH

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

(2016) Deepika Sharma et al.   JOURNAL OF CELL BIOLOGY

Involvement of endoplasmic reticulum stress in angiotensin II-induced NLRP3 inflammasome activation in human renal proximal tubular cells in vitro

(2015) Jing Wang et al.   ACTA PHARMACOLOGICA SINICA

Histone Methyltransferase SET1 Mediates Angiotensin II-Induced Endothelin-1 Transcription and Cardiac Hypertrophy in Mice

(2015) L. Yu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ROS signalling between endothelial cells and cardiac cells

(2014) M. Zhang et al.   CARDIOVASCULAR RESEARCH

Adiponectin Suppresses Angiotensin II-Induced Inflammation and Cardiac Fibrosis through Activation of Macrophage Autophagy

(2014) Guan-Ming Qi et al.   ENDOCRINOLOGY

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Naringenin confers protection against oxidative stress through upregulation of Nrf2 target genes in cardiomyoblast cells

(2014) Tharmarajan Ramprasath et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

A long noncoding RNA protects the heart from pathological hypertrophy

(2014) Pei Han et al.   NATURE

Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways

(2013) Sena Kim et al.   Innate Immunity

Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation

(2013) Yang Bai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Angiotensin II Receptor Blocker Attenuates Intrarenal Renin-Angiotensin-System and Podocyte Injury in Rats with Myocardial Infarction

(2013) Zhu-zhi Wen et al.   PLoS One

Angiotensin II, NADPH Oxidase, and Redox Signaling in the Vasculature

(2012) Aurelie Nguyen Dinh Cat et al.   ANTIOXIDANTS & REDOX SIGNALING

Angiotensin II-Induced Production of Mitochondrial Reactive Oxygen Species: Potential Mechanisms and Relevance for Cardiovascular Disease

(2012) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

Allicin Ameliorates Cardiac Hypertrophy and Fibrosis through Enhancing of Nrf2 Antioxidant Signaling Pathways

(2012) Xian-Hui Li et al.   CARDIOVASCULAR DRUGS AND THERAPY

Angiotensin II Plays a Critical Role in Alcohol-Induced Cardiac Nitrative Damage, Cell Death, Remodeling, and Cardiomyopathy in a Protein Kinase C/Nicotinamide Adenine Dinucleotide Phosphate Oxidase–Dependent Manner

(2012) Yi Tan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Up-regulation of p27kip1 contributes to Nrf2-mediated protection against angiotensin II-induced cardiac hypertrophy

(2011) Jinqing Li et al.   CARDIOVASCULAR RESEARCH

Angiotensin II induces inflammation leading to cardiac remodeling

(2011) Lixin Jia   Frontiers in Bioscience-Landmark

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

(2011) E. Mezzaroma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An essential role of Nrf2 in American ginseng-mediated anti-oxidative actions in cardiomyocytes

(2010) Jinqing Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Evolution and Functions of Long Noncoding RNAs

(2009) Chris P. Ponting et al.   CELL

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intracardiac renin–angiotensin system and myocardial repair/remodeling following infarction

(2009) Yao Sun   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

(2008) Xiaoqing He et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Metallothionein Suppresses Angiotensin II–Induced Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation, Nitrosative Stress, Apoptosis, and Pathological Remodeling in the Diabetic Heart

(2008) Guihua Zhou et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE