Salmonella effector SopF regulates PANoptosis of intestinal epithelial cells to aggravate systemic infection

Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation

(2022) Jian Zhang et al.   Science Immunology

Salmonella pSLT-encoded effector SpvB promotes RIPK3-dependent necroptosis in intestinal epithelial cells

(2022) Kedi Dong et al.   Cell Death Discovery

Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation

(2022) Aleksandra Levina et al.   Nature Communications

Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells

(2022) Nawar Naseer et al.   INFECTION AND IMMUNITY

Computational prediction and experimental validation of Salmonella Typhimurium SopE-mediated fine-tuning of autophagy in intestinal epithelial cells

(2022) Amanda Demeter et al.   Frontiers in Cellular and Infection Microbiology

Salmonella enterica Serovar Typhimurium Exploits Cycling through Epithelial Cells To Colonize Human and Murine Enteroids

(2021) Petra Geiser et al.   mBio

Salmonella spvC Gene Inhibits Pyroptosis and Intestinal Inflammation to Aggravate Systemic Infection in Mice

(2021) Lingli Zuo et al.   Frontiers in Microbiology

The Salmonella effector protein SopD targets Rab8 to positively and negatively modulate the inflammatory response

(2021) Huan Lian et al.   Nature Microbiology

Regulation of Caspase-8 Activity at the Crossroads of Pro-Inflammation and Anti-Inflammation

(2021) Jun-Hyuk Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice

(2021) Stefan A. Fattinger et al.   Mucosal Immunology

Salmonella Typhimurium and inflammation: a pathogen-centric affair

(2021) Jorge E. Galán   NATURE REVIEWS MICROBIOLOGY

Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers

(2021) Pilar Samperio Ventayol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy-competent mitochondrial translation elongation factor TUFM inhibits caspase-8-mediated apoptosis

(2021) Chang-Yong Choi et al.   CELL DEATH AND DIFFERENTIATION

Systematic reconstruction of an effector-gene network reveals determinants of Salmonella cellular and tissue tropism

(2021) Didi Chen et al.   Cell Host & Microbe

Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn’s disease by promoting intestinal inflammation

(2021) Gao Tan et al.   Cell Reports

Salmonella effector driven invasion of the gut epithelium: breaking in and setting the house on fire

(2021) Stefan A Fattinger et al.   CURRENT OPINION IN MICROBIOLOGY

Activation of apoptosis by Salmonella pathogenicity island-1 effectors through both intrinsic and extrinsic pathways in Salmonella-infected macrophages

(2020) Hsin-Hung Lin et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression

(2020) Annika Hausmann et al.   Mucosal Immunology

Caspase-8: The double-edged sword

(2020) Ranadip Mandal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Salmonella Interacts With Autophagy to Offense or Defense

(2020) Shu Wu et al.   Frontiers in Microbiology

A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade

(2020) Zhang-Hua Yang et al.   MOLECULAR CELL

SopA inactivation or reduced expression is selected in intracellular Salmonella and contributes to systemic Salmonella infection

(2020) Shuangshuang Ma et al.   RESEARCH IN MICROBIOLOGY

Epithelial inflammasomes in the defense against Salmonella gut infection

(2020) Stefan A Fattinger et al.   CURRENT OPINION IN MICROBIOLOGY

PANoptosis in microbial infection

(2020) David E Place et al.   CURRENT OPINION IN MICROBIOLOGY

Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions

(2019) Julia Y. Co et al.   Cell Reports

Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways

(2019) Joshua PM Newson et al.   MOLECULAR & CELLULAR PROTEOMICS

Salmonella Outer Protein B Suppresses Colitis Development via Protecting Cell From Necroptosis

(2019) Gui-Qiu Hu et al.   Frontiers in Cellular and Infection Microbiology

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy

(2019) Yue Xu et al.   CELL

SopF, a phosphoinositide binding effector, promotes the stability of the nascent Salmonella-containing vacuole

(2019) Nicole Lau et al.   PLoS Pathogens

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut

(2019) Erik Bakkeren et al.   NATURE

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Intestinal epithelial Caspase-8 signaling is essential to prevent necroptosis during Salmonella Typhimurium induced enteritis

(2018) Manuela Hefele et al.   Mucosal Immunology

Defining the role of the RSK isoforms in cancer

(2018) Thibault Houles et al.   SEMINARS IN CANCER BIOLOGY

ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages

(2018) Bettina L. Lee et al.   Scientific Reports

SopB activates the Akt-YAP pathway to promote Salmonella survival within B cells

(2018) Abraham García-Gil et al.   Virulence

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8

(2017) Isabella Rauch et al.   IMMUNITY

Identification of a NovelSalmonellaType III Effector by Quantitative Secretome Profiling

(2017) Sen Cheng et al.   MOLECULAR & CELLULAR PROTEOMICS

Cirtical role for Salmonella effector SopB in regulating inflammasome activation

(2017) Gui-Qiu Hu et al.   MOLECULAR IMMUNOLOGY

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

(2017) Nina Van Opdenbosch et al.   Cell Reports

Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion

(2015) Caroline Mauvezin et al.   Autophagy

Now you see me, now you don't: the interaction of Salmonella with innate immune receptors

(2015) A. Marijke Keestra-Gounder et al.   NATURE REVIEWS MICROBIOLOGY

Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa

(2014) Mikael E. Sellin et al.   Cell Host & Microbe

Getting Rid of the Bad Apple: Inflammasome-Induced Extrusion of Salmonella -Infected Enterocytes

(2014) Petr Broz   Cell Host & Microbe

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

(2012) Megan M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of NLRC4 is critical for inflammasome activation

(2012) Yan Qu et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dissemination of invasiveSalmonellavia bacterial-induced extrusion of mucosal epithelia

(2010) Leigh A. Knodler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA