Hexokinase dissociation from mitochondria promotes oligomerization of VDAC that facilitates NLRP3 inflammasome assembly and activation

Innate Sensors Trigger Regulated Cell Death to Combat Intracellular Infection

(2022) Kengo Nozaki et al.   Annual Review of Immunology

Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3

(2022) Inga V. Hochheiser et al.   NATURE

Hexokinase 1 cellular localization regulates the metabolic fate of glucose

(2022) Adam De Jesus et al.   MOLECULAR CELL

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

(2022) Hongxu Xian et al.   IMMUNITY

Mitochondrial DNA in NLRP3 inflammasome activation

(2022) Yanbing Qiu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network

(2022) Niklas A. Schmacke et al.   IMMUNITY

The Complex Dance of Organelles during Mitochondrial Division

(2021) Luis-Carlos Tábara et al.   TRENDS IN CELL BIOLOGY

Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters

(2021) Francesco Ciscato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of Mitochondrial Respiration by VDAC Is Enhanced by Membrane-Bound Inhibitors with Disordered Polyanionic C-Terminal Domains

(2021) Tatiana K. Rostovtseva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of the mitochondrial protein VDAC1 in inflammatory bowel disease: a potential therapeutic target

(2021) Ankit Verma et al.   MOLECULAR THERAPY

Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation

(2021) Ana Tapia-Abellán et al.   Science Advances

NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation

(2021) Liudmila Andreeva et al.   CELL

Inflammasome activation by Salmonella

(2021) Bryant Clare   CURRENT OPINION IN MICROBIOLOGY

Molecular mechanisms and consequences of mitochondrial permeability transition

(2021) Massimo Bonora et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

(2020) Jeonghan Kim et al.   SCIENCE

Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca 2+ ‐dependent death of cancer cells

(2020) Francesco Ciscato et al.   EMBO REPORTS

N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

(2020) Mausita Karmakar et al.   Nature Communications

Cyclophilin D: An Integrator of Mitochondrial Function

(2020) Georgios Amanakis et al.   Frontiers in Physiology

Differential role of the NLRP3 inflammasome in infection and tumorigenesis

(2019) Sarang Tartey et al.   IMMUNOLOGY

Innate immunity to intracellular LPS

(2019) Vijay A. K. Rathinam et al.   NATURE IMMUNOLOGY

Dissociation of mitochondrial HK-II elicits mitophagy and confers cardioprotection against ischemia

(2019) Valerie P. Tan et al.   Cell Death & Disease

DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1

(2019) Yi Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitors of the mitochondrial calcium uniporter for the treatment of disease

(2019) Joshua J. Woods et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The complexity of mitochondrial outer membrane permeability and VDAC regulation by associated proteins

(2018) Aleksandr Klepinin et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Cutting Edge: Mitochondrial Assembly of the NLRP3 Inflammasome Complex Is Initiated at Priming

(2018) Eric I. Elliott et al.   JOURNAL OF IMMUNOLOGY

MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice

(2018) Agampodi Promoda Perera et al.   Scientific Reports

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

(2018) Jueqi Chen et al.   NATURE

Mitochondrial DNA depletion by ethidium bromide decreases neuronal mitochondrial creatine kinase: Implications for striatal energy metabolism

(2017) Emily Booth Warren et al.   PLoS One

Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target

(2017) Amadou K. S. Camara et al.   Frontiers in Physiology

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

(2016) Andrea J. Wolf et al.   CELL

Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents AtherosclerosisNovelty and Significance

(2016) Gantsetseg Tumurkhuu et al.   CIRCULATION RESEARCH

K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

(2016) Christina J. Groß et al.   IMMUNITY

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction

(2016) Danya Ben-Hail et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation

(2016) Joachim Lauterwasser et al.   Scientific Reports

Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

(2015) Chul-Su Yang et al.   Nature Communications

Ca2+-mediated regulation of VDAC1 expression levels is associated with cell death induction

(2014) Shira Weisthal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

(2014) D J Roberts et al.   CELL DEATH AND DIFFERENTIATION

Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells

(2014) Silvia Alfonso-Loeches et al.   Frontiers in Cellular Neuroscience

The role of calcium in VDAC1 oligomerization and mitochondria-mediated apoptosis

(2013) Nurit Keinan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity

(2013) S. Park et al.   JOURNAL OF IMMUNOLOGY

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Mechanisms of disease: inflammasome activation and the development of type 2 diabetes

(2013) Ryan W. Grant et al.   Frontiers in Immunology

The Role of Lipids in VDAC Oligomerization

(2012) Viktoria Betaneli et al.   BIOPHYSICAL JOURNAL

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VDAC isoforms in mammals

(2011) Angela Messina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Subcellular Localization of Hexokinases I and II Directs the Metabolic Fate of Glucose

(2011) Scott John et al.   PLoS One

Staphylococcus aureus Evades Lysozyme-Based Peptidoglycan Digestion that Links Phagocytosis, Inflammasome Activation, and IL-1β Secretion

(2010) Takahiro Shimada et al.   Cell Host & Microbe

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

(2010) Irving C. Allen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oligomerization of the Mitochondrial Protein Voltage-Dependent Anion Channel Is Coupled to the Induction of Apoptosis

(2010) N. Keinan et al.   MOLECULAR AND CELLULAR BIOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins

(2009) S. Abu-Hamad et al.   JOURNAL OF CELL SCIENCE

Regulation of hexokinase binding to VDAC

(2008) John G. Pastorino et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Voltage-dependent Anion Channel 1-based Peptides Interact with Hexokinase to Prevent Its Anti-apoptotic Activity

(2008) Laetitia Arzoine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels

(2008) Federica Chiara et al.   PLoS One

Mapping the ruthenium red-binding site of the voltage-dependent anion channel-1

(2007) Adrian Israelson et al.   CELL CALCIUM